Functional expression of human 5-HT1A receptors and differential coupling to second messengers in CHO cells

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

1978 • 2,400 citations

Enzyme changes in neonatal skeletal muscle: effect of thyroid deficiency

1978 • 1,103 citations

[71] Use of eukaryotic expression technology in the functional analysis of cloned genes

1987 • 834 citations

Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PAT

1983 • 759 citations

Differential regulation of PI hydrolysis and adenylyl cyclase by muscarinic receptor subtypes

1988 • 669 citations

The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT1A receptor

1988 • 594 citations

Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: Radioligand binding studies with [3H]5-HT, [3H]8-OH-DPAT, (−)[125I]iodocyanopindolol, [3H]mesulergine and [3H]Ketanserin

1985 • 581 citations

Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes.

1982 • 573 citations

Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro.

1987 • 550 citations

An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins

1987 • 509 citations

Differential modulation of three separate K-conductances in hippocampal CA1 neurons by serotonin

1987 • 463 citations

Cloning, functional expression, and mRNA tissue distribution of the rat 5-hydroxytryptamine1A receptor gene.

1990 • 444 citations

Characterization of the 5-hydroxytryptamine1a receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig and rat hippocampal membranes.

1986 • 420 citations

An M2 Muscarinic Receptor Subtype Coupled to Both Adenylyl Cyclase and Phosphoinositide Turnover

1987 • 398 citations

Receptors linked to inhibition of adenylate cyclase: additional signaling mechanisms

1988 • 339 citations

Effector Coupling Mechanisms of the Cloned 5-HT1A Receptor

1989 • 273 citations

Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells.

1990 • 270 citations

Dopamine activation of the arachidonic acid cascade as a basis for D1D2 receptor synergism

1991 • 262 citations

Functionally distinct G proteins selectively couple different receptors to PI hydrolysis in the same cell

1989 • 259 citations

Receptor-mediated activation of phospholipase A2 and arachidonic acid release in signal transduction

1990 • 247 citations

Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor.

1991 • 225 citations

Lipoxygenase metabolites of arachidonic acid in neuronal transmembrane signalling

1990 • 200 citations

5-HT1A-receptors mediate stimulation of adenylate cyclase in rat hippocampus

1986 • 197 citations

Cloning, sequence analysis, and permanent expression of a human α2-adrenergic receptor in Chinese hamster ovary cells

1989 • 152 citations

Pharmacology of 5-hydroxytryptamine-1A receptors which inhibit cAMP production in hippocampal and cortical neurons in primary culture.

1988 • 150 citations

Identification of the subunits of GTP-binding proteins coupled to somatostatin receptors.

1991 • 144 citations

Piperazine derivatives including the putative anxiolytic drugs, buspirone and ipsapirone, are agonists at 5-HT1A receptors negatively coupled with adenylate cyclase in hippocampal neurons

1987 • 136 citations

Transfected D2 dopamine receptors mediate the potentiation of arachidonic acid release in Chinese hamster ovary cells.

1991 • 124 citations

Protein kinase C induces phosphorylation and desensitization of the human 5-HT1A receptor

1991 • 115 citations

A G Protein Mutant That Inhibits Thrombin and Purinergic Receptor Activation of Phospholipase A₂

1990 • 108 citations

Agonist/antagonist interactions with cloned human 5-HT1A receptors: variations in intrinsic activity studied in transfected HeLa cells

1992 • 104 citations

Two 5-HT receptors linked to adenylate cyclase in guinea pig hippocampus are discriminated by 5-carboxamidotryptamine and spiperone

1985 • 102 citations

Functional responses of cloned muscarinic receptors expressed in CHO-K1 cells.

1991 • 99 citations

Serotonin 5-HT1 receptors mediate inhibition of cyclic AMP production in neurons

1986 • 91 citations

Cell-specific signaling of the 5-HT1A receptor. Modulation by protein kinases C and A.

1991 • 89 citations

Differential activation of protein kinase C alpha is associated with arachidonate release in Madin-Darby canine kidney cells.

1990 • 85 citations

A transduction pathway associated with receptors coupled to the inhibitory guanine nucleotide binding protein Gi that amplifies ATP-mediated arachidonic acid release.

1991 • 84 citations

NAN-190: agonist and antagonist interactions with brain 5-HT1A receptors

1990 • 80 citations

Alpha 2-adrenergic receptor stimulation of phospholipase A2 and of adenylate cyclase in transfected Chinese hamster ovary cells is mediated by different mechanisms.

1991 • 80 citations

Dual couplings of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein

1991 • 72 citations

5-HT1A and histamine H1 receptors in HeLa cells stimulate phosphoinositide hydrolysis and phosphate uptake via distinct G protein pools.

1991 • 69 citations

Agonist-dependent, cholera toxin-catalyzed ADP-ribosylation of pertussis toxin-sensitive G-proteins following transfection of the human alpha 2-C10 adrenergic receptor into rat 1 fibroblasts. Evidence for the direct interaction of a single receptor with two pertussis toxin-sensitive G-proteins, Gi2 and Gi3.

1991 • 68 citations

Multiple Gi protein subtypes regulate a single effector mechanism.

1991 • 67 citations

Electrophysiological Investigation of the Adaptive Response of the 5-HT System to the Administration of 5-HT1A Receptor Agonists

1990 • 62 citations

A transfected m5 muscarinic acetylcholine receptor stimulates phospholipase A2 by inducing both calcium influx and activation of protein kinase C.

1990 • 58 citations

Electrophysiological Investigation of the Adaptive Response of the 5-HT System to the Administration of 5-HT1A Receptor Agonists

1990 • 56 citations

The Human 5-HT1A Receptor Expressed in HeLa Cells Stimulates Sodium-dependent Phosphate Uptake via Protein Kinase C

1989 • 54 citations

5-HT1A receptor agonists inhibit carbachol-induced stimulation of phosphoinositide turnover in the rat hippocampus

1988 • 52 citations

The rat α₂‐C4 adrenergic receptor gene encodes a novel pharmacological subtype

1991 • 51 citations

Intracellular Ca2+ and protein kinase C interact to regulate alpha 1-adrenergic- and bradykinin receptor-stimulated phospholipase A2 activation in Madin-Darby canine kidney cells

1991 • 50 citations

Tissue-dependent association of muscarinic acetylcholine receptors with guanine nucleotide-binding regulatory proteins.

1991 • 35 citations

Short-term regulation of Na+/K+ adenosine triphosphatase by recombinant human serotonin 5-HT1A receptor expressed in HeLa cells.

1990 • 33 citations

Identification of the ligand-binding subunit of the human 5-hydroxytryptamine1A receptor with N-(p-azido-m-[125I] iodophenethyl)spiperone, a high affinity radioiodinated photoaffinity probe.

1989 • 27 citations

Deleted Work

1955 • 0 citations