Alpha1-adrenergic receptors: new insights and directions.

Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

2000 • 5,539 citations

Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human

1999 • 2,692 citations

International Union of Pharmacology. X. Recommendation for nomenclature of alpha 1-adrenoceptors: consensus update.

1995 • 694 citations

Alpha 1-adrenergic receptor subtypes, inositol phosphates, and sources of cell Ca2+.

1988 • 566 citations

α ₁ -Adrenergic Receptor Subtypes

1996 • 509 citations

Structural basis of β‐adrenergic receptor function

1989 • 480 citations

Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy.

1994 • 369 citations

Subtype Specific Regulation of Human Vascular α ₁ -Adrenergic Receptors by Vessel Bed and Age

1999 • 291 citations

Activation of phospholipase C by alpha 1-adrenergic receptors is mediated by the alpha subunits of Gq family.

1992 • 285 citations

Decreased blood pressure response in mice deficient of the α _1b -adrenergic receptor

1997 • 282 citations

5-HT2A receptor or α1-adrenoceptor activation induces excitatory postsynaptic currents in layer V pyramidal cells of the medial prefrontal cortex

1999 • 218 citations

Role of Clathrin-mediated Endocytosis in Agonist-induced Down-regulation of the β2-Adrenergic Receptor

1998 • 211 citations

Actions of norepinephrine in the cerebral cortex and thalamus: implications for function of the central noradrenergic system

1991 • 204 citations

Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor.

1996 • 190 citations

Prazosin modulates the firing pattern of dopamine neurons in rat ventral tegmental area

1993 • 188 citations

Subtype-Specific Intracellular Trafficking of α₂-Adrenergic Receptors

1997 • 181 citations

The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle.

1995 • 181 citations

Transgenic Mice with Cardiac Overexpression of α1B-Adrenergic Receptors

1997 • 151 citations

Coupling of expressed alpha 1B- and alpha 1D-adrenergic receptor to multiple signaling pathways is both G protein and cell type specific.

1993 • 151 citations

α1-Adrenoceptors: function and phosphorylation

2000 • 136 citations

Activation of the α1b-Adrenergic Receptor Is Initiated by Disruption of an Interhelical Salt Bridge Constraint

1996 • 133 citations

Overexpression of the α1B-adrenergic receptor causes apoptotic neurodegeneration: Multiple system atrophy

2000 • 125 citations

Characterization of the Phosphorylation Sites Involved in G Protein-coupled Receptor Kinase- and Protein Kinase C-mediated Desensitization of the α1B-Adrenergic Receptor

1997 • 123 citations

Coupling efficiencies of human alpha 1-adrenergic receptor subtypes: titration of receptor density and responsiveness with inducible and repressible expression vectors.

1996 • 122 citations

Distribution of ?1A adrenergic receptor m RNA in the rat brain visualized by in situ hybridization

1997 • 120 citations

Neuron–Glia Signaling via α₁Adrenoceptor-Mediated Ca²⁺Release in Bergmann Glial CellsIn Situ

1999 • 116 citations

Expression of multiple alpha1-adrenoceptors on vascular smooth muscle: correlation with the regulation of contraction.

1999 • 109 citations

Subtype-Specific Differences in Subcellular Localization of α₁-Adrenoceptors: Chlorethylclonidine Preferentially Alkylates the Accessible Cell Surface α₁-Adrenoceptors Irrespective of the Subtype

1997 • 106 citations

α_1D-Adrenergic Receptors and Mitogen-Activated Protein Kinase Mediate Increased Protein Synthesis by Arterial Smooth Muscle

1997 • 104 citations

Noradrenergic potentiation of excitatory transmitter action in cerebrocortical slices: evidence for mediation by an α1 receptor-linked second messenger pathway

1991 • 103 citations

The Unique Nature of the Serine Interactions for α1-Adrenergic Receptor Agonist Binding and Activation

1996 • 103 citations

Hypotension, Autonomic Failure, and Cardiac Hypertrophy in Transgenic Mice Overexpressing the α1B-Adrenergic Receptor

2001 • 97 citations

Regulation of the Cellular Localization and Signaling Properties of the α_1B- and α_1D-Adrenoceptors by Agonists and Inverse Agonists

2000 • 95 citations

Agonist Regulation of α1B-Adrenergic Receptor Subcellular Distribution and Function

1995 • 95 citations

Identification of Critical Determinants of α1-Adrenergic Receptor Subtype Selective Agonist Binding

1995 • 92 citations

Identification of critical extracellular loop residues involved in alpha 1-adrenergic receptor subtype-selective antagonist binding.

1996 • 90 citations

Central α1-adrenoceptors

1999 • 87 citations

Immunocytochemical localization of the alpha-1B adrenergic receptor and the contribution of this and the other subtypes to vascular smooth muscle contraction: analysis with selective ligands and antisense oligonucleotides.

1997 • 87 citations

Overexpression of α_1B-adrenergic receptor induces left ventricular dysfunction in the absence of hypertrophy

1998 • 85 citations

Pharmacological characterization of an α_1A‐adrenoceptor mediating contractile responses to noradrenaline in isolated caudal artery of rat

1997 • 82 citations

Quantitative imaging in live human cells reveals intracellular alpha(1)-adrenoceptor ligand-binding sites.

2000 • 73 citations

Constitutive Activation of the δ Opioid Receptor by Mutations in Transmembrane Domains III and VII

1999 • 73 citations

Human adrenoceptor polymorphisms: evolving recognition of clinical importance

1999 • 73 citations

Structure activity relationships of a series of buspirone analogs at alpha-1 adrenoceptors: further evidence that rat aorta alpha-1 adrenoceptors are of the alpha-1D-subtype.

1996 • 73 citations

Cardiovascular α<sub>1</sub>-adrenoceptor subtypes: functions and signaling

2000 • 61 citations

Norepinephrine- and Phorbol Ester-induced Phosphorylation of α1a-Adrenergic Receptors

2000 • 60 citations

Differential Activation of Mitogen‐Activated Protein Kinase Pathways in PC12 Cells by Closely Related α₁‐Adrenergic Receptor Subtypes

1999 • 58 citations

Recent advances in the molecular pharmacology of the α1-adrenergic receptors

1996 • 56 citations

Phe-308 and Phe-312 in Transmembrane Domain 7 Are Major Sites of α1-Adrenergic Receptor Antagonist Binding

2001 • 55 citations

Modulation of basal intracellular calcium by inverse agonists and phorbol myristate acetate in rat‐1 fibroblasts stably expressing α_1d‐adrenoceptors

1999 • 54 citations

Identification of Distinct Carboxyl-Terminal Domains Mediating Internalization and Down-Regulation of the Hamster α_1B- Adrenergic Receptor

2000 • 52 citations

Functional evidence of a constitutively active population of alpha(1D)-adrenoceptors in rat aorta.

2000 • 51 citations

Chimeric Receptor Analysis of the Ketanserin Binding Site in the Human 5-Hydroxytryptamine_1DReceptor: Importance of the Second Extracellular Loop and Fifth Transmembrane Domain in Antagonist Binding

1998 • 50 citations

alpha1-Adrenergic receptor stimulation of mitogenesis in human vascular smooth muscle cells: role of tyrosine protein kinases and calcium in activation of mitogen-activated protein kinase.

1999 • 48 citations

Phe310 in Transmembrane VI of the α1B-Adrenergic Receptor Is a Key Switch Residue Involved in Activation and Catecholamine Ring Aromatic Bonding

1999 • 47 citations

Phenylalanine in the Second Membrane-Spanning Domain of α_1A-Adrenergic Receptor Determines Subtype Selectivity of Dihydropyridine Antagonists

1996 • 45 citations

Characterization of α1-adrenoceptor subtypes in facilitation of rat spinal motoneuron activity

1997 • 41 citations

Differential regulation of human α1-adrenoceptor subtypes

1999 • 39 citations

The third extracellular loop of the human delta-opioid receptor determines the selectivity of delta-opioid agonists.

1996 • 38 citations

Alpha1-adrenoceptor-mediated excitation of substantia nigra pars reticulata neurons

2000 • 36 citations

Kinetics of alkylation of cloned rat α1-adrenoceptor subtypes by chloroethylclonidine

1998 • 28 citations

Pharmacological implications of cellular localization of α₁‐adrenoceptors in native smooth muscle cells

1999 • 22 citations

Novel Aromatic Residues in Transmembrane Domains IV and V Involved in Agonist Binding at α1a-Adrenergic Receptors

2000 • 21 citations

Differential Regulation of 46 and 54 kDa Jun N-Terminal Kinases and p38 Mitogen-Activated Protein Kinase by Human α1A-Adrenoceptors Expressed in Rat-1 Cells

1999 • 11 citations

Localizing the alpha-1 Adrenergic Receptor in the Central Nervous System

1987 • 6 citations