Optimal strategies for mapping complex diseases in the presence of multiple loci.

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1995 • 3,985 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Identification of the breast cancer susceptibility gene BRCA2

1995 • 3,581 citations

Genetic Dissection of Complex Traits

1994 • 3,497 citations

Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21

1990 • 2,505 citations

Localization of a Breast Cancer Susceptibility Gene, BRCA2 , to Chromosome 13q12-13

1994 • 1,884 citations

Linkage strategies for genetically complex traits. I. Multilocus models.

1990 • 1,335 citations

A genome-wide search for human type 1 diabetes susceptibility genes

1994 • 1,294 citations

Systematic Population-Based Assessment of Cancer Risk in First-Degree Relatives of Cancer Probands

1994 • 1,029 citations

Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14

1992 • 941 citations

Complete multipoint sib-pair analysis of qualitative and quantitative traits.

1995 • 929 citations

The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds

1996 • 849 citations

A Familial Alzheimer's Disease Locus on Chromosome 1

1995 • 810 citations

A genome–wide search for human non–insulin–dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2

1996 • 601 citations

Asymptotic properties of affected-sib-pair linkage analysis.

1993 • 378 citations

AGE AT ONSET AS AN INDICATOR OF FAMILIAL RISK OF BREAST CANCER

1990 • 370 citations

Genetic analysis of type 1 diabetes using whole genome approaches.

1995 • 256 citations

Two-trait-locus linkage analysis: a powerful strategy for mapping complex genetic traits.

1993 • 175 citations

Two-locus maximum lod score analysis of a multifactorial trait: joint consideration of IDDM2 and IDDM4 with IDDM1 in type 1 diabetes.

1995 • 145 citations

FAMILIAL BREAST CANCER IN A POPULATION-BASED SERIES

1986 • 122 citations

Two-locus disease models with two marker loci: the power of affected-sib-pair tests.

1994 • 71 citations

Some epistatic two-locus models of disease. I. Relative risks and identity-by-descent distributions in affected sib pairs.

1981 • 57 citations

Interactive effect of two candidate genes in a disease: extension of the marker-association-segregation chi(2) method.

1994 • 41 citations

Two‐disease locus model: Sib pair method using information on both HLA and Gm

1986 • 22 citations