Centrally acting hypotensive agents with affinity for 5‐HT_1A binding sites inhibit forskolin‐stimulated adenylate cyclase activity in calf hippocampus

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

1980 • 1,579 citations

Multiple serotonin receptors: differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol.

1979 • 1,321 citations

Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine

1986 • 1,255 citations

8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site

1983 • 869 citations

Electrophysiological responses of serotoninergic dorsal raphe neurons to 5‐HT_1A and 5‐HT_1B agonists

1987 • 838 citations

The Classification of Adrenoceptors (Adrenergic Receptors). An Evaluation from the Standpoint of Receptor Theory

1972 • 812 citations

Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PAT

1983 • 759 citations

Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites

1986 • 686 citations

Discrimination of Multiple [³H]5‐Hydroxytryptamine Binding Sites by the Neuroleptic Spiperone in Rat Brain

1981 • 629 citations

The binding of serotonergic ligands to the porcine choroid plexus: Characterization of a new type of serotonin recognition site

1984 • 598 citations

Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: Radioligand binding studies with [3H]5-HT, [3H]8-OH-DPAT, (−)[125I]iodocyanopindolol, [3H]mesulergine and [3H]Ketanserin

1985 • 581 citations

Binding characteristics of a radiolabeled agonist and antagonist at central nervous system alpha noradrenergic receptors.

1977 • 544 citations

The classification of drugs and drug receptors in isolated tissues.

1984 • 474 citations

Characterization of the 5-hydroxytryptamine1a receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig and rat hippocampal membranes.

1986 • 420 citations

Characterization of a novel 3H-5-hydroxytryptamine binding site subtype in bovine brain membranes

1987 • 406 citations

Serotonin receptors in the human brain. I. Characterization and autoradiographic localization of 5-HT1A recognition sites. Apparent absence of 5-HT1B recognition sites

1986 • 386 citations

Selective interaction of novel anxiolytics with 5-hydroxytryptamine1A receptors

1985 • 367 citations

Characterization of the 5-HTIB recognition site in rat brain: Binding studies with (−)[125I]Iodocyanopindolol

1985 • 281 citations

Cardiovascular Response to 8-Hydroxy-2-(di-n-Propylamino) Tetralin (8-OH-DPAT) in the Rat: Site of Action and Pharmacological Analysis

1987 • 213 citations

5-HT1A-receptors mediate stimulation of adenylate cyclase in rat hippocampus

1986 • 197 citations

Molecular pharmacology of 5-HT1D recognition sites: Radioligand binding studies in human, pig and calf brain membranes

1988 • 177 citations

The behavioural response to 5-HT receptor agonists and subtypes of the central 5-HT receptor

1985 • 170 citations

5-HT1B receptors are negatively coupled with adenylate cyclase in rat substantia nigra

1988 • 160 citations

Piperazine derivatives including the putative anxiolytic drugs, buspirone and ipsapirone, are agonists at 5-HT1A receptors negatively coupled with adenylate cyclase in hippocampal neurons

1987 • 136 citations

Evidence that the putative 5-HT1A receptor agonists, 8-OH-DPAT and ipsapirone, have a central hypotensive action that differs from that of clonidine in anaesthetised cats

1987 • 130 citations

Disposition and pharmacological effects of m-Chlorophenylpiperazine in rats

1981 • 127 citations

The 5-hydroxytryptamine 5-HT1D receptor subtype is negatively coupled to adenylate cyclase in calf substantia nigra

1988 • 126 citations

Pharmacological characterization of two 5-hydroxytryptamine receptors coupled to adenylate cyclase in guinea pig hippocampal membranes.

1987 • 124 citations

Visualization of a novel serotonin recognition site (5-HT1D) in the human brain by autoradiography

1988 • 105 citations

Spiroxatrine: A selective serotonin1A receptor antagonist

1986 • 104 citations

Two 5-HT receptors linked to adenylate cyclase in guinea pig hippocampus are discriminated by 5-carboxamidotryptamine and spiperone

1985 • 102 citations

Species variations in RU 24969 interactions with non-5-HT1A binding sites

1986 • 98 citations

Pharmacological analysis of muscarinic receptors coupled to oxyntic cell secretion in the mouse stomach

1985 • 91 citations

5-HT1D receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in calf substantia nigra

1988 • 81 citations

Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT1A subtype and for ?1-adrenoceptor binding sites

1987 • 78 citations

5-HT-la and 5-HT-lb selectivity of two phenylpiperazine derivatives: Evidence for 5-HT-lb heterogeneity

1985 • 78 citations

Acute administration of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), a selective 5-HT-receptor agonist, causes a biphasic blood pressure response and a bradycardia in the normotensive Sprague-Dawley rat and in the spontaneously hypertensive rat

1985 • 75 citations

Evidence for a central depressor action of postsynaptic α1-adrenergic receptor antagonists

1981 • 69 citations

Spiperone differentiates multiple 5-hydroxytryptamine responses in rat hippocampal slices in vitro

1985 • 66 citations

Dissociation constants of serotonin agonists in the canine basilar artery correlate to Ki values at the 5-HT1A binding site.

1986 • 66 citations

Central 5-HT1A Receptors and the Mechanism of the Central Hypotensive Effect of (+)8-OH-DPAT, DP-5-CT, R28935, and Urapidil

1988 • 62 citations

Inhibition of forskolin-stimulated adenylate cyclase activity by 5-HT receptor agonists

1985 • 58 citations

[3H]WB4101 labels the 5-HT1A serotonin receptor subtype in rat brain. Guanine nucleotide and divalent cation sensitivity.

1985 • 54 citations

Canine basilar artery contractions mediated by 5-hydroxytryptamine1A receptors.

1986 • 51 citations

Effects of urapidil, clonidine, prazosin and propranolol on autonomic nerve activity, blood pressure and heart rate in anaesthetized rats and cats

1985 • 47 citations

(−)-Propranolol and (±)-cyanopindolol are mixed agonists-antagonists at serotonin autoreceptors in the hippocampus of the rat brain

1987 • 41 citations

Cardiovascular effects and interaction with adrenoceptors of urapidil.

1985 • 41 citations

[3H]dihydroergotamine as a high-affinity, slowly dissociating radioligand for 5-HT1B binding sites in rat brain membranes: evidence for guanine nucleotide regulation of agonist affinity states.

1987 • 41 citations

The effects of ketanserin, methysergide and LY 53857 on sympathetic nerve activity

1985 • 39 citations

A comparison of the effects of doxazosin and alfuzosin with those of urapidil on preganglionic symphathetic nerve activity in anaesthetised cats

1986 • 36 citations

Tryptophan analogs. 1. Synthesis and antihypertensive activity of positional isomers

1982 • 34 citations

Hypotensive activity of serotonin receptor agonists in rats is related to their affinity for 5-HT1 receptors

1983 • 34 citations

[3H]Spiroxatrine labels a serotonin1A-like site in the rat hippocampus

1987 • 32 citations

Neurochemical and behavioural evidence for an agonist action of 1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl) piperazine (LY 165163) at central 5-HT receptors

1987 • 30 citations

Hypotensive action of 8-hydroxy-2-(di-N-propylamino)tetralin (8-OH-DPAT) in spontaneously hypertensive rats.

1985 • 30 citations

Reduction in blood pressure, sympathetic nerve discharge and centrally evoked pressor responses by methysergide in anesthetized cats

1977 • 24 citations

[Studies on the influence of the antihypertensive drug urapidil on blood circulation and its regulation in animal experiments (author's transl)].

1977 • 24 citations

LY165163 and 8-OH-DPAT have agonist effects on a serotonin responsive muscle of Aplysia

1987 • 5 citations

Hypotensive properties of benzodioxane derivatives structurally related to R 28935. Comparison of activity with some receptor affinities.

1982 • 4 citations