Functional genomics and target validation approaches using antisense oligonucleotide technology

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

Molecular portraits of human breast tumours

2000 • 15,445 citations

The Sequence of the Human Genome

2001 • 13,500 citations

Proteomics to study genes and genomes

2000 • 2,353 citations

Integrated Genomic and Proteomic Analyses of a Systematically Perturbed Metabolic Network

2001 • 2,058 citations

Genomics, gene expression and DNA arrays

2000 • 2,039 citations

A gene expression database for the molecular pharmacology of cancer

2000 • 1,447 citations

Protein function in the post-genomic era

2000 • 721 citations

Pleiotropic cell-division defects and apoptosis induced by interference with survivin function

1999 • 613 citations

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

2001 • 525 citations

A public database for gene expression in human cancers.

1999 • 417 citations

The Impact of Comparative Genomics on Our Understanding of Evolution

2000 • 282 citations

Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis

2000 • 275 citations

Antisense Drug Technology

2010 • 272 citations

Pathway Databases: A Case Study in Computational Symbolic Theories

2001 • 235 citations

Recursive partitioning for tumor classification with gene expression microarray data

2001 • 232 citations

Characterization of a Potent and Specific Class of Antisense Oligonucleotide Inhibitor of Human Protein Kinase C-α Expression

1999 • 222 citations

Induction of endogenous Bcl-xS through the control of Bcl-x pre-mRNA splicing by antisense oligonucleotides

1999 • 200 citations

Drug Development: The role of innovation in drug development

1997 • 172 citations

“Antisense Drug Technology. Principles, Strategies, and Applications”

2002 • 156 citations

A Constitutive Cytoprotective Pathway Protects Endothelial Cells from Lipopolysaccharide-induced Apoptosis

2001 • 109 citations

p27Kip1 is required for PTEN-induced G1 growth arrest.

2001 • 107 citations

Fully modified 2' MOE oligonucleotides redirect polyadenylation

2001 • 107 citations

Drug discovery—an operating model for a new era

2001 • 98 citations

Inhibition of Bcl-xL expression sensitizes normal human keratinocytes and epithelial cells to apoptotic stimuli

1999 • 91 citations

Pharmacokinetics and pharmacodynamics of an antisense phosphorothioate oligonucleotide targeting Fas mRNA in mice.

2001 • 69 citations

Identification of an Estrogen-inducible Phosphatase (PP5) That Converts MCF-7 Human Breast Carcinoma Cells into an Estrogen-independent Phenotype when Expressed Constitutively

2001 • 55 citations

Basic Principles of Antisense Technology

2001 • 35 citations

Piecing together the significance of splicing

2001 • 30 citations

Pharmacology of 2'-O-(2-Methoxy)ethyl- Modified Antisense Oligonucleotides

2001 • 22 citations

Pharmacokinetic Properties in Animals

2001 • 20 citations

Pre-mRNA splicing as a target for antisense oligonucleotides

1991 • 16 citations

Regulation of pre-mRNA splicing by antisense oligonucleotides.

1999 • 8 citations

Optimizing the impact of genomics on drug discovery and development

1998 • 7 citations