An in vivo function for the transforming Myc protein: elicitation of the angiogenic phenotype.

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

1983 • 2,350 citations

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

1991 • 1,650 citations

Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1

1994 • 1,460 citations

The implications of angiogenesis for the biology and therapy of cancer metastasis

1994 • 1,120 citations

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

1990 • 1,062 citations

Molecular architecture of basement membranes

1990 • 937 citations

Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors.

1997 • 841 citations

A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

1995 • 798 citations

Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation

1984 • 785 citations

Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.

1995 • 766 citations

Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas

1992 • 705 citations

A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1

1987 • 696 citations

Cdc25 cell-cycle phosphatase as a target of c-myc

1996 • 691 citations

The hypoxic cell: a target for selective cancer therapy--eighteenth Bruce F. Cain Memorial Award lecture.

1999 • 638 citations

Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation

1995 • 603 citations

A murine tumor producing a matrix of basement membrane.

1977 • 602 citations

Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice.

1999 • 599 citations

V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression.

1997 • 526 citations

How Tumors Become Angiogenic

1996 • 514 citations

Mice That Lack Thrombospondin 2 Display Connective Tissue Abnormalities That Are Associated with Disordered Collagen Fibrillogenesis, an Increased Vascular Density, and a Bleeding Diathesis

1998 • 488 citations

Myc and Max proteins possess distinct transcriptional activities

1992 • 478 citations

Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells

1989 • 475 citations

Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways

1997 • 470 citations

Reversible Activation of c-Myc in Skin

1999 • 468 citations

Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max

1992 • 458 citations

Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia.

1998 • 451 citations

The molecular role of Myc in growth and transformation: recent discoveries lead to new insights

1998 • 381 citations

Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ

1989 • 360 citations

c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II.

1994 • 313 citations

A series of mammalian expression vectors and characterisation of their expression of a reporter gene in stably and transiently transfected cells

1990 • 313 citations

Myc target genes

1997 • 289 citations

Control of cell proliferation by Myc

1998 • 251 citations

IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: Demonstration of a novel role for c-myc

1992 • 242 citations

Purification of a glycoprotein vascular endothelial cell mitogen from a rat glioma-derived cell line.

1990 • 230 citations

Expression of the extracellular matrix molecule thrombospondin inversely correlates with malignant progression in melanoma, lung and breast carcinoma cell lines

1994 • 222 citations

Reciprocal paracrine interactions between tumour cells and endothelial cells: the ‘angiogenesis progression’ hypothesis

1996 • 212 citations

Myc-Max heterodimers activate a DEAD box gene and interact with multiple E box-related sites in vivo.

1996 • 210 citations

Inhibition of Angiogenesis by Thrombospondin-2

1995 • 200 citations

Angiogenesis in the Mouse Cornea

1979 • 188 citations

Temporally and spatially regulated somatic mutagenesis in mice

1998 • 187 citations

Role of the SIKVAV Site of Laminin in Promotion of Angiogenesis and Tumor Growth: An In Vivo Matrigel Model

1992 • 185 citations

Angiogenesis spectrum in the stroma of B‐cell non‐Hodgkin's lymphomas. An immunohistochemical and ultrastructural study

1996 • 183 citations

Myc rescue of a mutant CSF-1 receptor impaired in mitogenic signalling

1991 • 175 citations

Inhibitory effects of antisense oligodeoxynucleotides targeting c-myc mRNA on smooth muscle cell proliferation and migration.

1993 • 165 citations

Myc represses the growth arrest gene gadd45

1997 • 149 citations

Establishing a Link between Oncogenes and Tumor Angiogenesis

1998 • 148 citations

Neoplastic transformation by the human gene N-myc.

1987 • 124 citations

Up-regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels.

1996 • 121 citations

SPARC and thrombospondin genes are repressed by the c-jun oncogene in rat embryo fibroblasts.

1994 • 108 citations

Viral Myc Oncoproteins in Infected Fibroblasts Down-modulate Thrombospondin-1, a Possible Tumor Suppressor Gene

1996 • 92 citations

Structure-function relationships of hydroxylated metabolites of tamoxifen that control the proliferation of estrogen-responsive T47D breast cancer cells in vitro.

1990 • 82 citations

Cell cycle: On target with Myc

1996 • 81 citations

Assay and purification of naturally occurring inhibitor of angiogenesis

1991 • 73 citations

Down‐regulation of endothelial cell growth inhibitors by enhanced MYCN oncogene expression in human neuroblastoma cells

1999 • 60 citations

Establishment of a Cell Line from the EHS Tumor: Biosynthesis of Basement Membrane Constituents and Characterization of a Hybrid Proteoglycan Containing Heparan and Chondroitin Sulfate Chains

1992 • 50 citations

Transformation by v-src causes transient induction followed by repression of mouse thrombospondin-1.

1994 • 50 citations

Tumour suppressor genes and angiogenesis: the role of TP53 in fibroblasts

1996 • 38 citations

Myb-dependent Regulation of Thrombospondin 2 Expression

1998 • 34 citations

Overproduction of v-Myc in the Nucleus and Its Excess Over Max Are Not Required for Avian Fibroblast Transformation

1993 • 13 citations

Characterization of c-myc-Transformed Rat Fibroblasts Resistant to Apoptosis Induced by Growth Factor Deprivation

1996 • 6 citations