Role of acidic amino acids in peptide substrates of the .beta.-adrenergic receptor kinase and rhodopsin kinase

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Molecular weight analysis of oligopeptides by electrophoresis in polyacrylamide gel with sodium dodecyl sulfate

1971 • 1,736 citations

Turning off the signal: desensitization of β‐adrenergic receptor function

1990 • 1,241 citations

[42] Detection and quantification of phosphotyrosine in proteins

1983 • 1,184 citations

β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function

1990 • 1,162 citations

Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α ₂ -Adrenergic Receptor

1987 • 792 citations

Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments.

1986 • 781 citations

Regulation of transmembrane signaling by receptor phosphorylation

1987 • 678 citations

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.

1986 • 650 citations

Structural basis of β‐adrenergic receptor function

1989 • 480 citations

Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein).

1987 • 478 citations

Adrenergic receptors. Models for the study of receptors coupled to guanine nucleotide regulatory proteins.

1988 • 455 citations

β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family

1989 • 451 citations

Light-dependent phosphorylation of rhodopsin: number of phosphorylation sites

1982 • 441 citations

Substrate specificity determinants for casein kinase II as deduced from studies with synthetic peptides.

1987 • 431 citations

Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization

1988 • 429 citations

Phosphorylation Sites on Two Domains of the β2-Adrenergic Receptor Are Involved in Distinct Pathways of Receptor Desensitization

1989 • 415 citations

Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors.

1990 • 393 citations

Photolyzed rhodopsin catalyzes the exchange of GTP for bound GDP in retinal rod outer segments.

1980 • 391 citations

Regulation of Adenylyl Cyclase-Coupled beta-Adrenergic Receptors

1988 • 389 citations

Adenosine cyclic 3',5'-monophosphate dependent protein kinase: kinetic mechanism for the bovine skeletal muscle catalytic subunit

1982 • 380 citations

Light‐induced binding of 48‐kDa protein to photoreceptor membranes is highly enhanced by phosphorylation of rhodopsin

1984 • 358 citations

Purification and characterization of the gamma regulatory subunit of the cyclic GMP phosphodiesterase from retinal rod outer segments.

1982 • 336 citations

Molecular biology of the visual pigments

1986 • 335 citations

Structure of the Adrenergic and Related Receptors

1989 • 300 citations

Light-dependent phosphorylation of rhodopsin. Purification and properties of rhodopsin kinase.

1978 • 291 citations

Purification and characterization of the beta-adrenergic receptor kinase.

1987 • 241 citations

Regulation of adrenergic receptor function by phosphorylation. II. Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase.

1987 • 235 citations

[6] Catalytic subunit of cAMP-dependent protein kinase

1983 • 211 citations

Mammalian .beta.2-adrenergic receptor: purification and characterization

1984 • 207 citations

Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase

1986 • 205 citations

A synthetic peptide substrate specific for casein kinase II.

1985 • 202 citations

The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis.

1987 • 199 citations

Site specificity of casein kinase‐2 (TS) from rat liver cytosol

1986 • 193 citations

Phosphorylation of rhodopsin and quenching of cyclic GMP phosphodiesterase activation by ATP at weak bleaches.

1983 • 165 citations

Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase.

1987 • 156 citations

Mechanism of ATP quench of phosphodiesterase activation in rod disc membranes.

1983 • 144 citations

The carboxyl terminus of the hamster β-adrenergic receptor expressed in mouse L cells is not required for receptor sequestration

1987 • 142 citations

Synthetic peptides including acidic clusters as substrates and inhibitors of rat liver casein kinase TS (type-2).

1984 • 137 citations

Phosphorylation of chick heart muscarinic cholinergic receptors by the .beta.-adrenergic receptor kinase

1989 • 133 citations

Isolation and characterization of somatostatin from pigeon pancreas.

1979 • 126 citations

Rhodopsin kinase: substrate specificity and factors that influence activity

1988 • 125 citations

A novel catecholamine-activated adenosine cyclic 3',5'-phosphate independent pathway for .beta.-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous desensitization of adenylate cyclase

1986 • 125 citations

Deactivation of Photoactivated Rhodopsin by Rhodopsin-Kinase and Arrestin

1987 • 120 citations

Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors.

1989 • 117 citations

Adenylate cyclase coupling proteins are not essential for agonist-specific desensitization of lymphoma cells.

1981 • 96 citations

Phosphorylation of ovine rhodopsin. Identification of the phosphorylated sites

1984 • 95 citations

Inhibition of the β-Adrenergic Receptor Kinase by Polyanions

1989 • 83 citations

Substrate recognition determinants for rhodopsin kinase: studies with synthetic peptides, polyanions, and polycations

1989 • 80 citations

Selective inhibition of a cyclic nucleotide‐independent protein kinase (G‐type casein kinase) by naturally occurring glycosaminoglycans

1980 • 75 citations

Characterization of rhodopsin kinase purified from bovine rod outer segments.

1990 • 71 citations

Synthetic peptides of the hamster beta 2‐adrenoceptor as substrates and inhibitors of the beta‐adrenoceptor kinase.

1990 • 60 citations

Activation of rod outer segment phosphodiesterase by enzymatically altered rhodopsin: A regulatory role for the carboxyl terminus of rhodopsin

1984 • 29 citations