Long-term in vivo expression of a murine adenosine deaminase gene in rhesus monkey hematopoietic cells of multiple lineages after retroviral mediated gene transfer into CD34+ bone marrow cells

ADENOSINE-DEAMINASE DEFICIENCY IN TWO PATIENTS WITH SEVERELY IMPAIRED CELLULAR IMMUNITY

1972 • 1,654 citations

A safe packaging line for gene transfer: separating viral genes on two different plasmids

1988 • 1,118 citations

Construction and use of a safe and efficient amphotropic packaging cell line

1988 • 637 citations

Prospects for Human Gene Therapy

1984 • 548 citations

Helper virus induced T cell lymphoma in nonhuman primates after retroviral mediated gene transfer.

1992 • 544 citations

Progress Toward Human Gene Therapy

1989 • 484 citations

Treatment of Adenosine Deaminase Deficiency with Polyethylene Glycol–Modified Adenosine Deaminase

1987 • 450 citations

Demonstration of the origin of human mast cells from CD34+ bone marrow progenitor cells.

1991 • 369 citations

Rapid Cell Culture Assay Technique for Murine Leukaemia Viruses

1971 • 360 citations

Combination of interleukins 3 and 6 preserves stem cell function in culture and enhances retrovirus-mediated gene transfer into hematopoietic stem cells.

1989 • 316 citations

Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membrane-bound and secreted forms of the human homolog of the steel gene product, stem cell factor.

1992 • 306 citations

Adenosine deaminase deficiency with late onset of recurrent infections: Response to treatment with polyethylene glycol-modified adenosine deaminase

1988 • 217 citations

Long-term expression of human adenosine deaminase in rhesus monkeys transplanted with retrovirus-infected bone-marrow cells.

1992 • 190 citations

Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer.

1987 • 187 citations

Development of a high-titer retrovirus producer cell line capable of gene transfer into rhesus monkey hematopoietic stem cells.

1990 • 186 citations

Factors involved in production of helper virus-free retrovirus vectors

1986 • 181 citations

Protection of bone marrow transplant recipients from lethal doses of methotrexate by the generation of methotrexate-resistant bone marrow.

1987 • 144 citations

Survival and retrovirus infection of murine hematopoietic stem cells in vitro: effects of 5-FU and method of infection.

1991 • 137 citations

Long-term expression of human adenosine deaminase in mice transplanted with retrovirus-infected hematopoietic stem cells.

1989 • 133 citations

Autologous transplantation of canine long-term marrow culture cells genetically marked by retroviral vectors

1992 • 125 citations

Expression of human adenosine deaminase in murine hematopoietic cells.

1988 • 112 citations

Progress toward human gene therapy

1990 • 109 citations

Expression of human adenosine deaminase in mice reconstituted with retrovirus-transduced hematopoietic stem cells.

1990 • 105 citations

Overcoming interference to retroviral superinfection results in amplified expression and transmission of cloned genes.

1988 • 97 citations

Expression of human adenosine deaminase in mice after transplantation of genetically-modified bone marrow

1990 • 93 citations

Retrovirus-mediated gene transfer of human adenosine deaminase: expression of functional enzyme in murine hematopoietic stem cells in vivo.

1987 • 89 citations

High-efficiency gene transfer to human hematopoietic cells maintained in long-term marrow culture [see comments]

1989 • 83 citations

Retrovirus-mediated gene transduction into long-term repopulating marrow cells of dogs

1991 • 78 citations

Retroviral gene transfer of human adenosine deaminase in murine hematopoietic cells: effect of selectable marker sequences on long-term expression

1991 • 77 citations

Retroviral vector-mediated high-efficiency expression of adenosine deaminase (ADA) in hematopoietic long-term cultures of ADA-deficient marrow cells.

1989 • 73 citations

Gene therapy in perspective

1991 • 38 citations

Bone marrow transplantation for the treatment of immune deficiency states.

1990 • 33 citations

Expression of Human Adenosine Deaminase in Murine Hematopoietic Cells

1988 • 27 citations

Retrovirus-Mediated Gene Transfer of Human Adenosine Deaminase: Expression of Functional Enzyme in Murine Hematopoietic Stem Cells In Vivo

1987 • 26 citations

Restriction of expression of an integrated recombinant retrovirus in primary but not immortalized murine hematopoietic stem cells

1988 • 25 citations

Autologous transplantation of canine long-term marrow culture cells genetically marked by retroviral vectors

1992 • 12 citations

Restriction of expression of an integrated recombinant retrovirus in primary but not immortalized murine hematopoietic stem cells

1988 • 5 citations

Expression of human adenosine deaminase in mice after transplantation of genetically-modified bone marrow

1990 • 5 citations