Receptor tyrosine kinase stimulates cell-matrix adhesion by phosphatidylinositol 3 kinase and phospholipase C-gamma 1 pathways

Adhesion receptors of the immune system

1990 • 6,585 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

1989 • 1,587 citations

A safe packaging line for gene transfer: separating viral genes on two different plasmids

1988 • 1,118 citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1993 • 966 citations

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

1993 • 738 citations

SH2 and SH3 domains

1993 • 697 citations

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

1992 • 692 citations

Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1993 • 658 citations

Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins

1989 • 524 citations

Regulation of chemotaxis by the platelet-derived growth factor receptor-β

1994 • 441 citations

Effect of phorbol esters on protein kinase C-zeta.

1992 • 282 citations

Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells.

1995 • 237 citations

Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma.

1992 • 231 citations

The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp.

1993 • 214 citations

Stem cell factor induces mast cell adhesion to fibronectin.

1994 • 205 citations

Platelet-Derived Growth Factor (PDGF)-Dependent Association of Phospholipase C-γ with the PDGF Receptor Signaling Complex

1990 • 204 citations

Regulation of vascular integrins [published erratum appears in Blood 1994 Apr 1;83(7):2013]

1993 • 199 citations

Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor.

1993 • 189 citations

Steel factor and c-kit regulate cell-matrix adhesion

1994 • 178 citations

Steel factor and c-kit regulate cell-matrix adhesion

1994 • 124 citations

Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction.

1991 • 109 citations

Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types.

1993 • 100 citations

Activation of c-Src in cells bearing v-Crk and its suppression by Csk.

1992 • 99 citations

Activation of c-Src in Cells Bearing v-Crk and Its Suppression by Csk

1992 • 29 citations

Platelet-Derived Growth Factor Receptor Mediates Activation of Ras through Different Signaling Pathways in Different Cell Types

1993 • 12 citations

Tyrosine Mutations within the a Platelet-Derived Growth Factor Receptor Kinase Insert Domain Abrogate Receptor-Associated Phosphatidylinositol-3 Kinase Activity without Affecting Mitogenic or Chemotactic Signal Transduction

1991 • 10 citations