A Ternary Complex Factor-Dependent Mechanism Mediates Induction of egr-1 through Selective Serum Response Elements following Antigen Receptor Cross-Linking in B Lymphocytes

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization

1988 • 1,278 citations

A Nerve Growth Factor-Induced Gene Encodes a Possible Transcriptional Regulatory Factor

1987 • 1,217 citations

Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors

1986 • 883 citations

Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5′ element and c-fos 3′ sequences

1985 • 871 citations

A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences.

1988 • 733 citations

Ternary complex factors: growth factor regulated transcriptional activators

1994 • 686 citations

Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells.

1988 • 580 citations

Activation of ternary complex factor Elk-1 by MAP kinases.

1993 • 561 citations

The ability of a ternary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoter

1989 • 495 citations

Signal Transduction by the B Cell Antigen Receptor and its Coreceptors

1994 • 419 citations

The Drosophila 74EF early puff contains E74, a complex ecdysone-inducible gene that encodes two ets-related proteins

1990 • 417 citations

Calcium and growth factor pathways of c-fos transcriptional activation require distinct upstream regulatory sequences.

1988 • 404 citations

Functional analysis of a growth factor-responsive transcription factor complex

1993 • 386 citations

The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage

1993 • 384 citations

Cloning of tetradecanoyl phorbol ester-induced 'primary response' sequences and their expression in density-arrested Swiss 3T3 cells and a TPA non-proliferative variant.

1987 • 360 citations

A novel early growth response gene rapidly induced by fibroblast, epithelial cell and lymphocyte mitogens.

1987 • 292 citations

The SRE: a growth factor responsive transcriptional regulator.

1990 • 287 citations

Distinct Protein Targets for Signals Acting at the c- fos Serum Response Element

1991 • 244 citations

Transcriptional activation and repression by Fos are independent functions: the C terminus represses immediate-early gene expression via CArG elements.

1990 • 218 citations

Ionizing radiation activates transcription of the EGR1 gene via CArG elements.

1992 • 200 citations

Sequence-specific DNA binding of the proto-oncoprotein ets-1 defines a transcriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virus.

1990 • 192 citations

Functional serum response elements upstream of the growth factor-inducible gene zif268.

1989 • 180 citations

Spatial flexibility in ternary complexes between SRF and its accessory proteins.

1992 • 175 citations

Inducible binding of a factor to the c-fos regulatory region.

1987 • 168 citations

Expression of a human placental alkaline phosphatase gene in transfected cells: use as a reporter for studies of gene expression.

1988 • 165 citations

5' flanking sequence and genomic structure of Egr-1, a murine mitogen inducible zinc finger encoding gene

1988 • 158 citations

c-fos transcriptional activation and repression correlate temporally with the phosphorylation status of TCF.

1993 • 153 citations

Activation of the inducible orphan receptor gene nur77 by serum growth factors: dissociation of immediate-early and delayed-early responses.

1993 • 138 citations

Elk-1 protein domains required for direct and SRF-assisted DNA-binding

1992 • 137 citations

Role of primary response genes in generating cellular responses to growth factors

1992 • 124 citations

5' upstream sequence and genomic structure of the human primary response gene, EGR-1/TIS8.

1991 • 112 citations

v-Src activates mitogen-responsive transcription factor Egr-1 via serum response elements

1991 • 97 citations

Granulocyte-macrophage colony-stimulating factor and interleukin-3 signaling pathways converge on the CREB-binding site in the human egr-1 promoter.

1994 • 96 citations

Ternary complex formation over the c-fos serum response element: p62TCF exhibits dual component specificity with contacts to DNA and an extended structure in the DNA-binding domain of p67SRF.

1992 • 94 citations

Differential expression of a zinc finger-encoding gene in response to positive versus negative signaling through receptor immunoglobulin in murine B lymphocytes.

1989 • 86 citations

Egr-1 expression in surface Ig-mediated B cell activation. Kinetics and association with protein kinase C activation.

1990 • 82 citations

B cell antigen receptor cross-linking triggers rapid protein kinase C independent activation of p21ras1.

1993 • 81 citations

Stimulation of B-cells via the membrane immunoglobulin receptor or with phorbol myristate 13-acetate induces tyrosine phosphorylation and activation of a 42-kDa microtubule-associated protein-2 kinase.

1991 • 75 citations

A divergent ets-related protein, elk-1, recognizes similar c-ets-1 proto-oncogene target sequences and acts as a transcriptional activator.

1992 • 62 citations

Selective activation of p42 mitogen-activated protein (MAP) kinase in murine B lymphoma cell lines by membrane immunoglobulin cross-linking. Evidence for protein kinase C-independent and -dependent mechanisms of activation

1992 • 56 citations

Epidermal growth factor and other mitogens induce binding of a protein complex to the c-fos serum response element in human astrocytoma and other cells

1991 • 54 citations

Nerve growth factor induces transcription of NGFIA through complex regulatory elements that are also sensitive to serum and phorbol 12-myristate 13-acetate.

1993 • 50 citations

Induction of CREB activity via the surface Ig receptor of B cells.

1993 • 49 citations

PDGF-induced Egr-1 expression in rat mesangial cells is mediated through upstream serum response elements

1993 • 48 citations

v-Fps-responsiveness in the Egr-1 promoter is mediated by serum response elements

1992 • 34 citations

HTLV-I and HTLV-II tax trans-activate the human EGR-1 promoter through different cis-acting sequences.

1992 • 33 citations

Transcriptional regulation of the early growth response 1 gene in human myeloid leukemia cells by okadaic acid.

1993 • 31 citations

Cross-linking of surface Ig receptors on murine B lymphocytes stimulates the expression of nuclear tetradecanoyl phorbol acetate-response element-binding proteins.

1991 • 29 citations

Evidence that activation of the Egr-1 promoter by v-Raf involves serum response elements.

1992 • 23 citations

Activation of the early growth response 1 gene and nuclear pp90rsk in human myeloid leukemia cells by 1-(.beta.-D-arabinofuranosyl)cytosine

1993 • 19 citations

Activation of early growth response 1 gene transcription and pp90rsk during induction of monocytic differentiation.

1994 • 18 citations

Transient transfection of murine B lymphocyte blasts as a method for examining gene regulation in primary B cells

1995 • 16 citations