Multi-Modal Antigen Specific Therapy for Autoimmunity

Interleukin-10 and the Interleukin-10 Receptor

2001 • 6,422 citations

Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

1995 • 1,528 citations

Binding of immunogenic peptides to Ia histocompatibility molecules

1985 • 1,209 citations

The Biochemistry and Cell Biology of Antigen Processing and Presentation

1993 • 1,022 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression.

1993 • 862 citations

Dominance and Crypticity of T Cell Antigenic Determinants

1993 • 838 citations

Cytotoxic T cells recognize fragments of the influenza nucleoprotein

1985 • 669 citations

Peripheral Selection of the T Cell Repertoire

1991 • 666 citations

Partial T cell signaling: Altered phospho-? and lack of zap70 recruitment in APL-induced T cell anergy

1994 • 608 citations

Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

1993 • 595 citations

Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation.

1993 • 569 citations

Separation of IL-4 Production from Th Cell Proliferation by an Altered T Cell Receptor Ligand

1991 • 565 citations

T Cell Deletion in High Antigen Dose Therapy of Autoimmune Encephalomyelitis

1994 • 530 citations

Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis.

1995 • 522 citations

ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists

1995 • 510 citations

Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor

1992 • 501 citations

A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands

1993 • 414 citations

Interleukin‐10 inhibits B7 and intercellular adhesion molecule‐1 expression on human monocytes

1994 • 396 citations

Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice.

1989 • 372 citations

Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody.

1990 • 360 citations

Reversal of Proinflammatory Responses by Ligating the Macrophage Fcγ Receptor Type I

1998 • 330 citations

T cell receptor antagonists and partial agonists

1995 • 303 citations

Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells.

1993 • 266 citations

Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells.

1996 • 260 citations

Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen

1993 • 260 citations

Amelioration of Autoimmune Encephalomyelitis by Myelin Basic Protein Synthetic Peptide-Induced Anergy

1992 • 251 citations

Profound deletion of mature T cells in vivo by chronic exposure to exogenous superantigen.

1993 • 241 citations

Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling.

1993 • 238 citations

Molecules involved in T-cell costimulation

1993 • 237 citations

Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand

1995 • 236 citations

Induction of active and adoptive relapsing experimental autoimmune encephalomyelitis (EAE) using an encephalitogenic epitope of proteolipid protein

1992 • 231 citations

Multiple levels of peripheral tolerance

1993 • 216 citations

A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire.

1994 • 216 citations

Presentation of a Viral T Cell Epitope Expressed in the CDR3 Region of a Self Immunoglobulin Molecule

1993 • 123 citations

Studies of aggregated gamma-globulin. I. Sedimentation, electrophoretic and anticomplementary properties.

1960 • 119 citations

Molecular mechanisms underlying functional T-cell unresponsiveness

1995 • 115 citations

Modifications of peptide ligands enhancing T cell responsiveness imply large numbers of stimulatory ligands for autoreactive T cells.

1997 • 86 citations

Systemic antigen in the treatment of T-cell-mediated autoimmune diseases

1997 • 85 citations

Heteroclitic proliferative responses and changes in cytokine profile induced by altered peptides: Implications for autoimmunity

1998 • 80 citations

Effect of T-cell receptor antagonism on interaction between T cells and antigen-presenting cells and on T-cell signaling events.

1993 • 74 citations

Coupling of Peripheral Tolerance to Endogenous Interleukin 10 Promotes Effective Modulation of Myelin-Activated T Cells and Ameliorates Experimental Allergic Encephalomyelitis

2000 • 70 citations

Antagonism of superantigen-stimulated helper T-cell clones and hybridomas by altered peptide ligand.

1994 • 68 citations

Immune complex‐induced interleukin‐6, interleukin‐10 and prostaglandin secretion by human monocytes: a network of pro‐ and anti‐inflammatory cytokines dependent on the antigen: antibody ratio

1996 • 68 citations

Immune complexes are potent inhibitors of interleukin‐12 secretion by human monocytes

1997 • 65 citations

T-cell tolerance

1993 • 55 citations

Efficient loading of identical viral peptide onto class II molecules by antigenized immunoglobulin and influenza virus.

1993 • 44 citations

Presentation of a T Cell Receptor Antagonist Peptide by Immunoglobulins Ablates Activation of T Cells by a Synthetic Peptide or Proteins Requiring Endocytic Processing

1997 • 42 citations

Experimental Autoimmune Encephalomyelitis Induced with a Combination of Myelin Basic Protein and Myelin Oligodendrocyte Glycoprotein Is Ameliorated by Administration of a Single Myelin Basic Protein Peptide

1998 • 39 citations

Thermal properties of human IgG

1987 • 39 citations

Tolerance of CD8+ T cells developing in parent-->F1 chimeras prepared with supralethal irradiation: step-wise induction of tolerance in the intrathymic and extrathymic environments.

1993 • 32 citations

Anergy of antigen-specific T lymphocytes is a potent mechanism of intravenously induced tolerance.

1994 • 29 citations

TCR Agonist and Antagonist Exert In Vivo Cross-Regulation When Presented on Igs

1998 • 9 citations