Biology of LPA in health and disease

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

1999 • 1,484 citations

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

1996 • 1,473 citations

The emerging role of lysophosphatidic acid in cancer

2003 • 1,086 citations

Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

2002 • 908 citations

Identification of Human Plasma Lysophospholipase D, a Lysophosphatidic Acid-producing Enzyme, as Autotaxin, a Multifunctional Phosphodiesterase

2002 • 723 citations

Signal characteristics of G protein-transactivated EGF receptor

1997 • 669 citations

Lysophosphatidic Acid as a Potential Biomarker for Ovarian and Other Gynecologic Cancers

1998 • 642 citations

Identification of p2y9/GPR23 as a Novel G Protein-coupled Receptor for Lysophosphatidic Acid, Structurally Distant from the Edg Family

2003 • 553 citations

Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist

2002 • 545 citations

Lysophospholipids--Receptor Revelations

2001 • 539 citations

Requirement for the lp _A1 lysophosphatidic acid receptor gene in normal suckling behavior

2000 • 468 citations

Role of the Sphingosine-1-Phosphate Receptor EDG-1 in PDGF-Induced Cell Motility

2001 • 421 citations

Bioactive Lysophospholipids and Their G Protein-Coupled Receptors

1999 • 412 citations

Lysophosphatidic Acid Receptors

2000 • 404 citations

Lysophosphatidates bound to serum albumin activate membrane currents in Xenopus oocytes and neurite retraction in PC12 pheochromocytoma cells.

1992 • 355 citations

Characterization of an ovarian cancer activating factor in ascites from ovarian cancer patients.

1995 • 325 citations

P2-Purinergic Receptors: Subtype-Associated Signaling Responses and Structure

1995 • 323 citations

Lysophospholipid Receptors

2001 • 319 citations

Lysophospholipids activate ovarian and breast cancer cells

1995 • 289 citations

Lysophosphatidic Acid and Autotaxin Stimulate Cell Motility of Neoplastic and Non-neoplastic Cells through LPA1

2004 • 275 citations

The G-protein G13 but Not G12 Mediates Signaling from Lysophosphatidic Acid Receptor via Epidermal Growth Factor Receptor to Rho

1998 • 265 citations

Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding

2003 • 249 citations

Lysophospholipid Growth Factors in the Initiation, Progression, Metastases, and Management of Ovarian Cancer

2000 • 243 citations

Lysophosphatidic acid promotes matrix metalloproteinase (MMP) activation and MMP-dependent invasion in ovarian cancer cells.

2001 • 241 citations

Electrospray Ionization Mass Spectrometry Analysis of Lysophospholipids in Human Ascitic Fluids: Comparison of the Lysophospholipid Contents in Malignant vs Nonmalignant Ascitic Fluids

2001 • 234 citations

Lysophospholipid receptor nomenclature

2002 • 225 citations

Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1.

2003 • 214 citations

Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction

2002 • 209 citations

Molecular Cloning and Characterization of a Lysophosphatidic Acid Receptor, Edg-7, Expressed in Prostate

2000 • 206 citations

Lysophosphatidic Acid (LPA) in Malignant Ascites Stimulates Motility of Human Pancreatic Cancer Cells through LPA1

2004 • 176 citations

Constitutive and lysophosphatidic acid (LPA)-induced LPA production: role of phospholipase D and phospholipase A2.

2000 • 172 citations

Lysophosphatidic Acid Increases Tight Junction Permeability in Cultured Brain Endothelial Cells

1997 • 172 citations

Lysophosphatidic acid as a phospholipid mediator: pathways of synthesis

1997 • 169 citations

Phosphatidic and lysophosphatidic acid production in phospholipase C-and thrombin-treated platelets. possible involvement of a platelet lipase

1978 • 166 citations

Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer.

1999 • 166 citations

Effects of synthetic and natural lysophosphatidic acids on the arterial blood pressure of different animal species

1978 • 164 citations

Release of cAMP Gating by the α6β4 Integrin Stimulates Lamellae Formation and the Chemotactic Migration of Invasive Carcinoma Cells

1998 • 156 citations

Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells

1998 • 154 citations

Tethering of the Platelet-derived Growth Factor β Receptor to G-protein-coupled Receptors

2001 • 153 citations

Lysophosphatidic acid induces urokinase secretion by ovarian cancer cells.

1999 • 147 citations

Protein Kinase A Regulates Rac and Is Required for the Growth Factor-stimulated Migration of Carcinoma Cells

2001 • 143 citations

The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer.

2003 • 142 citations

Lysophosphatidic Acid-induced Mitogenesis Is Regulated by Lipid Phosphate Phosphatases and Is Edg-receptor Independent

2001 • 136 citations

Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate

1998 • 132 citations

Sphingosine 1-Phosphate and Platelet-derived Growth Factor (PDGF) Act via PDGFβ Receptor-Sphingosine 1-Phosphate Receptor Complexes in Airway Smooth Muscle Cells

2003 • 126 citations

Phospholipid content, composition and biosynthesis during fetal lung development in the rabbit

1976 • 122 citations

Lipid phosphate phosphatases regulate signal transduction through glycerolipids and sphingolipids

2002 • 119 citations

Modulation of intestinal epithelial wound healing in vitro and in vivo by lysophosphatidic acid

1999 • 119 citations

Lysophospholipids Increase Interleukin-8 Expression in Ovarian Cancer Cells

2001 • 116 citations

Phorbol 12-Myristate 13-Acetate Stimulates Lysophosphatidic Acid Secretion from Ovarian and Cervical Cancer Cells but Not from Breast or Leukemia Cells

1998 • 113 citations

Effect of Insulin on Cell Cycle Progression in MCF-7 Breast Cancer Cells

2001 • 109 citations

Evidence for preferential adhesion of ovarian epithelial carcinoma cells to type I collagen mediated by the αA2β1 integrin

1996 • 108 citations

In vivo roles of lysophospholipid receptors revealed by gene targeting studies in mice

2002 • 108 citations

Role for 18:1 Lysophosphatidic Acid as an Autocrine Mediator in Prostate Cancer Cells

2002 • 108 citations

Akt Activation Induced by Lysophosphatidic Acid and Sphingosine-1-phosphate Requires Both Mitogen-Activated Protein Kinase Kinase and p38 Mitogen-Activated Protein Kinase and Is Cell-Line Specific

2002 • 107 citations

Occurrence of lysophosphatidic acid and its alkyl ether-linked analog in rat brain and comparison of their biological activities toward cultured neural cells

1999 • 98 citations

Lysophosphatidic Acid Induces Necrosis and Apoptosis in Hippocampal Neurons

1998 • 98 citations

Lysophosphatidic acid‐regulated mitogenic ERK signaling in androgen‐insensitive prostate cancer PC‐3 cells

2002 • 94 citations

Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer.

2003 • 93 citations

Dual mechanisms for lysophospholipid induction of proliferation of human breast carcinoma cells.

1999 • 92 citations

TRIP6 Enhances Lysophosphatidic Acid-induced Cell Migration by Interacting with the Lysophosphatidic Acid 2 Receptor

2004 • 89 citations

Human platelet aggregation induced by 1-alkyl-lysophosphatidic acid and its analogs: A new group of phospholipid mediators?

1982 • 89 citations

Lysophosphatidic acid induces a pertussis toxin-sensitive Ca(2+)-activated Cl- current in Xenopus laevis oocytes

1992 • 84 citations

Mitogenic action of LPA in prostate

2002 • 83 citations

Lysophospholipid Receptors: Implications for Neural Signaling

1999 • 83 citations

A novel laminin‐induced lysophosphatidic acid autocrine loop in the migration of ovarian cancer cells

2003 • 81 citations

An Epidermal Growth Factor Receptor/Gab1 Signaling Pathway Is Required for Activation of Phosphoinositide 3-Kinase by Lysophosphatidic Acid

1999 • 81 citations

Peptide and lipid growth factors decrease cis-diamminedichloroplatinum-induced cell death in human ovarian cancer cells.

1996 • 75 citations

S1P ₃ ‐mediated Akt activation and crosstalk with platelet‐derived growth factor receptor (PDGFR)

2003 • 75 citations

Lysophospholipids and the cardiovascular system

2002 • 74 citations

Tyrosine kinase-activating growth factors potentiate thrombin- and AIF4- -induced phosphoinositide breakdown in hamster fibroblasts. Evidence for positive cross-talk between the two mitogenic signaling pathways.

1988 • 73 citations

Selective blockade of lysophosphatidic acid LPA₃receptors reduces murine renal ischemia-reperfusion injury

2003 • 73 citations

Unfolding the Pathophysiological Role of Bioactive Lysophospholipids

2003 • 73 citations

Life on the edg

1999 • 72 citations

Ovarian surface epithelium: family history and early events in ovarian cancer.

2003 • 67 citations

Migration of Vascular Smooth Muscle Cells Induced by Sphingosine 1-Phosphate and Related Lipids: Potential Role in the Angiogenic Response

2002 • 65 citations

Lysophosphatidic acid stimulates phospholipase D activity and cell proliferation in PC-3 human prostate cancer cells

1998 • 63 citations

Enhancement of the Migration of Metastatic Human Breast Cancer Cells by Phosphatidic Acid

2000 • 57 citations

Synergism among Lysophosphatidic Acid, β1A Integrins, and Epidermal Growth Factor or Platelet-derived Growth Factor in Mediation of Cell Migration

1999 • 55 citations

Lysophosphatidic acid in airway function and disease

2002 • 55 citations

GUANOSINE PHOSPHATE BINDING PROTEIN COUPLED RECEPTORS IN PROSTATE CANCER: A REVIEW

2002 • 49 citations

Lysophosphatidic Acid Stimulates Intestinal Restitution via Cytoskeletal Activation and Remodeling

2000 • 47 citations

Sphingosine 1‐Phosphate Activates Erk‐1/‐2 by Transactivating Epidermal Growth Factor Receptor in Rat‐2 Cells

2000 • 46 citations

Induction of macrophage migration inhibitory factor by lysophosphatidic acid: Relevance to tumor growth and angiogenesis

2003 • 46 citations

Lysophosphatidic acid stimulates nuclear and cytoplasmic maturation of golden hamster immature oocytes in vitro via cumulus cells

2002 • 44 citations

Lysophosphatidic Acid and Its Role in Reproduction

2002 • 44 citations

Effects of Lysophosphatidic Acid on Proliferation and Cytosolic Ca++ of Human Adult Vascular Smooth Muscle Cells in Culture

1999 • 43 citations

The platelet-derived-growth-factor receptor, not the epidermal-growth-factor receptor, is used by lysophosphatidic acid to activate p42/44 mitogen-activated protein kinase and to induce prostaglandin G/H synthase-2 in mesangial cells

2000 • 42 citations

Endothelial Differentiation Gene Receptors in Pancreatic Islets and INS-1 Cells

2003 • 36 citations

Biochemical regulation of breast cancer cell expression of S1P₂ (Edg‐5) and S1P₃ (Edg‐3) G protein‐coupled receptors for sphingosine 1‐phosphate

2002 • 32 citations

Lisofylline and Lysophospholipids Ameliorate Experimental Colitis in Rats

2002 • 32 citations

G Protein-coupled Receptor-induced Sensitization of Phospholipase C Stimulation by Receptor Tyrosine Kinases

2000 • 30 citations

Membrane sidedness of biosynthetic pathways involved in the production of lysophosphatidic acid

1999 • 30 citations

Preservation of living tissue in the frozen state

1961 • 26 citations

Lysophosphatidic Acid: A Novel Phospholipid with Hormone- and Growth Factor-like Activities

1992 • 26 citations

Unfolding the Pathophysiological Role of Bioactive Lysophospholipids

2003 • 26 citations

Specific Keynote: Molecular Therapeutics in Ovarian Cancer

2003 • 24 citations

Inhibition of lysophosphatidic acid-induced RhoA activation and tumor cell invasion by 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors

2003 • 22 citations

Lysophosphatidic acid augments fibroblast-mediated contraction of released collagen gels

2002 • 21 citations

EDG receptors and hepatic pathophysiology of LPA and S1P: EDG-ology of liver injury

2002 • 19 citations

Lysophosphatidic acid stimulates glucose transport in Xenopus oocytes via a phosphatidylinositol 3′-kinase with distinct properties

1996 • 18 citations

Identification of an EDG7 Variant, HOFNH30, a G-Protein-Coupled Receptor for Lysophosphatidic Acid

2000 • 18 citations

Growth Factor‐Like Action of Lysophosphatidic Acid: Mitogenic Signalling Mediated by G Proteins

2007 • 18 citations

Analysis of the Proliferative Response to Lysophosphatidic Acid in Primary Cultures of Mammary Epithelium: Differences between Normal and Tumor Cells

1995 • 17 citations

Lysophosphatidic acid induces glycodelin gene expression in cancer cells

2002 • 16 citations

Regulation of Expression of EDG Family Receptors in Human Prostate Cancer Cell Lines

2000 • 16 citations

Crosstalk between G protein-coupled receptors and tyrosine kinase signaling: Src take centre stage.

2000 • 15 citations

Effects of lysophosphatidic acids and their structural analogs on arterial blood pressure of cats.

1985 • 14 citations

Signaling Responses to Alkyllysophosphatidic Acid: The Activation of Phospholipases A2and C and Protein Tyrosine Phosphorylation in Human Platelets

1996 • 12 citations

The platelet-derived-growth-factor receptor, not the epidermal-growth-factor receptor, is used by lysophosphatidic acid to activate p42/44 mitogen-activated protein kinase and to induce prostaglandin G/H synthase-2 in mesangial cells

2000 • 10 citations

Man-made mineral fibers induce apoptosis of human peripheral blood mononuclear cells similarly to chrysotile B.

1999 • 8 citations

Drug and anesthetic effects on membrane structure and function (Advances in membrane fluidity, Vol. 5)

1991 • 4 citations

Alkylacetylglycerophosphocholine effects on the metabolism of phospholipids in rabbit platelets: Effects of extracellular Ca2+ and prostacyclin

1986 • 4 citations

RESISTANCE TO 1-BETA-D-ARABINOFURANOSYLCYTOSINE AND HYPERSENSITIVITY TO BLEOMYCIN IN ATAXIA-TELANGIECTASIA B-LYMPHOBLASTOID CELL-LINES

1994 • 2 citations