Gene transfer into hematopoietic cells

In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector

1996 • 4,854 citations

Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection.

1990 • 1,465 citations

Differentiation and proliferation of hematopoietic stem cells

1993 • 1,417 citations

A safe packaging line for gene transfer: separating viral genes on two different plasmids

1988 • 1,118 citations

Isolation of a candidate human hematopoietic stem-cell population.

1992 • 1,098 citations

Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain

1994 • 1,032 citations

Gene-marking to trace origin of relapse after autologous bone-marrow transplantation

1993 • 949 citations

Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges.

1988 • 908 citations

Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector

1996 • 902 citations

Developmental potential and dynamic behavior of hematopoietic stem cells

1986 • 888 citations

Gene Therapy in Peripheral Blood Lymphocytes and Bone Marrow for ADA ⁻ Immunodeficient Patients

1995 • 846 citations

Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy

1996 • 795 citations

Use of Adeno-Associated Virus as a General Transduction Vector for Mammalian Cells

1992 • 755 citations

Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors

1996 • 747 citations

Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/W mice

1985 • 663 citations

Recombinant adeno-associated virus for muscle directed gene therapy

1997 • 656 citations

Gene Therapy for Cancer: What Have We Done and Where Are We Going?

1997 • 635 citations

Engraftment of gene–modified umbilical cord blood cells in neonates with adenosine deaminase deficiency

1995 • 622 citations

Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters.

1994 • 586 citations

T–cell mediated rejection of gene–modified HIV–specific cytotoxic T lymphocytes in HIV–infected patients

1996 • 581 citations

Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells

1996 • 565 citations

Helper virus induced T cell lymphoma in nonhuman primates after retroviral mediated gene transfer.

1992 • 544 citations

Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis

1996 • 542 citations

Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse

1984 • 527 citations

Genetic marking shows that Ph+ cells present in autologous transplants of chronic myelogenous leukemia (CML) contribute to relapse after autologous bone marrow in CML

1994 • 502 citations

Retrovirally marked CD34-enriched peripheral blood and bone marrow cells contribute to long-term engraftment after autologous transplantation

1995 • 496 citations

Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vector.

1993 • 485 citations

Expression of Thy-1 on human hematopoietic progenitor cells.

1993 • 477 citations

Use of adeno-associated virus as a mammalian DNA cloning vector: transduction of neomycin resistance into mammalian tissue culture cells.

1984 • 450 citations

Gene marking to determine whether autologous marrow infusion restores long-term haemopoiesis in cancer patients

1993 • 434 citations

Direct demonstration that autologous bone marrow transplantation for solid tumors can return a multiplicity of tumorigenic cells

1994 • 418 citations

[40] Use of retroviral vectors for gene transfer and expression

1993 • 412 citations

Adeno-associated virus (AAV) Rep proteins mediate complex formation between AAV DNA and its integration site in human DNA.

1994 • 379 citations

Combination of interleukins 3 and 6 preserves stem cell function in culture and enhances retrovirus-mediated gene transfer into hematopoietic stem cells.

1989 • 316 citations

Adeno-associated virus vectors preferentially transduce cells in S phase.

1994 • 272 citations

Sustained human hematopoiesis in immunodeficient mice by cotransplantation of marrow stroma expressing human interleukin-3: analysis of gene transduction of long-lived progenitors

1994 • 264 citations

Adeno-associated virus vectors in gene therapy

2005 • 252 citations

Cell Lines for the Production of Recombinant Adeno-Associated Virus

1995 • 250 citations

The level of mRNA encoding the amphotropic retrovirus receptor in mouse and human hematopoietic stem cells is low and correlates with the efficiency of retrovirus transduction.

1996 • 241 citations

Prospects for the Use of Adeno-Associated Virus as a Vector for Human Gene Therapy

1994 • 238 citations

Efficient gene transfer into nondividing cells by adeno-associated virus-based vectors

1994 • 228 citations

DNA synthesis and topoisomerase inhibitors increase transduction by adeno-associated virus vectors.

1995 • 220 citations

Implantation and maintenance of functional human bone marrow in SCID-hu mice

1992 • 209 citations

Fibronectin improves transduction of reconstituting hematopoietic stem cells by retroviral vectors: evidence of direct viral binding to chymotryptic carboxy-terminal fragments

1996 • 207 citations

Generation of a high-titer retroviral vector capable of expressing high levels of the human beta-globin gene.

1995 • 201 citations

Regulated high level expression of a human gamma-globin gene introduced into erythroid cells by an adeno-associated virus vector.

1992 • 196 citations

Long-term expression of human adenosine deaminase in rhesus monkeys transplanted with retrovirus-infected bone-marrow cells.

1992 • 190 citations

Long-term in vivo expression of a murine adenosine deaminase gene in rhesus monkey hematopoietic cells of multiple lineages after retroviral mediated gene transfer into CD34+ bone marrow cells

1993 • 185 citations

Long-term in vivo expression of a murine adenosine deaminase gene in rhesus monkey hematopoietic cells of multiple lineages after retroviral mediated gene transfer into CD34+ bone marrow cells

1993 • 168 citations

Normal and leukemic human stem cells assayed in SCID mice

1996 • 163 citations

Mutagenesis of retroviral vectors transducing human beta-globin gene and beta-globin locus control region derivatives results in stable transmission of an active transcriptional structure.

1994 • 162 citations

Improved retroviral gene transfer into murine and Rhesus peripheral blood or bone marrow repopulating cells primed in vivo with stem cell factor and granulocyte colony-stimulating factor.

1996 • 156 citations

Envelope-binding domain in the cationic amino acid transporter determines the host range of ecotropic murine retroviruses

1993 • 155 citations

In Vitro Expansion of Hematopoietic Progenitors and Maintenance of Stem Cells: Comparison Between FLT3/FLK-2 Ligand and KIT Ligand

1997 • 155 citations

Retroviral-mediated gene transfer into CD34-enriched human peripheral blood stem cells.

1993 • 154 citations

Stem cell factor, interleukin-3, and interleukin-6 promote retroviral- mediated gene transfer into murine hematopoietic stem cells

1992 • 147 citations

Development of HIV vectors for anti-HIV gene therapy.

1996 • 144 citations

Stromal support enhances cell-free retroviral vector transduction of human bone marrow long-term culture-initiating cells

1992 • 141 citations

Adeno-associated virus vectors transduce primary cells much less efficiently than immortalized cells

1995 • 139 citations

Survival and retrovirus infection of murine hematopoietic stem cells in vitro: effects of 5-FU and method of infection.

1991 • 137 citations

Inducible, High-Level Production of Infectious Murine Leukemia Retroviral Vector Particles Pseudotyped with Vesicular Stomatitis Virus G Envelope Protein

1995 • 136 citations

A New Strategy for Large-Scale Preparation of High-Titer Recombinant Adeno-Associated Virus Vectors by Using Packaging Cell Lines and Sulfonated Cellulose Column Chromatography

1996 • 133 citations

Comparison of the Effects of Growth Factors on Retroviral Vector-Mediated Gene Transfer and the Proliferative Status of Human Hematopoietic Progenitor Cells

1990 • 133 citations

Infection efficiency of T lymphocytes with amphotropic retroviral vectors is cell cycle dependent

1989 • 129 citations

Bone marrow collected 14 days after in vivo administration of granulocyte colony-stimulating factor and stem cell factor to mice has 10-fold more repopulating ability than untreated bone marrow

1996 • 127 citations

Adeno-Associated Virus: a Vector System for Efficient Introduction and Integration of DNA into a Variety of Mammalian Cell Types

1988 • 127 citations

Efficient retrovirus transduction of mouse pluripotent hematopoietic stem cells mobilized into the peripheral blood by treatment with granulocyte colony-stimulating factor and stem cell factor

1994 • 126 citations

Autologous transplantation of canine long-term marrow culture cells genetically marked by retroviral vectors

1992 • 125 citations

Gene transfer into hematopoietic stem cells: long-term maintenance of in vitro activated progenitors without marrow ablation.

1994 • 122 citations

Bone marrow collected 14 days after in vivo administration of granulocyte colony-stimulating factor and stem cell factor to mice has 10-fold more repopulating ability than untreated bone marrow

1996 • 119 citations

High-Efficiency Transfer of the T Cell Co-Stimulatory Molecule B7-2 to Lymphoid Cells Using High-Titer Recombinant Adeno-Associated Virus Vectors

1995 • 109 citations

Recombinant adeno-associated virus (rAAV)-mediated expression of a human gamma-globin gene in human progenitor-derived erythroid cells.

1994 • 103 citations

Expansion in vitro of retrovirally marked totipotent hematopoietic stem cells

1990 • 100 citations

Stromal support enhances cell-free retroviral vector transduction of human bone marrow long-term culture-initiating cells

1992 • 93 citations

Adeno-associated virus: a vector system for efficient introduction and integration of DNA into a variety of mammalian cell types.

1988 • 91 citations

Improved engraftment of human hematopoietic cells in severe combined immunodeficient (SCID) mice carrying human cytokine transgenes.

1995 • 87 citations

High-efficiency gene transfer to human hematopoietic cells maintained in long-term marrow culture [see comments]

1989 • 83 citations

Gene Transfer to Hematopoietic Cells

1996 • 79 citations

Retrovirus-mediated gene transduction into long-term repopulating marrow cells of dogs

1991 • 78 citations

Maintenance of murine long-term repopulating stem cells in ex vivo culture is affected by modulation of transforming growth factor-beta but not macrophage inflammatory protein-1 alpha activities

1996 • 76 citations

GENE TRANSFER TO HEMATOPOIETIC STEM CELLS: Implications for Gene Therapy of Human Disease

1996 • 72 citations

Retrovirus-mediated gene transduction into long-term repopulating marrow cells of dogs

1991 • 68 citations

High-Level Globin Gene Expression Mediated by a Recombinant Adeno-Associated Virus Genome That Contains the 3′ γ Globin Gene Regulatory Element and Integrates as Tandem Copies in Erythroid Cells

1997 • 64 citations

AAV as a viral vector for human gene therapy

1995 • 61 citations

Single-copy transduction and expression of human gamma-globin in K562 erythroleukemia cells using recombinant adeno-associated virus vectors: the effect of mutations in NF-E2 and GATA-1 binding motifs within the hypersensitivity site 2 enhancer [published erratum appears in Blood 1995 Feb 1;85(3):862]

1993 • 44 citations

Recombinant adeno-associated virus-mediated high-efficiency, transient expression of the murine cationic amino acid transporter (ecotropic retroviral receptor) permits stable transduction of human HeLa cells by ecotropic retroviral vectors

1996 • 42 citations

Retroviral Gene Transfer in Autologous Bone Marrow Transplantation for Adult Acute Leukemia

1996 • 37 citations

Retroviral vector sequences inhibit human β-globin gene expression in transgenic mice

1994 • 37 citations

The expression of neomycin phosphotransferase in human promyelocytic leukemia cells (HL60) delays their differentiation.

1988 • 30 citations

Positive selection of hematopoietic progenitors from marrow and peripheral blood for transplantation.

1990 • 28 citations