Activation by G protein beta gamma subunits of agonist- or light-dependent phosphorylation of muscarinic acetylcholine receptors and rhodopsin.

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Diversity of G Proteins in Signal Transduction

1991 • 1,990 citations

Muscarinic Receptor Subtypes

1990 • 1,346 citations

The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart

1987 • 1,186 citations

β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function

1990 • 1,162 citations

Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments.

1986 • 781 citations

Rhodopsin content in the outer segment membranes of bovine and frog retinal rods

1974 • 730 citations

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.

1986 • 650 citations

The molecular basis of muscarinic receptor diversity

1989 • 544 citations

Molecular Properties of the Muscarinic Acetylcholine Receptor

1987 • 478 citations

Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein).

1987 • 478 citations

β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family

1989 • 451 citations

Light-dependent phosphorylation of rhodopsin: number of phosphorylation sites

1982 • 441 citations

Regulation of Adenylyl Cyclase-Coupled beta-Adrenergic Receptors

1988 • 389 citations

Stimulation of phospholipase A2 activity in bovine rod outer segments by the beta gamma subunits of transducin and its inhibition by the alpha subunit.

1987 • 344 citations

Role of phosphorylation in desensitization of the β-adrenoceptor

1990 • 300 citations

Light-dependent phosphorylation of rhodopsin. Purification and properties of rhodopsin kinase.

1978 • 291 citations

Reconstitutively active G protein-coupled receptors purified from baculovirus-infected insect cells.

1991 • 283 citations

Purification and characterization of the beta-adrenergic receptor kinase.

1987 • 241 citations

The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution, activity, and properties of the 35,000-dalton (beta) subunit.

1983 • 237 citations

Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase

1986 • 205 citations

The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis.

1987 • 199 citations

Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles.

1986 • 199 citations

Inactivation of photoexcited rhodopsin in retinal rods: the roles of rhodopsin kinase and 48-kDa protein (arrestin)

1988 • 185 citations

Mechanisms of muscarinic receptor action on Go in reconstituted phospholipid vesicles

1989 • 180 citations

Chapter 5 Interactions between photoexcited rhodopsin and light-activated enzymes in rods

1984 • 174 citations

Rhodopsin-enhanced GTPase activity of the inhibitory GTP-binding protein of adenylate cyclase.

1984 • 166 citations

Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase.

1987 • 156 citations

Purification of the muscarinic acetylcholine receptor from porcine brain.

1985 • 142 citations

Phosphorylation of chick heart muscarinic cholinergic receptors by the .beta.-adrenergic receptor kinase

1989 • 133 citations

Rhodopsin kinase: substrate specificity and factors that influence activity

1988 • 125 citations

Chapter 1 Rhodopsin chemistry, structure and topography

1982 • 115 citations

Rhodopsin kinase prepared from bovine rod disk membranes quenches light activation of cGMP phosphodiesterase in a reconstituted system

1986 • 102 citations

Correlation of agonist-induced phosphorylation of chick heart muscarinic receptors with receptor desensitization.

1987 • 98 citations

Current Aspects of the Neurosciences

1990 • 94 citations

Inhibition of the β-Adrenergic Receptor Kinase by Polyanions

1989 • 83 citations

Dual regulation by G proteins of agonist‐dependent phosphorylation of muscarinic acetylcholine receptors

1990 • 80 citations

Characterization of rhodopsin kinase purified from bovine rod outer segments.

1990 • 71 citations

Interaction between photoexcited rhodopsin and peripheral enzymes in frog retinal rods

1983 • 65 citations

Transducin inhibition of light-dependent rhodopsin phosphorylation: evidence for beta gamma subunit interaction with rhodopsin.

1988 • 61 citations

Structure and Regulation of Muscarinic Receptors

1989 • 59 citations

Cerebral muscarinic acetylcholine receptors interact with three kinds of GTP-binding proteins in a reconstitution system of purified components.

1989 • 41 citations

<b>AGONIST-DEPENDENT PHOSPHORYLATION OF CEREBRAL AND ATRIAL MUSCARINIC RECEPTORS: BLOCKADE OF THE PHOSPHORYLATION BY GTP-BINDING REGULATORY PROTEINS AND ITS REVERSAL BY GUANINE </b><b>NUCLEOTIDES </b>

1989 • 31 citations

Muscarinic Cholinergic Receptors and their Interactions with Drugs

1989 • 30 citations

Current Aspects of the Neurosciences

1990 • 17 citations

<b>COMPARISON BETWEEN PURIFIED CEREBRAL AND ATRIAL MUSCARINIC ACETYLCHOLINE RECEPTORS: PIRENZEPINE BINDING AND THE EFFECT OF SULFHYDRYL </b><b>REAGENTS </b>

1989 • 12 citations