Activation-dependent changes in soluble fibronectin binding and expression of β1 integrin activation epitopes in T cells: relationship to T cell adhesion and migration

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

1989 • 1,587 citations

Chemokines and the Arrest of Lymphocytes Rolling Under Flow Conditions

1998 • 1,013 citations

Lymphocyte interactions with endothelial cells

1992 • 689 citations

Regulated expression and binding of three VLA (β1) integrin receptors on T cells

1990 • 634 citations

A Synthetic Peptide from Fibronectin Inhibits Experimental Metastasis of Murine Melanoma Cells

1986 • 634 citations

Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin.

1992 • 542 citations

Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase

1995 • 520 citations

Suppression of Integrin Activation: A Novel Function of a Ras/Raf-Initiated MAP Kinase Pathway

1997 • 501 citations

Enhancement of LFA-1-mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes

1989 • 482 citations

Regulation of the fibronectin receptor affinity by divalent cations.

1988 • 441 citations

αLβ2 Integrin/LFA-1 Binding to ICAM-1 Induced by Cytohesin-1, a Cytoplasmic Regulatory Molecule

1996 • 439 citations

Integrin Activation by R-ras

1996 • 414 citations

Differential utilization of ICAM-1 and VCAM-1 during the adhesion and transendothelial migration of human T lymphocytes.

1991 • 388 citations

CD31 expressed on distinctive T cell subsets is a preferential amplifier of beta 1 integrin-mediated adhesion.

1992 • 383 citations

Dual role of the CD44 molecule in T cell adhesion and activation.

1989 • 335 citations

Activated Conformations of Very Late Activation Integrins Detected by a Group of Antibodies (HUTS) Specific for a Novel Regulatory Region(355-425) of the Common β1 Chain

1996 • 298 citations

Monoclonal Antibody 9EG7 Defines a Novel β1 Integrin Epitope Induced by Soluble Ligand and Manganese, but Inhibited by Calcium

1995 • 281 citations

Are changes in integrin affinity and conformation overemphasized?

1998 • 257 citations

Wortmannin and Its Structural Analogue Demethoxyviridin Inhibit Stimulated Phospholipase A2 Activity in Swiss 3T3 Cells

1995 • 252 citations

T cell adhesion to intercellular adhesion molecule-1 (ICAM-1) is controlled by cell spreading and the activation of integrin LFA-1.

1996 • 249 citations

Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells.

1995 • 237 citations

Sequential regulation of alpha 4 beta 1 and alpha 5 beta 1 integrin avidity by CC chemokines in monocytes: implications for transendothelial chemotaxis.

1996 • 220 citations

Crosslinking of the T cell-specific accessory molecules CD7 and CD28 modulates T cell adhesion.

1992 • 194 citations

The C–C Chemokine MCP-1 Differentially Modulates the Avidity of β1 and β2 Integrins on T Lymphocytes

1996 • 193 citations

Mutational Evidence for Control of Cell Adhesion Through Integrin Diffusion/Clustering, Independent of Ligand Binding

1997 • 179 citations

Steel factor and c-kit regulate cell-matrix adhesion

1994 • 178 citations

Stimulation of integrin-mediated adhesion of T lymphocytes and monocytes: two mechanisms with divergent biological consequences.

1994 • 149 citations

T cell receptor-dependent, antigen-specific stimulation of a murine T cell clone induces a transient, VLA protein-mediated binding to extracellular matrix.

1991 • 125 citations

Steel factor and c-kit regulate cell-matrix adhesion

1994 • 124 citations

Characterization of a Soluble Adrenal Phosphatidylinositol 4-Kinase Reveals Wortmannin Sensitivity of Type III Phosphatidylinositol Kinases

1996 • 119 citations

c-kit receptor signaling through its phosphatidylinositide-3'-kinase-binding site and protein kinase C: role in mast cell enhancement of degranulation, adhesion, and membrane ruffling.

1997 • 114 citations

Two integrin-binding peptides abrogate T cell-mediated immune responses in vivo.

1991 • 113 citations

A role for phosphatidylinositol 3-kinase in the regulation of beta 1 integrin activity by the CD2 antigen.

1995 • 111 citations

Receptor tyrosine kinase stimulates cell-matrix adhesion by phosphatidylinositol 3 kinase and phospholipase C-gamma 1 pathways

1995 • 108 citations

Lymphocyte adhesion can be regulated by cytoskeleton-associated, PMA-induced capping of surface receptors

1992 • 108 citations

A high affinity conformational state on VLA integrin heterodimers induced by an anti-beta 1 chain monoclonal antibody

1993 • 108 citations

CD28-mediated up-regulation of beta 1-integrin adhesion involves phosphatidylinositol 3-kinase.

1996 • 102 citations

Vascular Cell Adhesion Molecule (VCAM)-Ig Fusion Protein Defines Distinct Affinity States of the Very Late Antigen-4 (VLA-4) Receptor

1995 • 98 citations

Regulation of human CD44H and CD44E isoform binding to hyaluronan by phorbol myristate acetate and anti-CD44 monoclonal and polyclonal antibodies.

1993 • 86 citations

Critical Residues for Ligand Binding in an I Domain-like Structure of the Integrin β1 Subunit

1996 • 85 citations

STT4 Is an Essential Phosphatidylinositol 4-Kinase That Is a Target of Wortmannin in Saccharomyces cerevisiae

1997 • 80 citations

RANTES stimulation of T lymphocyte adhesion and activation: role for LFA‐1 and ICAM‐3

1997 • 78 citations

Very late antigen 4-dependent adhesion and costimulation of resting human T cells by the bacterial beta 1 integrin ligand invasin.

1993 • 69 citations

CD7-mediated regulation of integrin adhesiveness on human T cells involves tyrosine phosphorylation-dependent activation of phosphatidylinositol 3-kinase.

1997 • 63 citations

Differential activation-dependent regulation of integrin function in cultured human T-leukemic cell lines

1994 • 54 citations

Wortmannin, a phosphatidylinositol 3-kinase inhibitor, blocks antigen-mediated, but not CD3 monoclonal antibody-induced, activation of murine CD4+ T cells.

1997 • 53 citations

Regulation of Conformation and Ligand Binding Function of Integrin α5β1 by the β1 Cytoplasmic Domain

1996 • 49 citations

Identification of a Proline-Rich Sequence in the CD2 Cytoplasmic Domain Critical for Regulation of Integrin-Mediated Adhesion and Activation of Phosphoinositide 3-Kinase

1998 • 49 citations

Functional relevance during lymphocyte migration and cellular localization of activated β1 integrins

1997 • 44 citations

Vascular cell adhesion molecule-Ig fusion protein selectively targets activated alpha 4-integrin receptors in vivo. Inhibition of autoimmune diabetes in an adoptive transfer model in nonobese diabetic mice.

1995 • 35 citations

Binding of CD44 to Hyaluronic Acid Can Be Induced by Multiple Signals and Requires the CD44 Cytoplasmic Domain

1996 • 22 citations

Measurement of Cellular Adhesion Under Static Conditions

2000 • 14 citations

Differential activation-dependent regulation of integrin function in cultured human T-leukemic cell lines

1994 • 8 citations