An hypothesis: Phosphorylation fields as the source of positional information and cell differentiation—(cAMP, ATP) as the universal morphogenetic turing couple

The chemical basis of morphogenesis

1952 • 11,233 citations

A theory of biological pattern formation

1972 • 3,055 citations

Positional information and the spatial pattern of cellular differentiation

1969 • 2,957 citations

Oncogenes and signal transduction

1991 • 2,816 citations

THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES

1989 • 2,518 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

What Is Life

1944 • 2,479 citations

Order Out of Chaos

1984 • 2,382 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

Mathematical Models in Biology

2005 • 2,010 citations

Models of biological pattern formation

1982 • 1,851 citations

GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours

1989 • 1,405 citations

Role of calcium ions in regulation of mammalian intramitochondrial metabolism

1990 • 1,369 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

Prostaglandins and Thromboxanes

1978 • 1,310 citations

EUKARYOTIC TRANSCRIPTIONAL REGULATORY PROTEINS

1989 • 1,299 citations

Activation in vitro of NF-κB" by phosphorylation of its inhibitor IκB"

1990 • 1,202 citations

Cyclic AMP and the induction of eukaryotic gene transcription.

1988 • 1,041 citations

A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype

1988 • 998 citations

Intracellular phospholipases A

1980 • 989 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

Cellular Energy Metabolism and its Regulation

1977 • 961 citations

A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence

1989 • 914 citations

The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein

1988 • 771 citations

Growth factors in development, transformation, and tumorigenesis

1991 • 695 citations

Fluorescence ratio imaging of cyclic AMP in single cells

1991 • 686 citations

The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo

1989 • 672 citations

Dissipative structure: An explanation and an ecological example

1972 • 671 citations

The mechanical basis of morphogenesis

1981 • 666 citations

Chapter 6 Positional Information and Pattern Formation

1971 • 663 citations

Positional Information and Pattern Formation

2016 • 646 citations

Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures

1990 • 600 citations

Mathematical models in biology

1989 • 535 citations

Receptor-mediated activation of phospholipase A2 via GTP-binding proteins: arachidonic acid and its metabolites as second messengers

1988 • 512 citations

A molecular gradient in early Drosophila embryos and its role in specifying the body pattern

1986 • 504 citations

Role of phosphoinositides in transmembrane signaling.

1990 • 491 citations

Lithium inhibits adrenergic and cholinergic increases in GTP binding in rat cortex

1988 • 474 citations

The cyclic AMP-mediated stimulation of cell proliferation

1989 • 464 citations

Patterns and problems of development

1941 • 423 citations

Regulation of camp-inducible genes by creb

1990 • 416 citations

Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction

1990 • 412 citations

Myb DNA binding inhibited by phosphorylation at a site deleted during oncogenic activation

1990 • 355 citations

Transcriptional regulation by dimerization: Two sides to an incestuous relationship

1990 • 343 citations

Ia binding ligands and cAMP stimulate nuclear translocation of PKC in B lymphocytes

1987 • 321 citations

Patterns and Problems of Development

1942 • 318 citations

Lateral inhibition and the development of the sensory bristles of the adult peripheral nervous system of Drosophila

1990 • 316 citations

Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant

1991 • 302 citations

From Egg to Embryo

1983 • 277 citations

Chemical Messengers in Development: A Hypothesis

1974 • 255 citations

Regulation of transcription by cyclic AMP-dependent protein kinase.

1989 • 247 citations

Transcription factors: a new family gathers at the cAMP response site

1990 • 244 citations

Review Lecture: Protein phosphorylation and hormone action

1988 • 237 citations

Cyclic-AMP-responsive transcriptional activation of CREB-327 involves interdependent phosphorylated subdomains.

1990 • 236 citations

Negative and positive regulation by transcription factor cAMP response element-binding protein is modulated by phosphorylation.

1990 • 226 citations

The Arrow of Time

1990 • 226 citations

Autoregulation of pit-1 gene expression mediated by two cis-active promoter elements

1990 • 224 citations

The Elements of Experimental Embryology

1934 • 219 citations

Activation of facilitation calcium channels in chromaffin cells by D1 dopamine receptors through a cAMP/protein kinase A-dependent mechanism

1990 • 218 citations

Lateral inhibition during vulval induction in Caenorhabditis elegans

1988 • 218 citations

Regulation of the pituitary-specific homeobox gene GHF1 by cell-autonomous and environmental cues

1990 • 215 citations

Gap junctional communication and development

1989 • 215 citations

Activin can induce the formation of axial structures and is expressed in the hypoblast of the chick

1990 • 213 citations

Localized surface activity of torso, a receptor tyrosine kinase, specifies terminal body pattern in Drosophila.

1989 • 213 citations

IP-1: A dominant inhibitor of Fos/Jun whose activity is modulated by phosphorylation

1991 • 212 citations

Expression of GHF-1 protein in mouse pituitaries correlates both temporally and spatially with the onset of growth hormone gene activity

1990 • 208 citations

Is contiguity detection in classical conditioning a system or a cellular property? Learning in Aplysia suggests a possible molecular site

1988 • 202 citations

Isolation and characterization of Drosophila cAMP-dependent protein kinase genes.

1988 • 184 citations

Region-Specific Cell Activities in Amphibian Gastrulation

1986 • 180 citations

The Calcium Signal

1985 • 176 citations

Dynamics of the distribution of cyclic AMP-dependent protein kinase in living cells.

1990 • 165 citations

Bimodal and graded expression of theXenopushomeobox geneXhox3during embryonic development

1989 • 161 citations

Generation of biological patterns and form: Some physical, mathematical, and logical aspects

1981 • 159 citations

Plasma membrane localization of the Toll protein in the syncytial Drosophila embryo: importance of transmembrane signaling for dorsal–ventral pattern formation

1991 • 140 citations

cAMP delays disappearance of gap junctions between pairs of rat hepatocytes in primary culture

1989 • 137 citations

Senescence and rejuvenescence

1915 • 134 citations

A Mouse Macrophage Factor Induces Head Structures and Organizes a Body Axis in Xenopus

1990 • 130 citations

Putting it on and taking it off: Phosphoprotein phosphatase involvement in cell cycle regulation

1989 • 119 citations

A picture of the global bifurcation diagram in ecological interacting and diffusing systems

1982 • 118 citations

Pattern Formation in Biological Development

1978 • 117 citations

Glucagon stimulates the cardiac Ca2+ current by activation of adenylyl cyclase and inhibition of phosphodiesterase

1990 • 114 citations

Interleukin 4 activates human B lymphocytes via transient inositol lipid hydrolysis and delayed cyclic adenosine monophosphate generation

1990 • 113 citations

Modulation of glycine receptor chloride channels by cAMP-dependent protein kinase in spinal trigeminal neurons

1990 • 112 citations

Individuality in organisms

1915 • 110 citations

The Cycling of Calcium as an Intracellular Messenger

1989 • 110 citations

Homeodomain proteins and the regulation of gene expression

1990 • 109 citations

Neural induction is mediated by cross-talk between the protein kinase C and cyclic AMP pathways

1989 • 109 citations

The physiological gradients

1928 • 108 citations

Activators and Inhibitors in Pattern Formation

1978 • 100 citations

Gap junctional communication during limb cartilage differentiation

1991 • 94 citations

Growth hormone gene regulation: a paradigm for cell-type-specific gene activation

1990 • 93 citations

Physiological foundations of behavior

1924 • 92 citations

Fibroblast growth factor during mesoderm induction in the early chick embryo

1990 • 85 citations

Fetal and adult localization of C/EBP: evidence for combinatorial action of transcription factors in cell-specific gene expression

1990 • 79 citations

Retinoic acid, dibutyryl-cAMP, and differentiation affect the expression of retinoic acid receptors in F9 cells.

1990 • 78 citations

The role of gap junctions in patterning of the chick limb bud.

1990 • 77 citations

DIFFERENTIAL SUSCEPTIBILITY AS A BASIS FOR MODIFICATION AND CONTROL OF EARLY DEVELOPMENT IN THE FROG

1919 • 75 citations

Intracellular calcium

1984 • 74 citations

Nonlinear Phenomena in Physics and Biology

1981 • 73 citations

Structure and expression pattern of the murine Hox-3.2 gene

1990 • 73 citations

The Drosophila dunce locus: learning and memory genes in the fly

1991 • 72 citations

Senescence and Rejuvenescence.

1915 • 71 citations

Analysis of maternal effect mutant combinations elucidates regulation and function of the overlap of hunchback and Krüppel gene expression in the Drosophila blastoderm embryo

1989 • 68 citations

Induction by Soluble Factors of Organized Axial Structures in Chick Epiblasts

1990 • 59 citations

Origins of human cancer revisited

1990 • 53 citations

The egg came first, of course!

1989 • 49 citations

Pattern formation in the Drosophila embryo

1981 • 49 citations

A bifurcation analysis of pattern formation in a diffusion governed morphogenetic field

1977 • 48 citations

SOME CONSIDERATIONS CONCERNING THE NATURE AND ORIGIN OF PHYSIOLOGICAL GRADIENTS

1920 • 44 citations

Protein Phosphorylation and Hormone Action

1976 • 43 citations

Establishment of the Deformed expression stripe requires the combinatorial action of coordinate, gap and pair-rule proteins.

1990 • 43 citations

We may not have a morphogen

1991 • 42 citations

Protein phosphorylation and dephosphorylation

1990 • 40 citations

Phospholipase a and lysophospholipase activities in isolated fat cells: Effect of cyclic 3'.5'-AMP

1972 • 40 citations

The Drosophila dunce locus: learning and memory genes in the fly

1991 • 38 citations

Wavelike isomorphic prepatterns in development

1989 • 38 citations

Regulation of eukaryotic transcription factors by post-translational modification

1989 • 36 citations

Induction of Neural Differentiation in Cultures of Amphibian Undetermined Presumptive Epidermis by Cyclic AMP Derivatives

1975 • 35 citations

Organizers in Development and the Organizer Concept

1946 • 35 citations

Characterization of protein kinase C in early Xenopus embryogenesis

1990 • 34 citations

Spatial harmonics and pattern specification in early Drosophila development. Part I. Bifurcation sequences and gene expression

1990 • 33 citations

Modulation of Ion Channels by Phosphorylation and Second Messengers

1987 • 30 citations

Stage-specific phosphorylation of the fushi tarazu protein during Drosophila development.

1989 • 26 citations

Motifs of protein phosphorylation and mechanisms of reversible covalent regulation

1991 • 23 citations

Individuality in organisms

1915 • 20 citations

Xenopus mesoderm induction: evidence for early size control and partial autonomy for pattern development by onset of gastrulation

1989 • 20 citations

Phorbol esters increase adenylate cyclase activity and stability in pituitary membranes

1988 • 20 citations

Developmental control in animals and plants.

1984 • 19 citations

Classification in bifurcation theory and reaction-diffusion systems

1980 • 18 citations

Adenosine 3′,5′-Monophosphate: Regional Differences in Chick Embryos at the Head Process Stage

1972 • 17 citations

Serine/threonine protein kinases in Drosophila

1990 • 16 citations

Dynamics of the distribution of cyclic AMP-dependent protein kinase in living cells

1991 • 16 citations

Characterization of a cyclic AMP regulatory element DNA-binding Protein

1990 • 15 citations

Role of cyclic AMP and ammonia in induction and maintenance of post-aggregative differentiation in a suspension culture of Dictyostelium discoideum

1988 • 15 citations

Differential susceptibility as a basis for modification and control of development in the frog. II. Types of modification seen in later developmental stages

1922 • 13 citations

The second messenger system as the morphogenetic field

1989 • 12 citations

Physiological foundations of behaviour

1926 • 12 citations

Tailoring and coupling of reaction-diffusion systems to obtain reproducible complex pattern formation during development of the higher organisms

1989 • 12 citations

Mitogenic signalling in murine 3T3 cells: the cyclic AMP pathway

1989 • 12 citations

Genetic control of cell communication in C. elegans development

1990 • 11 citations

Bistability and control for ATP synthase and adenylate cyclase is obtained by the removal of substrate inhibition

1989 • 10 citations

The old and the new in transformed cell signalling: glycolysis, diacylglycerol and protein kinase C.

1990 • 6 citations

On the molecular basis of memory

1989 • 3 citations

Cyclic GMP is not involved in neural induction inXenopus laevis

1990 • 3 citations

Chemical bistability

1984 • 2 citations

Deleted Work

1955 • 0 citations