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The Future of Genetic Studies of Complex Human Diseases

1996 • 5,355 citations

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

1995 • 5,291 citations

Large-Scale Identification, Mapping, and Genotyping of Single-Nucleotide Polymorphisms in the Human Genome

1998 • 2,163 citations

Searching for genetic determinants in the new millennium

2000 • 1,878 citations

Linkage disequilibrium in the human genome

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A Polydiagnostic Application of Operational Criteria in Studies of Psychotic Illness

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Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

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1990 • 1,335 citations

Variations on a Theme: Cataloging Human DNA Sequence Variation

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Bipolar affective disorders linked to DNA markers on chromosome 11

1987 • 826 citations

Untitled

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A candidate prostate cancer susceptibility gene at chromosome 17p

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Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21

1998 • 542 citations

Identification of a Major Susceptibility Locus on Chromosome 6p and Evidence for Further Disease Loci Revealed by a Two Stage Genome-Wide Search in Psoriasis

1997 • 523 citations

How many diseases does it take to map a gene with SNPs?

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A Simple Genetic Basis for a Complex Psychological Trait in Laboratory Mice

1995 • 447 citations

Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish

1989 • 443 citations

Psychotic Illness in Patients Diagnosed with Velo-Cardio-Facial Syndrome and Their Relatives

1994 • 434 citations

Linkage Disequilibrium and the Search for Complex Disease Genes

2000 • 410 citations

A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2

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Single nucleotide polymorphisms and the future of genetic epidemiology

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Sequential strategy to identify a susceptibility gene for schizophrenia: Report of potential linkage on chromosome 22q12‐q13.1: Part 1

1994 • 387 citations

Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans

1999 • 386 citations

Continuity and Discontinuity of Affective Disorders and Schizophrenia

1993 • 379 citations

Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene.

1994 • 378 citations

Bipolar spectrum disorders in patients diagnosed with velo-cardio- facial syndrome: does a hemizygous deletion of chromosome 22q11 result in bipolar affective disorder?

1996 • 368 citations

The Familial Transmission of Bipolar Illness

1987 • 366 citations

Linkage disequilibrium mapping of complex disease: fantasy or reality?

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Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect.

1995 • 347 citations

A Controlled Family Study of Chronic Psychoses

1988 • 347 citations

A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus

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A possible vulnerability locus for bipolar affective disorder on chromosome 21q22.3

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A Genomewide Screen for Schizophrenia Genes in an Isolated Finnish Subpopulation, Suggesting Multiple Susceptibility Loci

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Genetic linkage and complex diseases, with special reference to psychiatric disorders

1990 • 283 citations

Evidence for linkage of a candidate chromosome 1 region to human systemic lupus erythematosus.

1997 • 279 citations

A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22

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Genome scan of European-American schizophrenia pedigrees: Results of the NIMH genetics initiative and millennium consortium

1998 • 278 citations

A locus for bipolar affective disorder on chromosome 4p

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The Continuum of Psychosis and Its Genetic Origins

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Genetic mapping using haplotype, association and linkage methods suggests a locus for severe bipolar disorder (BPI) at 18q22-q23

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Handbook of Affective Disorders.

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New Target Regions for Human Hypertension via Comparative Genomics

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1996 • 225 citations

Genome-wide search for linkage of bipolar affective disorders in a very large pedigree derived from a homogeneous population in Quebec points to a locus of major effect on chromosome 12q23-q24

1999 • 221 citations

Association Mapping of Disease Loci, by Use of a Pooled DNA Genomic Screen

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Initial genome scan of the NIMH genetics initiative bipolar pedigrees: Chromosomes 1, 6, 8, 10, and 12

1997 • 218 citations

Patterns of maternal transmission in bipolar affective disorder.

1995 • 216 citations

Linkage of Familial Schizophrenia to Chromosome 13q32

1999 • 215 citations

A manic depressive history

1996 • 211 citations

Meta‐analysis of genome searches

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Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach

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Combining Cognitive Testing and Informant Report to Increase Accuracy in Screening for Dementia

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The genetically isolated populations of Finland and Sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes

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Neuropsychology of bipolar disorder

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Genetics of Schizophrenia and the New Millennium: Progress and Pitfalls

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A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish

1996 • 173 citations

A Genetic Linkage Map of the Baboon (Papio hamadryas) Genome Based on Human Microsatellite Polymorphisms

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A genome-wide autosomal screen for schizophrenia susceptibility loci in 71 families with affected siblings: support for loci on chromosome 10p and 6

2000 • 172 citations

Evidence for Involvement of the Type 1 Angiotensin II Receptor Locus in Essential Hypertension

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Chromosome 18 DNA markers and manic-depressive illness : evidence for a susceptibility gene

1994 • 169 citations

Schizoaffective illness, schizophrenia and affective disorders: morbidity risk and genetic transmission

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Diminished support for linkage between manic depressive illness and X–chromosome markers in three Israeli pedigrees

1993 • 162 citations

Quantitative trait loci analysis affecting contextual conditioning in mice

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A schizophrenia locus may be located in region 10p15-p11

1998 • 148 citations

Evidence for linkage disequilibrium between the dopamine transporter and bipolar disorder

2001 • 146 citations

Support for a Chromosome 18p Locus Conferring Susceptibility to Functional Psychoses in Families with Schizophrenia, by Association and Linkage Analysis

1998 • 145 citations

Bipolar disorder and panic disorder in families: an analysis of chromosome 18 data.

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Evidence of a predisposing locus to bipolar disorder on Xq24-q27.1 in an extended Finnish pedigree.

1995 • 142 citations

Maternal inheritance and chromosome 18 allele sharing in unilineal bipolar illness pedigrees

1996 • 138 citations

Detection of expanded CAG repeats in Bipolar Affective Disorder using the repeat expansion detection (RED) method

1995 • 138 citations

Genetic Approaches to Mental Disorders

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Initial Genome Scan of the NIMH Genetics Initiative Bipolar Pedigrees: Chromosomes 4, 7, 9, 18, 19, 20, and 21q

1997 • 133 citations

Familial Cosegregation of Major Affective Disorder and Darier's Disease (Keratosis Follicularis)

1994 • 133 citations

Use of keyword hierarchies to interpret gene expression patterns

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Confirmation of association between expanded CAG/CTG repeats and both schizophrenia and bipolar disorder

1996 • 131 citations

Evaluation of linkage of bipolar affective disorder to chromosome 18 in a sample of 57 German families

1999 • 129 citations

Evidence for a role of phospholipase C-γ1 in the pathogenesis of bipolar disorder

1998 • 127 citations

Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q.

1996 • 124 citations

Positional Cloning of Disease Genes: Advantages of Genetic Isolates

1999 • 120 citations

Mathematical limits of multilocus models: the genetic transmission of bipolar disorder.

1995 • 119 citations

Significant linkage between bipolar affective disorder and chromosome 12q24

1998 • 119 citations

Increased levels of a mitochondrial DNA deletion in the brain of patients with bipolar disorder

1997 • 118 citations

A Linkage Study of Bipolar Illness

1997 • 118 citations

Dynamic mutations and psychiatric genetics

1996 • 114 citations

A Comprehensive Linkage Analysis of Chromosome 21q22 Supports Prior Evidence for a Putative Bipolar Affective Disorder Locus

1999 • 110 citations

PARP alleles within the linked chromosomal region are associated with systemic lupus erythematosus

1999 • 110 citations

Candidate genes in psychiatry: An epidemiological perspective

1993 • 108 citations

Possible locus for bipolar disorder near the dopamine transporter on chromosome 5

1996 • 107 citations

Adequacy of single‐locus approximations for linkage analyses of oligogenic traits

1992 • 107 citations

Linkage studies of bipolar disorder in the region of the Darier's disease gene on chromosome 12q23‐24.1

1995 • 107 citations

Association studies in psychiatric genetics

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Turning point in the design of linkage studies of schizophrenia

1994 • 104 citations

Initial genome screen for bipolar disorder in the NIMH genetics initiative pedigrees: Chromosomes 2, 11, 13, 14, and X

1997 • 104 citations

Population cytogenetic investigation of newborns in Moscow

1974 • 103 citations

Linkage of Bipolar Affective Disorder to Chromosome 18 Markers in a New Pedigree Series

1997 • 100 citations

Genetic Analysis of Complex Diseases

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Linkage of a composite inhibitory phenotype to a chromosome 22q locus in eight Utah families

1999 • 94 citations

Two-Locus Admixture Linkage Analysis of Bipolar and Unipolar Affective Disorder Supports the Presence of Susceptibility Loci on Chromosomes 11p15 and 21q22

1997 • 93 citations

Chromosomal Aberrations and Schizophrenia

1992 • 84 citations

A genome-wide search for chromosomal loci linked to mental health wellness in relatives at high risk for bipolar affective disorder among the Old Order Amish

1998 • 83 citations

Suggestive evidence of a locus on chromosome 10p using the NIMH genetics initiative bipolar affective disorder pedigrees

2000 • 80 citations

Linkage analysis of families with bipolar illness and chromosome 18 markers

1996 • 79 citations

Support for the possible locus on chromosome 4p16 for bipolar affective disorder

1998 • 78 citations

Full-Genome Scan for Linkage in 50 Families Segregating the Bipolar Affective Disease Phenotype

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Multi-Locus Nonparametric Linkage Analysis of Complex Trait Loci with Neural Networks

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1987 • 73 citations

Tryptophan hydroxylase polymorphism and suicidality in unipolar and bipolar affective disorders: a multicenter association study

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Serial analysis of gene expression in the frontal cortex of patients with bipolar disorder

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The Future of Path Analysis, Segregation Analysis, and Combined Models for Genetic Dissection of Complex Traits

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Two‐stage global search designs for linkage analysis using pairs of affected relatives

1996 • 67 citations

Reich, D. E., Cargill, M. and Bolk, S. et al.. Linkage disequilibrium in the human genome. Nature, 411: 199-204

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Neuroanatomical studies on bipolar disorder

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Two-stage global search designs for linkage analysis using pairs of affected relatives

1996 • 60 citations

Commentary:The role of meta-analysis in linkage studies of complex traits

1997 • 60 citations

Genetic Linkage in Mental Illness

1990 • 60 citations

Two commonly expanded CAG/CTG repeat loci: involvement in affective disorders?

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Bipolar disorder: Evidence for a major locus

1995 • 58 citations

Efficient strategies for genome scanning using maximum-likelihood affected-sib-pair analysis.

1997 • 58 citations

A look at linkage disequilibrium

2000 • 58 citations

Parent-of-origin effect in transmission of bipolar disorder

1996 • 57 citations

Analysis of chromosome 18 DNA markers in multiplex pedigrees with manic depression

1996 • 57 citations

A possible susceptibility locus for bipolar affective disorder in chromosomal region 10q25–q26

2001 • 54 citations

Meta-analysis methodology for combining non-parametric sibpair linkage results: Genetic homogeneity and identical markers

1998 • 54 citations

What Is Significant in Whole-Genome Linkage Disequilibrium Studies?

1997 • 51 citations

No association between chromosome-18 markers and lithiumresponsive affective disorders

1996 • 51 citations

Exclusion of the Darier's disease gene, ATP2A2, as a common susceptibility gene for bipolar disorder

2000 • 50 citations

Mitochondrial Genetic Analyses Suggest Selection against Maternal Lineages in Bipolar Affective Disorder

1999 • 50 citations

A follow-up linkage study supports evidence for a bipolar affective disorder locus on chromosome 21q22

2001 • 49 citations

The search for complex disease genes: fault by linkage or fault by association?

2001 • 47 citations

Type I bipolar disorder associated with a fragile site on chromosome 1

1995 • 46 citations

Chromosomal Aberrations and Bipolar Affective Disorder

1994 • 45 citations

Mental disorders in diabetic patients with mitochondrial transfer RNALeu (UUR) mutation at position 3243

1997 • 41 citations

Nonparametric simulation-based statistical analyses for bipolar affective disorder locus on chromosome 21q22.3

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Update on chromosomal locations for psychiatric disorders: Report of the interim meeting of chromosome workshop chairpersons from the VIIth World Congress of Psychiatric Genetics, Monterey, California, October 14-18, 1999

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Manic depressive illness is linked to factor IX in a French pedigree.

1992 • 39 citations

The impact of phenotypic variation on genetic analysis: application to X‐linkage in manic‐depressive illness

1990 • 38 citations

No Evidence for Significant Linkage between Bipolar Affective Disorder and Chromosome 18 Pericentromeric Markers in a Large Series of Multiplex Extended Pedigrees

1998 • 38 citations

Pharmacogenetics of lithium response in bipolar disorder.

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Psychiatric genetics: Research challenges and pathways forward

1994 • 37 citations

Molecular Genetics: Applications to the Clinical Neurosciences

1987 • 36 citations

Chromosome workshops 1998: Current state of psychiatric linkage

1999 • 36 citations

Evaluating the parent-of-origin effect in bipolar affective disorder

2000 • 36 citations

Lack of association between bipolar disorder and tyrosine hydroxylase

1997 • 35 citations

Neural networks and disease association studies

2001 • 34 citations

The chromosome workshops at the 5th International Congress of Psychiatric Genetics — the weight of the evidence from genome scans

1998 • 31 citations

Genetic association study in psychiatry: Analytical evaluation and a recommendation

1994 • 30 citations

Molecular Genetics and Human Disease Implications for Modern Psychiatric Research and Practice

1988 • 29 citations

Optimal strategies for mapping complex diseases in the presence of multiple loci.

1997 • 29 citations

Patterns of parental transmission and familial aggregation models in bipolar affective disorder.

1998 • 26 citations

Modern molecular genetic approaches to complex traits: implications for psychiatric disorders.

1996 • 25 citations

BPD2. An autosomal dominant form of bipolar affective disorder.

1983 • 25 citations

Genetic linkage and bipolar affective disorder: progress and pitfalls

1997 • 24 citations

Scanning the genome with 1772 microsatellite markers in search of a bipolar disorder susceptibility gene.

1996 • 24 citations

Patterns of parental transmission and familial aggregation models in bipolar affective disorder

1998 • 23 citations

Model-free vs. model-based linkage analysis: A false dichotomy?

2001 • 22 citations

Genetic analysis of bipolar disorder: Summary of GAW10

1997 • 20 citations

Case-control association studies in complex traits–the end of an era?

1997 • 19 citations

Tyrosine hydroxylase polymorphism and phenotypic heterogeneity in bipolar affective disorder: A multicenter association study

1999 • 19 citations

Affected-Sib-Pair Interval Mapping and Exclusion for Complex Genetic Traits:

1996 • 18 citations

Linkage Analyses in Type I Diabetes mellitus Using CASPAR, a Software and Statistical Program for Conditional Analysis of Polygenic Diseases

1997 • 18 citations

Maternal inheritance of manic depression in hemizygotes for the G6PD-Mediterranean mutation. Indirect evidence for Xq28 transmission in Sardinia

1999 • 14 citations

Association studies in Psychiatry: a season of discontent

1997 • 13 citations

Phenotypes and genetic analysis of psychiatric and neuropsychiatric traits

2001 • 11 citations

Complex Inheritance and Localizing Disease Genes

1999 • 10 citations

Linkage analysis of complex disorders with multiple phenotypic categories: Simulation studies and application to bipolar disorder data

1997 • 3 citations

Modeling the phenotype in parametric linkage analysis of bipolar disorder

1997 • 3 citations

Probabilistic diagnosis in linkage analysis of bipolar disorder: Putting weights on the fringe

1997 • 1 citations

Deleted Work

1955 • 0 citations