The injured cell: the role of the dendritic cell system as a sentinel receptor pathway

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

1984 • 3,530 citations

T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

1984 • 2,441 citations

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.

1994 • 1,722 citations

GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells

1992 • 1,608 citations

The immune system evolved to discriminate infectious nonself from noninfectious self

1992 • 1,324 citations

The major human rhinovirus receptor is ICAM-1

1989 • 1,134 citations

Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis

1990 • 871 citations

Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population

1993 • 673 citations

Migration and maturation of Langerhans cells in skin transplants and explants.

1990 • 663 citations

Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies.

1987 • 592 citations

Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection.

1990 • 561 citations

Immunobiology of Tissue Transplantation: A Return to the Passenger Leukocyte Concept

1983 • 524 citations

Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo.

1993 • 487 citations

Phagocytosis of antigens by Langerhans cells in vitro.

1993 • 474 citations

Identification of proliferating dendritic cell precursors in mouse blood.

1992 • 445 citations

Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow.

1993 • 428 citations

Effect of low concentrations of ozone on inhaled allergen responses in asthmatic subjects

1991 • 413 citations

Rapid dendritic cell recruitment is a hallmark of the acute inflammatory response at mucosal surfaces.

1994 • 395 citations

B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation.

1994 • 367 citations

Diesel-exhaust particulates inoculated by the intranasal route have an adjuvant activity for IgE production in mice

1987 • 320 citations

Studies on the density, distribution, and surface phenotype of intraepithelial class II major histocompatibility complex antigen (Ia)-bearing dendritic cells (DC) in the conducting airways.

1991 • 316 citations

MHC class II antigen-bearing dendritic cells in pulmonary tissues of the rat. Regulation of antigen presentation activity by endogenous macrophage populations.

1988 • 285 citations

Current Status of Immunological Adjuvants

1986 • 283 citations

Primary stimulation by dendritic cells induces antiviral proliferative and cytotoxic T cell responses in vitro.

1989 • 260 citations

Immunologic properties of purified epidermal Langerhans cells. Distinct requirements for stimulation of unprimed and sensitized T lymphocytes.

1986 • 238 citations

Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells.

1987 • 237 citations

Interleukin 1 enhances T-dependent immune responses by amplifying the function of dendritic cells.

1987 • 215 citations

Cells that present both specific ligand and costimulatory activity are the most efficient inducers of clonal expansion of normal CD4 T cells.

1992 • 214 citations

PHAGOCYTOSIS OF THE ANTIGEN, A CRUCIAL STEP IN THE INDUCTION OF THE PRIMARY RESPONSE

1965 • 211 citations

Characterization of sheep afferent lymph dendritic cells and their role in antigen carriage.

1989 • 196 citations

Development of the airway intraepithelial dendritic cell network in the rat from class II major histocompatibility (Ia)-negative precursors: differential regulation of Ia expression at different levels of the respiratory tract.

1994 • 190 citations

Isolation and characterization of dendritic cells from mouse heart and kidney.

1994 • 179 citations

Nitric oxide involvement in tumor-induced immunosuppression.

1994 • 171 citations

CD4+ blood dendritic cells are potent producers of IFN-alpha in response to in vitro HIV-1 infection.

1994 • 152 citations

Nitric oxide produced during murine listeriosis is protective

1994 • 148 citations

Microbial induction of co-stimulatory activity for CD4 T-cell growth

1991 • 130 citations

Tolerance to a Protein Antigen in Adult Mice and the Effect of Nonspecific Factors

1963 • 126 citations

Macrophage-derived nitric oxide is involved in the depressed concanavalin A responsiveness of splenic lymphocytes from rats administered morphine in vivo.

1994 • 97 citations

The epidemiology of the postpericardiotomy syndrome: A common complication of cardiac surgery

1988 • 94 citations

Induction of primary, antiviral cytotoxic, and proliferative responses with antigens administered via dendritic cells

1993 • 86 citations

Human tonsillar dendritic cell‐induced T cell responses: analysis of molecular mechanisms using monoclonal antibodies

1989 • 79 citations

Characterization of the tissue macrophage and the interstitial dendritic cell as distinct leukocytes normally resident in the connective tissue of rat heart.

1990 • 77 citations

Susceptibility or resistance to lysis by alloreactive natural killer cells is governed by a gene in the human major histocompatibility complex between BF and HLA-B.

1990 • 65 citations

Effect of thyroid hormones and other iodinated compounds on the transition of monocytes into veiled/dendritic cells: role of granulocyte-macrophage colony-stimulating factor, tumour-necrosis factor-α and interleukin-6

1994 • 58 citations

In vivo modulation of CD1 and MHC class II expression by sheep afferent lymph dendritic cells. Comparison of primary and secondary immune responses.

1989 • 55 citations

Macrophage factors which enhance the mixed leukocyte reaction initiated by dendritic cells.

1989 • 47 citations

Role of dendritic cells in the regulation of class I restricted cytotoxic T lymphocyte responses.

1988 • 31 citations

Human natural killer (NK) alloreactivity and its association with the major histocompatibility complex: ancestral haplotypes encode particular NK-defined haplotypes.

1993 • 21 citations

Role of Langerhans cells and other dendritic cells in viral diseases

1993 • 19 citations

Immunosuppression as a physiological homeostatic mechanism

1984 • 11 citations

Conditioned Medium from Activated Rat Macrophages and the Recombinant Factors, IL-1β and GM-CSF, Enhance the Accessory Activity of Dendritic Cells

1990 • 11 citations

Cancer of the cervix: prospects for immunological control.

1991 • 11 citations

Sensitization of Allo-Specific T Lymphocytes in vivo: Role of Antigen-Presenting Cells

1992 • 3 citations