Proinflammatory and Immunoregulatory Functions of Interleukin-12

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 • 1,989 citations

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.

1995 • 1,560 citations

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

1993 • 1,409 citations

Antitumor and antimetastatic activity of interleukin 12 against murine tumors.

1993 • 1,206 citations

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

1992 • 1,168 citations

Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes

1994 • 1,066 citations

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

1993 • 991 citations

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.

1991 • 976 citations

In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.

1996 • 920 citations

Interleukin-12 and its role in the generation of TH1 cells

1993 • 869 citations

Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.

1991 • 861 citations

Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

1993 • 837 citations

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.

1993 • 792 citations

Recombinant interleukin 12 cures mice infected with Leishmania major.

1993 • 776 citations

Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response.

1993 • 738 citations

Inhibition of Angiogenesis In Vivo by Interleukin 12

1995 • 734 citations

Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.

1994 • 729 citations

The Adjuvant Effect of Interleukin-12 in a Vaccine Against Leishmania major

1994 • 687 citations

Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells.

1990 • 679 citations

Interleukin‐12 is produced by dendritic cells and mediates T helper 1 development as well as interferon‐γ production by T helper 1 cells

1996 • 676 citations

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

1995 • 675 citations

The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells.

1996 • 663 citations

Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice.

1995 • 626 citations

Mechanism of Suppression of Cell-Mediated Immunity by Measles Virus

1996 • 564 citations

Interleukin‐12 is required for interferon‐γ production and lethality in lipopolysaccharide‐induced shock in mice

1995 • 491 citations

Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10

1996 • 480 citations

Cloning and expression of murine IL-12.

1992 • 474 citations

Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor).

1991 • 471 citations

Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration.

1995 • 458 citations

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.

1995 • 446 citations

Mouse interleukin‐12 (IL‐12) p40 homodimer: a potent IL‐12 antagonist

1995 • 441 citations

Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones.

1994 • 438 citations

Impaired interleukin 12 production in human immunodeficiency virus-infected patients.

1994 • 435 citations

Developmental commitment to the Th2 lineage by extinction of IL-12 signaling

1995 • 429 citations

Activated T cells induce interleukin‐12 production by monocytes via CD40‐CD40 ligand interaction

1995 • 427 citations

IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis.

1995 • 427 citations

Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity.

1995 • 407 citations

An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection

1995 • 403 citations

Restoration of HIV-Specific Cell-Mediated Immune Responses by Interleukin-12 in Vitro

1993 • 397 citations

An absolute and restricted requirement for IL-12 in natural killer cell IFN-gamma production and antiviral defense. Studies of natural killer and T cell responses in contrasting viral infections.

1996 • 384 citations

Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo

1994 • 373 citations

Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production.

1995 • 372 citations

Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF.

1992 • 369 citations

Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells.

1994 • 367 citations

B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation.

1994 • 367 citations

Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection.

1994 • 365 citations

Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12.

1995 • 350 citations

Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion.

1996 • 349 citations

Antiproliferative effect of IFN-gamma in immune regulation. III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-gamma.

1989 • 349 citations

Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha.

1995 • 348 citations

Dendritic cells and macrophages are required for Th1 development of CD4⁺ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-_γ production is IFN-_γ-dependent

1993 • 346 citations

Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes

1995 • 341 citations

Natural killer (NK) cell stimulatory factor or IL-12 has differential effects on the proliferation of TCR-alpha beta+, TCR-gamma delta+ T lymphocytes, and NK cells.

1992 • 333 citations

CD40 Ligand Is Required for Protective Cell-Mediated Immunity to Leishmania major

1996 • 332 citations

Regulation of human cytolytic lymphocyte responses by interleukin-12

1992 • 331 citations

IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection.

1995 • 325 citations

Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice.

1996 • 319 citations

IL-12-induced protection against blood-stage Plasmodium chabaudi AS requires IFN-gamma and TNF-alpha and occurs via a nitric oxide-dependent mechanism.

1995 • 314 citations

Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10.

1996 • 311 citations

Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130.

1994 • 309 citations

Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit.

1996 • 306 citations

Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma.

1994 • 305 citations

Protective Role of CD40 in Leishmania major Infection at Two Distinct Phases of Cell-Mediated Immunity

1996 • 302 citations

IL-12 receptor. II. Distribution and regulation of receptor expression.

1992 • 298 citations

Effects of IL-12 on helper T cell-dependent immune responses in vivo.

1994 • 294 citations

The interleukin‐12 subunit p40 specifically inhibits effects of the interleukin‐12 heterodimer

1993 • 292 citations

Lack of Interferon γ Receptor β Chain and the Prevention of Interferon γ Signaling in T_H1 Cells

1995 • 292 citations

T helper type 1 development of naive CD4⁺ T cells requires the coordinate action of interleukin‐12 and interferon‐γ and is inhibited by transforming growth factor‐β

1994 • 288 citations

Interleukin‐12 production by human polymorphonuclear leukocytes

1995 • 285 citations

Mechanisms of IFN-gamma induction by natural killer cell stimulatory factor (NKSF/IL-12). Role of transcription and mRNA stability in the synergistic interaction between NKSF and IL-2.

1992 • 284 citations

T helper type 1/T helper type 2 cytokines and T cell death: preventive effect of interleukin 12 on activation-induced and CD95 (FAS/APO-1)-mediated apoptosis of CD4+ T cells from human immunodeficiency virus-infected persons.

1995 • 283 citations

Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites.

1994 • 281 citations

The role of IL-12 in the induction of organ-specific autoimmune diseases

1995 • 277 citations

Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology.

1994 • 274 citations

IL-1 beta is required for IL-12 to induce production of IFN-gamma by NK cells. A role for IL-1 beta in the T cell-independent mechanism of resistance against intracellular pathogens.

1995 • 253 citations

Interleukin‐12/T cell stimulating factor, a cytokine with multiple effects on T helper type 1 (T_h1) but not on T_h2 cells

1993 • 241 citations

Interleukin 12, interferon gamma, and tumor necrosis factor alpha are the key cytokines of the generalized Shwartzman reaction.

1994 • 235 citations

Effects of IL-12 on the response and susceptibility to experimental viral infections.

1994 • 233 citations

Interleukin 12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon

1994 • 223 citations

Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids.

1995 • 215 citations

IL-12 prevents mortality in mice infected with Histoplasma capsulatum through induction of IFN-gamma.

1995 • 214 citations

IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses.

1996 • 208 citations

Type 1/type 2 cytokine modulation of T-cell programmed cell death as a model for human immunodeficiency virus pathogenesis.

1994 • 206 citations

Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients.

1992 • 198 citations

IL-12 synthesis by human Langerhans cells.

1996 • 186 citations

Interleukin 12 induction of interferon gamma-dependent protection against malaria.

1994 • 185 citations

CD40/CD40 ligand interactions are required for T cell‐dependent production of interleukin‐12 by mouse macrophages

1996 • 184 citations

Differential regulation of interleukin-12 (IL-12), tumor necrosis factor alpha, and IL-1 beta production in human myeloid leukemia cell lines and peripheral blood mononuclear cells

1994 • 182 citations

Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam.

1995 • 179 citations

Modulation of perforin and granzyme messenger RNA expression in human natural killer cells.

1993 • 176 citations

Defective monocyte costimulation for IFN-gamma production in familial disseminated Mycobacterium avium complex infection: abnormal IL-12 regulation.

1996 • 174 citations

Role of Interferon-γ in Mediating the Antitumor Efficacy of Interleukin-12

1995 • 172 citations

Natural killer cell stimulatory factor (NKSF) or interleukin-12 is a key regulator of immune response and inflammation

1992 • 164 citations

IL-10 production is enhanced in human T cells by IL-12 and IL-6 and in monocytes by tumor necrosis factor-alpha.

1996 • 163 citations

Endogenous IL-12 is required for control of Th2 cytokine responses capable of exacerbating leishmaniasis in normally resistant mice.

1995 • 162 citations

Cooperation of Natural Killer Cell Stimulatory Factor/Interleukin-12 with Other Stimuli in the Induction of Cytokines and Cytotoxic Cell-Associated Molecules in Human T and NK Cells

1994 • 162 citations

Cloning and characterization of a mouse IL-12 receptor-beta component.

1995 • 155 citations

Enhancing effect of natural killer cell stimulatory factor (NKSF/interleukin‐12) on cell‐mediated cytotoxicity against tumor‐derived and virus‐infected cells

1993 • 150 citations

IL-12 protects mice against pulmonary and disseminated infection caused by Cryptococcus neoformans

1996 • 149 citations

IL-12 inhibits the production of IL-4 and IL-10 in allergen-specific human CD4+ T lymphocytes.

1995 • 144 citations

IL-12 is both required and prognostic in vivo for T helper type 1 differentiation in murine candidiasis.

1994 • 140 citations

Interferon gamma-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major.

1994 • 137 citations

Identification and induction of human keratinocyte-derived IL-12.

1994 • 137 citations

IL-12 regulates T helper type 1 cytokine responses in human infectious disease.

1994 • 136 citations

Cytokine treatment of central nervous system infection: efficacy of interleukin-12 alone and synergy with conventional antifungal therapy in experimental cryptococcosis

1994 • 133 citations

Differential effects of interleukin‐12 on the development of naive mouse CD4⁺ T cells

1994 • 132 citations

IL-12 is essential for resistance against Yersinia enterocolitica by triggering IFN-gamma production in NK cells and CD4+ T cells.

1996 • 130 citations

Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5

1992 • 130 citations

Interleukin 12 is effective treatment for an established systemic intracellular infection: experimental visceral leishmaniasis.

1995 • 126 citations

Effect of interleukin 12 neutralization on host resistance and gamma interferon production in mouse typhoid

1996 • 122 citations

Role of interferon-gamma in interleukin 12-induced pathology in mice.

1995 • 122 citations

IL-12 induces human T cells secreting IL-10 with IFN-gamma.

1996 • 121 citations

IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice and decreases T helper 2 cytokine expression, IgE production, and tissue eosinophilia.

1995 • 121 citations

Interleukin-12 gene expression after viral infection in the mouse

1995 • 119 citations

Endogenous interleukin-12 is involved in resistance to Brucella abortus infection

1995 • 118 citations

Interleukin‐12 regulates the proliferation of Th1, but not Th2 or Th0, clones

1994 • 118 citations

B7-1 and interleukin 12 synergistically induce effective antitumor immunity.

1995 • 118 citations

IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines.

1994 • 116 citations

Studies on the role of interleukin-12 in acute murine toxoplasmosis.

1995 • 111 citations

Cytotoxic lymphocyte maturation factor (interleukin 12) is a synergistic growth factor for hematopoietic stem cells.

1993 • 111 citations

Endogenous and exogenous interleukin-12 augment the protective immune response in mice orally challenged with Salmonella dublin

1996 • 108 citations

Neutralization of IL-12 in vivo prevents induction of contact hypersensitivity and induces hapten-specific tolerance.

1996 • 107 citations

IL-12 synergizes with IL-2 and other stimuli in inducing IL-10 production by human T cells.

1996 • 96 citations

Effect of anti-interleukin 12 treatment on murine lyme borreliosis.

1996 • 96 citations

HIV infection suppresses type 1 lymphokine and IL-12 responses to Toxoplasma gondii but fails to inhibit the synthesis of other parasite-induced monokines.

1995 • 93 citations

Molecular cloning and characterization of murine IL-12 genes.

1996 • 93 citations

Cytokine Patterns at the Site of Mycobacterial Infection

1994 • 93 citations

Interleukin-12 is chemotactic for natural killer cells and stimulates their interaction with vascular endothelium

1994 • 92 citations

Biochemical characterization and protein kinase C dependency of monokine-inducing activities of Toxoplasma gondii

1996 • 92 citations

Secondary response to Listeria infection requires IFN-gamma but is partially independent of IL-12.

1995 • 90 citations

Role of IL-12 in human B lymphocyte proliferation and differentiation.

1995 • 89 citations

In Vitro Restoration of T Cell Immune Function in Human Immunodeficiency Virus-Positive Persons: Effects of Interleukin (IL)-12 and Anti-IL-IO

1996 • 88 citations

The stimulatory effects of interleukin (IL)-12 on hematopoiesis are antagonized by IL-12-induced interferon gamma in vivo.

1995 • 86 citations

Biological function and distribution of human interleukin‐12 receptor β chain

1996 • 83 citations

Infection with Leishmania major induces interleukin-12 production in vivo

1994 • 83 citations

Differential Effects of IL12 and IL2 on Expression and Function of Cellular Adhesion Molecules on Purified Human Natural Killer Cells

1993 • 81 citations

Cellular and molecular mechanisms of the IL-12-induced increase in allospecific murine cytolytic T cell activity. Implications for the age-related decline in CTL.

1994 • 79 citations

Nonviable bacterial antigens administered with IL-12 generate antigen-specific T cell responses and protective immunity against Listeria monocytogenes.

1995 • 79 citations

Structure and chromosomal location of the mouse interleukin‐12 p35 and p40 subunit genes

1996 • 78 citations

Differential expression of mRNA encoding interleukin‐12 p35 and p40 subunits in situ

1994 • 77 citations

Keratinocyte-derived T cell costimulation induces preferential production of IL-2 and IL-4 but not IFN-gamma.

1994 • 75 citations

In vitro maturation of human neonatal CD4 T lymphocytes. I. Induction of IL-4-producing cells after long-term culture in the presence of IL-4 plus either IL-2 or IL-12.

1994 • 75 citations

Dual stimulatory and inhibitory effect of NK cell stimulatory factor/IL-12 on human hematopoiesis.

1994 • 68 citations

IL-12 inhibits IL-4 synthesis in keyhole limpet hemocyanin-primed CD4+ T cells through an effect on antigen-presenting cells.

1995 • 67 citations

B cells regulate CD40 ligand-induced IL-12 production in antigen-presenting cells (APC) during T cell/APC interactions.

1997 • 66 citations

Interleukin-12 Treatment during Immunization Elicits a T Helper Cell Type 1-like Immune Response in Mice Challenged with Respiratory Syncytial Virus and Improves Vaccine Immunogenicity

1995 • 65 citations

IL-12 stimulates an antiviral type 1 cytokine response but lacks adjuvant activity in IFN-gamma-receptor-deficient mice.

1995 • 65 citations

Dissection of strain difference in acquired protective immunity against Mycobacterium bovis Calmette-Guérin bacillus (BCG). Macrophages regulate the susceptibility through cytokine network and the induction of nitric oxide synthase.

1995 • 64 citations

IL-12 produced by antigen-presenting cells induces IL-2-independent proliferation of T helper cell clones.

1996 • 62 citations

IL-12 protects bone marrow from and sensitizes intestinal tract to ionizing radiation.

1994 • 62 citations

Preferential expression of interleukin‐12 or interleukin‐4 by murine bone marrow mast cells derived in mast cell growth factor or interleukin‐3

1994 • 61 citations

Bacterial superantigen-induced human lymphocyte responses are nitric oxide dependent and mediated by IL-12 and IFN-gamma.

1996 • 59 citations

The in vivo antiviral activity of interleukin-12 is mediated by gamma interferon

1995 • 59 citations

MAPPING OF GENES CONTROLLING LEISHMANIA MAJOR INFECTION IN CXS RECOMBINANT INBRED MICE

1993 • 58 citations

Endogenous interleukin-12 is involved in resistance of mice to Mycobacterium avium complex infection

1995 • 57 citations

IL-12 Inhibits Apoptosis Induced in a Human Th1 Clone by gp120/CD4 Cross-Linking and CD3/TCR Activation or by IL-2 Deprivation

1995 • 57 citations

IL-12 expression in AIDS-related lymphoma B cell lines.

1996 • 56 citations

Administration of Recombinant Interleukin-12 to Mice Suppresses Hematopoiesis in the Bone Marrow but Enhances Hematopoiesis in the Spleen

1995 • 53 citations

Interleukin-12 synergizes with interleukin-3 and steel factor to enhance recovery of murine hemopoietic stem cells in liquid culture.

1993 • 53 citations

Recombinant interleukin-12 enhances resistance of mice to Listeria monocytogenes infection

1994 • 53 citations

Interleukin-12 Stimulates B Cell Growth by Inducing IFN-γ

1996 • 51 citations

Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor.

1993 • 50 citations

Dysregulated production of interleukin-10 (IL-10) and IL-12 by peripheral blood lymphocytes from human immunodeficiency virus-infected individuals is associated with altered proliferative responses to recall antigens

1995 • 47 citations

IL12 in Candida albicans infections

1995 • 45 citations

IL-12 modulation of T helper responses to the filarial helminth, Brugia malayi.

1995 • 44 citations

Interleukin-12 induces tyrosine phosphorylation and activation of 44-kD mitogen-activated protein kinase in human T cells

1994 • 43 citations

Protection of Mice from Group A Streptococcal Skin Infection by Interleukin-12

1995 • 41 citations

Interleukin-12 expression in human lymphomas and nonneoplastic lymphoid disorders

1995 • 40 citations

Priming for high interferon-gamma production induced by interleukin-12 in both CD4+ and CD8+ T cell clones from HIV-infected patients.

1995 • 39 citations

Interleukin-12 and malaria

1995 • 38 citations

Inhibition of murine B1 lymphocytes by interleukin-12

1996 • 38 citations

Multiple Effects on Peripheral Hematology Following Administration of Recombinant Human Interleukin 12 to Nonhuman Primates

1994 • 37 citations

Protection of mice from Mycobacterium avium infection by recombinant interleukin-12

1995 • 34 citations

Constitutive Expression of Both Subunits of Interleukin-12 in Human Keratinocytes

1996 • 33 citations

Acute induction and priming for cytokine production in lymphocytes

1996 • 32 citations

Development in vitro of human CD4⁺ thymocytes into functionally mature Th2 cells. Exogenous interleukin‐12 is required for priming thymocytes to produce both Th1 cytokines and interleukin‐10

1996 • 31 citations

IL12 receptors and receptor antagonists

1995 • 27 citations

Increased numbers of interleukin-12-producing cells in human tuberculosis

1996 • 24 citations

Selective Modulation of IFN-γ mRNA Stability by IL-12/NKSF

1994 • 22 citations

The effects of IL12 on B-cell subset function

1995 • 20 citations

Role of IL12 in HIV disease/AIDS

1995 • 19 citations

Interleukin-12 and its role in cutaneous sensitization

1995 • 18 citations

Murine IL-12 is involved in Calmette-Guérin bacillus-induced sensitization and is by itself sufficient to sensitize mice to the lethal effects of human TNF1.

1996 • 13 citations

Effect of 12 Neutralizing Anti‐Cytokine Antibodies on In Vitro Activation of B‐Cells. Interleukin‐12 is Required by B1a but not B2 Cells

1996 • 9 citations

Human Keratinocyte-Derived IL-12 Affects LC-Induced Allogeneic T-Cell Responses

1995 • 7 citations

Leishmania major Metacyclogenesis Modulates Ability to Induce IL‐12

1996 • 5 citations