Biochemical characterization and protein kinase C dependency of monokine-inducing activities of Toxoplasma gondii

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

IL-10 inhibits cytokine production by activated macrophages.

1991 • 2,919 citations

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

1993 • 1,409 citations

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

1992 • 1,168 citations

Interferon-γ: the Major Mediator of Resistance Against Toxoplasma gondii

1988 • 1,150 citations

Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.

1991 • 861 citations

Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

1993 • 837 citations

Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.

1994 • 729 citations

Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine.

1991 • 617 citations

IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis.

1995 • 427 citations

Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors.

1989 • 385 citations

Importance of endogenous IFN-gamma for prevention of toxoplasmic encephalitis in mice.

1989 • 355 citations

Acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF-alpha and correlates with the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage activation.

1993 • 345 citations

Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni.

1993 • 337 citations

Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice.

1996 • 319 citations

Toxoplasma gondii induces a T-independent IFN-gamma response in natural killer cells that requires both adherent accessory cells and tumor necrosis factor-alpha.

1993 • 271 citations

Chemical, Physical, and Biological Properties of a Lipopolysaccharide from Escherichia coli K-235^*

1967 • 258 citations

IL-1 beta is required for IL-12 to induce production of IFN-gamma by NK cells. A role for IL-1 beta in the T cell-independent mechanism of resistance against intracellular pathogens.

1995 • 253 citations

Cytokine gene expression after in vivo primary immunization with goat antibody to mouse IgD antibody.

1991 • 250 citations

Involvement of protein kinase C and protein tyrosine kinase in lipopolysaccharide-induced TNF-alpha and IL-1 beta production by human monocytes.

1994 • 224 citations

Inhibition of murine malaria (Plasmodium chabaudi) in vivo by recombinant interferon-gamma or tumor necrosis factor, and its enhancement by butylated hydroxyanisole.

1987 • 219 citations

Interleukin-12 enhances murine survival against acute toxoplasmosis

1994 • 203 citations

Taxol increases steady-state levels of lipopolysaccharide-inducible genes and protein-tyrosine phosphorylation in murine macrophages.

1992 • 180 citations

A recombinant Leishmania antigen that stimulates human peripheral blood mononuclear cells to express a Th1-type cytokine profile and to produce interleukin 12.

1995 • 157 citations

Differential inhibition of IL-1 and TNF-alpha mRNA expression by agents which block second messenger pathways in murine macrophages.

1988 • 152 citations

Host resistance to Toxoplasma gondii: model for studying the selective induction of cell-mediated immunity by intracellular parasites.

1993 • 134 citations

A protective role for endogenous tumor necrosis factor in Toxoplasma gondii infection

1992 • 133 citations

Effect of liposome-mediated macrophage depletion on LPS-induced cytokine gene expression and radioprotection.

1995 • 117 citations

IL‐10 mediates immunosuppression following primary infection with Toxoplasma gondii in mice

1995 • 109 citations

Involvement of protein kinase C during taxol-induced activation of murine peritoneal macrophages.

1995 • 83 citations

Infection with Leishmania major induces interleukin-12 production in vivo

1994 • 83 citations

Macrophage activation during Plasmodium chabaudi AS infection in resistant C57BL/6 and susceptible A/J mice

1992 • 56 citations

Augmentation of NK cell activity by soluble and particulate fractions of Toxoplasma gondii.

1983 • 47 citations

Secretion of IL-1: role of protein kinase C.

1992 • 47 citations

A monoclonal antibody that recognizes phosphatidylinositol inhibits induction of tumor necrosis factor alpha by different strains of Plasmodium falciparum

1994 • 37 citations

Toxoplasma gondii soluble antigen induces a subset of lipopolysaccharide-inducible genes and tyrosine phosphoproteins in peritoneal macrophages

1994 • 36 citations

Enhancement of human natural killer cell activity by subcellular components of Toxoplasma gondii

1984 • 30 citations

Pharmacologic evidence for the requirement of protein kinase C in IFN-induced macrophage Fc gamma receptor and Ia antigen expression.

1990 • 26 citations

Toxoplasma gondii and toxoplasmosis.

1993 • 16 citations

Toxins, cytokines, immunity and pathology

1991 • 11 citations

Differential regulation of LPS-induced IL-1β and EL-1 receptor antagonist mRNA by IFNα and IFNγ in murine peritoneal macrophages

1994 • 7 citations

Deleted Work

1955 • 0 citations