The selective 5-HT1A antagonist radioligand [3H]WAY 100635 labels both G-protein-coupled and free 5-HT1A receptors in rat brain membranes

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

REGIONAL STUDIES OF CATECHOLAMINES IN THE RAT BRAIN‐I

1966 • 5,429 citations

Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PAT

1983 • 759 citations

5-Hydroxytryptamine receptors

2001 • 693 citations

Molecular biology of 5-HT receptors

1994 • 679 citations

Serotonergic component of neuroleptic receptors

1978 • 621 citations

The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT1A receptor

1988 • 594 citations

5‐Hydroxytryptamine Receptors

1993 • 524 citations

Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats

1986 • 513 citations

An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins

1987 • 509 citations

[³H]8‐Hydroxy‐2‐(Di‐n‐Propylamino)Tetralin Binding to Pre‐ and Postsynaptic 5‐Hydroxytryptamine Sites in Various Regions of the Rat Brain

1985 • 458 citations

Cloning, functional expression, and mRNA tissue distribution of the rat 5-hydroxytryptamine1A receptor gene.

1990 • 444 citations

Adrenergic Receptors as Models for G Protein-Coupled Receptors

1992 • 340 citations

Characteristics of central 5-HT receptors and their adaptive changes following intracerebral 5,7-dihydroxytryptamine administration in the rat.

1978 • 336 citations

Direct Immunohistochemical Evidence of the Existence of 5‐HT_1A Autoreceptors on Serotoninergic Neurons in the Midbrain Raphe Nuclei

1990 • 274 citations

WAY100135: a novel, selective antagonist at presynaptic and postsynaptic 5-HT1A receptors

1993 • 223 citations

Silent 5-HT1A receptor antagonists: utility as research tools and therapeutic agents

1993 • 194 citations

3H-TVX Q 7821: identification of 5-HT1 binding sites as target for a novel putative anxiolytic

1985 • 174 citations

Autoradiography of serotonin receptor subtypes in the central nervous system

1991 • 157 citations

Selective in vivo labelling of brain 5-HT1A receptors by [3H]WAY 100635 in the mouse

1994 • 106 citations

Production of specific anti-rat 5-HT1A receptor antibodies in rabbits injected with a synthetic peptide

1990 • 98 citations

Physical evidence of the coupling of solubilized 5-HT1A binding sites with G regulatory proteins

1990 • 78 citations

(?)Tertatolol is a potent antagonist at pre- and postsynaptic serotonin 5-HT1A receptors in the rat brain

1993 • 73 citations

Further assessment of the antagonist properties of the novel and selective 5-HT1A receptor ligands (+)-WAY 100 135 and SDZ 216–525

1993 • 70 citations

Differentiation of pre- and postsynaptic high affinity serotonin receptor binding sites using physico-chemical parameters and modifying agents

1986 • 59 citations

125I-Bolton-Hunter-8-methoxy-2-[N-propyl-N-propylamino]tetralin as a new selective radioligand of 5-HT1A sites in the rat brain. In vitro binding and autoradiographic studies.

1988 • 52 citations

S 14506: A novel, potent, high‐efficacy 5‐HT_1A agonist and potential anxiolytic agent

1992 • 51 citations

The selective labelling of central 5-HT1A receptor binding sites by [3H]5-methoxy-3-(di-n-propylamino) chroman

1987 • 48 citations

Characterization of recombinant human serotonin 5HT1A receptors expressed in Chinese Hamster Ovary cells

1993 • 45 citations

Synthesis of (R,S)-trans-8-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)amino]tetralin (trans 8-OH-PIPAT): a new 5-HT1A receptor ligand

1993 • 44 citations

Biochemical and electrophysiological evidence for an agonist action of CM 57493 at pre- and postsynaptic 5-hydroxytryptamine1A receptors in brain.

1989 • 40 citations

New methoxy-chroman derivatives, 4[N-(5-methoxy-chroman-3-yl)N- propylamino]butyl-8-azaspiro-(4,5)-decane-7,9-dione [(+/-)-S 20244] and its enantiomers, (+)-S 20499 and (-)-S 20500, with potent agonist properties at central 5-hydroxytryptamine1A receptors.

1993 • 40 citations

Dual effects of mastoparan on intracellular free Ca²⁺ concentrations in human astrocytoma cells

1994 • 35 citations

EFFECTS OF ACUTE AND CHRONIC TREATMENT WITH THE SELECTIVE 5-HT1A RECEPTOR ANTAGONIST WAY-100635 ON HIPPOCAMPAL 5-HT RELEASE IN-VIVO

1994 • 33 citations

Indirect effect of guanine nucleotides on antagonist binding to A1 adenosine receptors: occupation of cryptic binding sites by endogenous vesicular adenosine.

1992 • 29 citations

Differential inactivation and G protein reconstitution of subtypes of [3H]5-hydroxytryptamine binding sites in brain.

1988 • 28 citations

Comparative analysis of the vagal stimulation of gastric acid secretion in rodent isolated stomach preparations

1994 • 28 citations

Interactions of lesopitron (E-4424) with central 5-HT1A receptors: in vitro and in vivo studies in the rat

1994 • 21 citations

[3H]5-Methyl-urapidil labels 5-HT1A receptors and α1-adrenoceptors in the rat CNS. In vitro binding and autoradiographic studies

1991 • 18 citations

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