Prospects for the Use of Adeno-Associated Virus as a Vector for Human Gene Therapy

Site-specific integration by adeno-associated virus.

1996 • 803 citations

Use of Adeno-Associated Virus as a General Transduction Vector for Mammalian Cells

1992 • 755 citations

Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression

1989 • 741 citations

Nucleotide sequence and organization of the adeno-associated virus 2 genome

1983 • 716 citations

Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vector.

1993 • 485 citations

The AAV origin binding protein Rep68 is an ATP-dependent site-specific endonuclease with DNA helicase activity

1990 • 467 citations

Cloning of adeno-associated virus into pBR322: rescue of intact virus from the recombinant plasmid in human cells.

1982 • 456 citations

Adeno-associated virus general transduction vectors: analysis of proviral structures

1988 • 347 citations

Expression of the cystic fibrosis transmembrane conductance regulator from a novel adeno-associated virus promoter.

1993 • 337 citations

Mapping and direct visualization of a region-specific viral DNA integration site on chromosome 19q13-qter

1991 • 322 citations

Genetics of adeno-associated virus: isolation and preliminary characterization of adeno-associated virus type 2 mutants

1984 • 303 citations

Integration of the adeno-associated virus genome into cellular DNA in latently infected human Detroit 6 cells

1980 • 293 citations

Cloning of infectious adeno-associated virus genomes in bacterial plasmids

1983 • 276 citations

Highly preferred targets for retrovirus integration

1988 • 262 citations

Dual-target Inhibition of HIV-1 in Vitro by Means of an Adeno-Associated Virus Antisense Vector

1992 • 206 citations

Structural Proteins of Adenovirus-Associated Viruses

1971 • 181 citations

Adeno-associated virus P5 promoter contains an adenovirus E1A-inducible element and a binding site for the major late transcription factor

1989 • 167 citations

Parvovirus replication.

1990 • 163 citations

Adeno-associated virus vectors

1992 • 161 citations

Expression from the adeno-associated virus p5 and p19 promoters is negatively regulated in trans by the rep protein

1989 • 161 citations

Synthesis of adeno-associated virus structural proteins requires both alternative mRNA splicing and alternative initiations from a single transcript

1988 • 157 citations

Organization of adeno-associated virus DNA in latently infected detroit 6 cells

1989 • 129 citations

Adeno-Associated Virus Gene Expression Inhibits Cellular Transformation by Heterologous Genes

1987 • 128 citations

Alternate mRNA splicing is required for synthesis of adeno-associated virus VP1 capsid protein

1988 • 125 citations

In vitro replication of adeno-associated virus DNA

1994 • 125 citations

A cascade of adenovirus early functions is required for expression of adeno-associated virus

1981 • 122 citations

Latent infection of KB cells with adeno-associated virus type 2

1986 • 108 citations

Assembly of viruslike particles by recombinant structural proteins of adeno-associated virus type 2 in insect cells

1992 • 108 citations

Observations of the carrier state in hamsters infected with Leptospira interrogans serotype pomona

1972 • 104 citations

Biologically active Rep proteins of adeno-associated virus type 2 produced as fusion proteins in Escherichia coli

1994 • 101 citations

Establishment and characterization of rat cell lines transformed by restriction endonuclease fragments of adenovirus 12 DNA

1977 • 100 citations

Adeno-associated virus: a vector system for efficient introduction and integration of DNA into a variety of mammalian cell types.

1988 • 91 citations

Sequence and symmetry requirements within the internal palindromic sequences of the adeno-associated virus terminal repeat

1988 • 81 citations

Targeted integration of transfected and infected adeno-associated virus vectors containing the neomycin resistance gene.

1994 • 81 citations

Organization of the adeno-associated virus (AAV) capsid gene: mapping of a minor spliced mRNA coding for virus capsid protein 1.

1988 • 69 citations

Adeno-associated virus 2-mediated gene transfer in murine hematopoietic progenitor cells.

1993 • 69 citations

Gene transfer into hematopoietic progenitor cells mediated by an adeno-associated virus vector

1988 • 60 citations

Replication of a human parvovirus nonsense mutant in mammalian cells containing an inducible amber suppressor

1989 • 56 citations

Efficient synthesis of adeno-associated virus structural proteins requires both adenovirus DNA binding protein and VA I RNA

1989 • 55 citations

Organization of the adeno-associated virus (AAV) capsid gene: Mapping of a minor spliced mRNA coding for virus capsid protein

1988 • 53 citations

The isopycnic, compartmentalized integration of Rous sarcoma virus sequences

1991 • 50 citations

Requirement for either early region 1a or early region 1b adenovirus gene products in the helper effect for adeno-associated virus

1984 • 48 citations

Gene expression in adeno-associated virus vectors: The effects of chimeric mRNA structure, helper virus, and adenovirus VA, RNA

1987 • 48 citations

Single-copy transduction and expression of human gamma-globin in K562 erythroleukemia cells using recombinant adeno-associated virus vectors: the effect of mutations in NF-E2 and GATA-1 binding motifs within the hypersensitivity site 2 enhancer [published erratum appears in Blood 1995 Feb 1;85(3):862]

1993 • 44 citations

Gene Transfer in Human Lymphocytes Using a Vector Based on Adeno-Associated Virus

1992 • 43 citations

Vero cells injected with adenovirus type 2 mRNA produce authentic viral polypeptide patterns: early mRNA promotes growth of adenovirus-associated virus.

1980 • 34 citations

Conserved chromatin structure in c-myc 5′-flanking DNA after viral transduction

1991 • 23 citations

Parvovirus RNA transcripts containing sequences not present in mature mRNA: a method for isolation of putative mRNA precursor sequences.

1979 • 18 citations

Unique events in parvovirus replication.

1984 • 8 citations