Association Mapping of Disease Loci, by Use of a Pooled DNA Genomic Screen

The Future of Genetic Studies of Complex Human Diseases

1996 • 5,355 citations

Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).

1993 • 3,693 citations

A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis

1996 • 3,682 citations

Genetic Dissection of Complex Traits

1994 • 3,497 citations

A comprehensive genetic map of the human genome based on 5,264 microsatellites

1996 • 2,983 citations

The 1993–94 Généthon human genetic linkage map

1994 • 1,870 citations

A second-generation linkage map of the human genome

1992 • 1,721 citations

A genome-wide search for human type 1 diabetes susceptibility genes

1994 • 1,294 citations

HLA and Disease Associations

1985 • 893 citations

Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus

1995 • 749 citations

Mendelian Inheritance in Man: A Catalog of Human Genes and Genetic Disorders

1998 • 693 citations

A full genome search in multiple sclerosis

1996 • 666 citations

A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex

1996 • 650 citations

A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22

1996 • 638 citations

A genome–wide search for human non–insulin–dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2

1996 • 601 citations

Linkage disequilibrium mapping in isolated founder populations: diastrophic dysplasia in Finland

1992 • 571 citations

A Comprehensive Human Linkage Map with Centimorgan Density

1994 • 547 citations

MHC Class-II Molecules and Autoimmunity

1991 • 521 citations

A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci.

1995 • 460 citations

HLA and disease

1977 • 430 citations

Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome llq

1994 • 397 citations

A review of the recent epidemiological data on the worldwide incidence of Type 1 (insulin-dependent) diabetes mellitus

1993 • 387 citations

A Comprehensive Genetic Linkage Map of the Human Genome

1992 • 355 citations

Mapping disease genes: family-based association studies.

1995 • 345 citations

General score tests for associations of genetic markers with disease using cases and their parents

1996 • 334 citations

Chromosome–specific microsatellite sets for fluorescence–based, semi–automated genome mapping

1994 • 304 citations

Evolutionary Genetics of the Major Histocompatibility Complex

1994 • 255 citations

Detection of Obesity QTLs on Mouse Chromosomes 1 and 7 by Selective DNA Pooling

1996 • 243 citations

Polygenic disease: methods for mapping complex disease traits

1995 • 239 citations

A Comprehensive Genetic Linkage Map of the Human Genome

1992 • 213 citations

Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31–q33

1995 • 211 citations

A putative vulnerability locus to multiple sclerosis maps to 5p14–p12 in a region syntenic to the murine locus Eae2

1996 • 209 citations

THE EFFECT OF A SELECTED LOCUS ON LINKED NEUTRAL LOCI

1977 • 208 citations

Identification of repeat sequence heterogeneity at the polymorphic short tandem repeat locus HUMTH01[AATG]n and reassignment of alleles in population analysis by using a locus-specific allelic ladder.

1993 • 203 citations

Novel inherited mutations and variable expressivity of BRCA1 alleles, including the founder mutation 185delAG in Ashkenazi Jewish families.

1995 • 191 citations

HLA and disease associations

1986 • 185 citations

A collection of tri- and tetranucleotide repeat markers used to generate high quality, high resolution human genome-wide linkage maps

1995 • 182 citations

Use of a DNA pooling strategy to identify a human obesity syndrome locus on chromosome 15

1995 • 180 citations

A locus on chromosome 15q26 (IDDM3) produces susceptibility to insulin-dependent diabetes mellitus

1994 • 175 citations

Panning for gold: genome-wide scanning for linkage in type 1 diabetes

1996 • 174 citations

Statistical properties of the haplotype relative risk

1989 • 169 citations

Pendred syndrome maps to chromosome 7q21-34 and is caused by an intrinsic defect in thyroid iodine organification

1996 • 161 citations

Simplified hot start PCR

1996 • 161 citations

Mendelian inheritance in man: A catalog of human genes and genetic disorders

1996 • 145 citations

Linkage disequilibrium predicts physical distance in the adenomatous polyposis coli region.

1994 • 129 citations

Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5 and IDDM8

1996 • 129 citations

Strong allelic association between the torsion dystonia gene (DYT1) andloci on chromosome 9q34 in Ashkenazi Jews.

1992 • 125 citations

Discordant patterns of linkage disequilibrium of the peptide-transporter loci within the HLA class II region.

1995 • 119 citations

Genetic Variation and Human Disease: Principles and Evolutionary Approaches

1997 • 108 citations

Toward fully automated genotyping: genotyping microsatellite markers by deconvolution.

1995 • 108 citations

Approach to genotyping errors caused by nontemplated nucleotide addition by Taq DNA polymerase.

1995 • 105 citations

The haplotype-relative-risk (HRR) method for analysis of association in nuclear families.

1993 • 102 citations

Susceptibility to Insulin-Dependent Diabetes Mellitus Maps to a Locus (IDDM11) on Human Chromosome 14q24.3–q31

1996 • 99 citations

Localization of the hemochromatosis gene close to D6S105.

1993 • 98 citations

A cerebellar ataxia locus identified by DNA pooling to search for linkage disequilibrium in an isolated population from the Cayman Islands

1996 • 94 citations

HLA and insulin gene associations with IDDM

1989 • 93 citations

Detection of linkage disequilibrium between the myotonic dystrophy locus and a new polymorphic DNA marker.

1991 • 93 citations

Localization of predisposition to Hodgkin disease in the HLA class II region.

1994 • 90 citations

HUMAN GENE MAPPING: A COMPENDIUM

1994 • 87 citations

An autosomal recessive nonsyndromic-hearing-loss locus identified by DNA pooling using two inbred Bedouin kindreds.

1996 • 83 citations

The HOXD8 Locus (2q31) is Linked to Type I Diabetes: Interaction with Chromosome 6 and 11 Disease Susceptibility Genes

1995 • 76 citations

New polymorphic microsatellite markers place the haemochromatosis gene telomeric to D6S105

1995 • 75 citations

Novel approaches to linkage mapping

1995 • 62 citations

The Friedreich ataxia gene is assigned to chromosome 9q13-q21 by mapping of tightly linked markers and shows linkage disequilibrium with D9S15.

1990 • 54 citations

Linkage disequilibrium patterns vary with chromosomal location: a case study from the von Willebrand factor region.

1994 • 47 citations

An approach to investigating linkage for bipolar disorder using large Costa Rican pedigrees

1996 • 44 citations

Insulin-gene sharing in sib pairs with insulin-dependent diabetes mellitus: no evidence for linkage.

1988 • 42 citations

Analysis of complex human genetic traits: an ordered-notation method and new tests for mode of inheritance.

1995 • 42 citations

Linkage disequilibrium between the juvenile neuronal ceroid lipofuscinosis gene and marker loci on chromosome 16p 12.1.

1994 • 36 citations

Refining the position of Wilson disease by linkage disequilibrium with polymorphic microsatellites.

1994 • 27 citations

Linkage and sib-pair analysis reveal a potential schizophrenia susceptibility gene on chromosome 13q32

1996 • 23 citations

Evolutionary and Population Perspectives of the Human HLA Complex

1992 • 21 citations

The Role of the Human Genome Project in Disease Prevention

1994 • 20 citations

Molecular Genetic Approaches to the Analysis and Diagnosis of Human Inherited Disease: An Overview

1992 • 19 citations

Evidence for linkage disequilibrium between D16S94 and the adult onset polycystic kidney disease (PKD1) gene.

1992 • 14 citations

Genetic variation and human disease: Principles and evolutionary approaches

1994 • 14 citations

Towards fully automated genotyping: use of an X linked recessive spastic paraplegia family to test alternative analysis methods

1995 • 9 citations

Significant linkage disequilibrium between the Huntington disease gene and the loci D4S10 and D4S95 in the Dutch population.

1992 • 8 citations

Locating the cystic fibrosis gene on the basis of linkage disequilibrium with markers?

1989 • 5 citations

A map to the future

1996 • 5 citations

Linkage analysis: Inadequate for detecting susceptibility loci in complex disorders?

1994 • 1 citations