Activation of a GTP‐Binding Protein and a GTP‐Binding‐Protein‐Coupled Receptor Kinase (β‐Adrenergic‐Receptor Kinase‐1) by a Muscarinic Receptor m2 Mutant Lacking Phosphorylation Sites

Baculovirus expression vectors: a laboratory manual.

1992 • 1,799 citations

A Manual of Methods for Baculovirus Vectors and Insect Cell Culture Procedures.

1987 • 1,703 citations

β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function

1990 • 1,162 citations

Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments.

1986 • 781 citations

Role of βγ Subunits of G Proteins in Targeting the β-Adrenergic Receptor Kinase to Membrane-Bound Receptors

1992 • 703 citations

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.

1986 • 650 citations

Baculovirus expression vectors: A laboratory manual

1993 • 478 citations

The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase.

1993 • 467 citations

β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family

1989 • 451 citations

G protein—coupled receptor kinases

1993 • 434 citations

Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization

1988 • 429 citations

Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems.

1992 • 330 citations

Reconstitution of resolved muscarinic cholinergic receptors with purified GTP-binding proteins.

1985 • 314 citations

Mechanism of rhodopsin kinase activation

1991 • 301 citations

Reconstitutively active G protein-coupled receptors purified from baculovirus-infected insect cells.

1991 • 283 citations

Hydrophobic amino acid in the i2 loop plays a key role in receptor-G protein coupling.

1993 • 226 citations

Role of acidic amino acids in peptide substrates of the .beta.-adrenergic receptor kinase and rhodopsin kinase

1991 • 220 citations

G-protein-coupled receptor kinases

1991 • 219 citations

Sequential phosphorylation of rhodopsin at multiple sites

1993 • 204 citations

Activation by G protein beta gamma subunits of agonist- or light-dependent phosphorylation of muscarinic acetylcholine receptors and rhodopsin.

1992 • 202 citations

Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure

2005 • 185 citations

Mechanisms of muscarinic receptor action on Go in reconstituted phospholipid vesicles

1989 • 180 citations

The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2

1993 • 178 citations

Chapter 5 Interactions between photoexcited rhodopsin and light-activated enzymes in rods

1984 • 174 citations

Sequestration of muscarinic acetylcholine receptor m2 subtypes. Facilitation by G protein-coupled receptor kinase (GRK2) and attenuation by a dominant-negative mutant of GRK2.

1994 • 150 citations

Purification of the muscarinic acetylcholine receptor from porcine brain.

1985 • 142 citations

Beta-adrenergic receptor kinase. Agonist-dependent receptor binding promotes kinase activation.

1993 • 127 citations

Serine- and threonine-rich domain regulates internalization of muscarinic cholinergic receptors.

1993 • 109 citations

Mechanistic studies on the phosphorylation of photoexcited rhodopsin

1988 • 105 citations

G Protein‐Coupled Receptor Kinases

1994 • 104 citations

Binding of wild type and chimeric arrestins to the m2 muscarinic cholinergic receptor

1993 • 96 citations

Phosphorylation and desensitization of human m2 muscarinic cholinergic receptors by two isoforms of the beta-adrenergic receptor kinase

1993 • 96 citations

Expression and characterization of two beta-adrenergic receptor kinase isoforms using the baculovirus expression system.

1993 • 88 citations

Mutational analysis of muscarinic acetylcholine receptors: Structural basis of ligand/receptor/g protein interactions

1993 • 84 citations

Activation by G protein beta gamma subunits of beta-adrenergic and muscarinic receptor kinase.

1993 • 83 citations

Dual regulation by G proteins of agonist‐dependent phosphorylation of muscarinic acetylcholine receptors

1990 • 80 citations

Deletion analysis of the mouse m1 muscarinic acetylcholine receptor: effects on phosphoinositide metabolism and down-regulation

1989 • 77 citations

Synergistic activation of a G protein-coupled receptor kinase by G protein beta gamma subunits and mastoparan or related peptides.

1994 • 67 citations

Reconstitution of the purified porcine atrial muscarinic acetylcholine receptor with purified porcine atrial inhibitory guanine nucleotide binding protein

1987 • 63 citations

Transducin inhibition of light-dependent rhodopsin phosphorylation: evidence for beta gamma subunit interaction with rhodopsin.

1988 • 61 citations

Location of agonist‐dependent‐phosphorylation sites in the third intracellular loop of muscarinic acetylcholine receptors (m2 subtype)

1994 • 61 citations

Internalization of the Hm1 muscarinic cholinergic receptor involves the third cytoplasmic loop

1990 • 52 citations

Major pertussis‐toxin‐sensitive GTP‐binding protein of bovine lung

1988 • 43 citations

Effects of magnesium ion on the interaction of atrial muscarinic acetylcholine receptors and GTP-binding regulatory proteins

1992 • 41 citations

Interaction of atrial muscarinic receptors with three kinds of GTP-binding proteins

1990 • 27 citations