Differentiation of an immature T cell line: A model of thymic positive selection

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).

1986 • 2,490 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells

1990 • 997 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

Mice lacking MHC class II molecules

1991 • 869 citations

Superantigens: Mechanism of T-Cell Stimulation and Role in Immune Responses

1991 • 783 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

Depletion of CD4 ⁺ T Cells in Major Histocompatibility Complex Class II-Deficient Mice

1991 • 673 citations

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

1988 • 671 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

Biological Activity of Recombinant Human Interleukin-2 Produced in Escherichia coli

1984 • 600 citations

Calcium‐activated DNA fragmentation kills immature thymocytes

1989 • 533 citations

Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes

1989 • 513 citations

Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice

1988 • 505 citations

The cell-cycle regulated proliferating cell nuclear antigen is required for SV40 DNA replication in vitro

1987 • 491 citations

The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens

1988 • 491 citations

Molecular and Cellular Events of T Cell Development

1989 • 466 citations

Cotransfection of ICAM-1 and HLA-DR reconstitutes human antigen-presenting cell function in mouse L cells

1989 • 389 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

1991 • 368 citations

Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphoid tissues

1982 • 359 citations

Kinetics of mature T-cell development in the thymus.

1990 • 331 citations

Site-Specific Mutagenesis of the Human Interleukin-2 Gene: Structure-Function Analysis of the Cysteine Residues

1984 • 328 citations

Activation events during thymic selection.

1992 • 326 citations

Residues of the variable region of the T-cell-receptor β-chain that interact with S. aureus toxin superantigens

1990 • 301 citations

Role of self-peptides in positively selecting the T-cell repertoire

1990 • 300 citations

Agents that elevate cAMP stimulate DNA fragmentation in thymocytes.

1990 • 265 citations

The Influence of Thymus H-2 Antigens on the Specificity of Maturing Killer and Helper Cells

1978 • 257 citations

Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype.

1991 • 254 citations

Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells

1991 • 249 citations

Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes

1987 • 248 citations

Characterization of murine thymocytes with CDS-associated T-cell receptor structures

1987 • 245 citations

Positive selection of the T cell repertoire: Where and when does it occur?

1989 • 242 citations

Identification of the region of T cell receptor β chain that interacts with the self-superantigen MIs-1a

1990 • 242 citations

Activation of a suicide process of thymocytes through DNA fragmentation by calcium ionophores and phorbol esters.

1989 • 242 citations

The generation of mature T cells requires interaction of the αβ T-cell receptor with major histocompatibility antigens

1989 • 219 citations

Expression and functional significance of the J11d marker on mouse thymocytes.

1987 • 218 citations

Rapid, small-scale RNA isolation from tissue culture cells.

1991 • 216 citations

The major histocompatibility complex-restricted antigen receptor on T cells: Distribution on thymus and peripheral T cells

1984 • 210 citations

Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage

1991 • 209 citations

The accessory function of murine intercellular adhesion molecule-1 in T lymphocyte activation. Contributions of adhesion and co-activation.

1991 • 197 citations

Cell Surface Antigen Expression on Thymocytes: Development and Phenotypic Differentiation of Intrathymic Subsets

1984 • 179 citations

Positive selection of CD4+ thymocytes controlled by MHC class II gene products

1988 • 174 citations

In vivo and in vitro clonal deletion of double-positive thymocytes.

1992 • 172 citations

Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding.

1990 • 170 citations

Involvement of the same region of the T cell antigen receptor in thymic selection and foreign peptide recognition.

1992 • 159 citations

CD4+ and CD8+ T cells acquire specific lymphokine secretion potentials during thymic maturation

1991 • 155 citations

Phenotypic differences between αβ versus β T-cell receptor transgenic mice undergoing negative selection

1989 • 147 citations

Development of the CD4 and CD8 lineage of T cells: instruction versus selection.

1991 • 144 citations

Lineage relationships and developmental kinetics of immature thymocytes: CD3, CD4, and CD8 acquisition in vivo and in vitro.

1990 • 143 citations

The thymus has two functionally distinct populations of immature αβ+ T cells: One population is deleted by ligation of αβTCR

1989 • 140 citations

Two Lyt-2 polypeptides arise from a single gene by alternative splicing patterns of mRNA

1985 • 135 citations

The level of CD8 expression can determine the outcome of thymic selection

1992 • 134 citations

Intrathymic maturation of murine T lymphocytes from CD8+ precursors.

1989 • 134 citations

Positive selection of CD4+ T cells mediated by MHC class ll-bearing stromal cell in the thymic cortex

1989 • 130 citations

CD8 surface levels alter the fate of alpha/beta T cell receptor-expressing thymocytes in transgenic mice.

1992 • 119 citations

Isolation of the murine intercellular adhesion molecule 1 (ICAM-1) gene. ICAM-1 enhances antigen-specific T cell activation.

1989 • 118 citations

The cell cycle block and lysis of an activated T cell hybridoma are distinct processes with different Ca2+ requirements and sensitivity to cyclosporine A.

1989 • 110 citations

Influence of the Major Histocompatibility Complex on Positive Thymic Selection of V_β17a⁺T Cells

1989 • 110 citations

The role of LFA-1/ICAM-1 interactions during murine T lymphocyte development.

1991 • 105 citations

Restricted helper function of F1 leads to parent bone marrow chimeras controlled by K-end of H-2 complex.

1978 • 96 citations

Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail

1992 • 93 citations

Thymocyte LFA-1 and thymic epithelial cell ICAM-1 molecules mediate binding of activated human thymocytes to thymic epithelial cells.

1990 • 92 citations

Presentation of antigen, foreign major histocompatibility complex proteins and self by thymus cortical epithelium

1989 • 83 citations

Positive selection of CD4-CD8+ T cells in the thymus of normal mice

1989 • 81 citations

Deletion of antigen-specific immature thymocytes by dendritic cells requires LFA-1/ICAM interactions.

1992 • 81 citations

Alpha beta T cell receptor and CD3 transduce different signals in immature T cells. Implications for selection and tolerance.

1989 • 72 citations

Clonal deletion induced by either radioresistant thymic host cells or lymphohemopoietic donor cells at different stages of class I-restricted T cell ontogeny.

1992 • 67 citations

Expression and role of the T cell receptor in early thymocyte differentiation in vitro.

1987 • 66 citations

The T cell receptor V alpha 11 gene family. Analysis of allelic sequence polymorphism and demonstration of J alpha region-dependent recognition by allele-specific antibodies.

1991 • 62 citations

Subpopulations of mature murine thymocytes: Properties of CD4−CD8+ and CD4+CD8− thymocytes lacking the heat-stable antigen

1988 • 58 citations

Phenotypic analysis of thymocytes that express homing receptors for peripheral lymph nodes.

1986 • 53 citations

The development of helper T cell precursors in mouse thymus.

1988 • 50 citations

Only dull CD3⁺ thymocytes bind to thymic epithelial cells. the binding is elicited by both CD2/LFA‐3 and LFA‐1/ICAM‐1 interactions

1989 • 46 citations

Expression of T cell antigen receptor beta-chains on subsets of mouse thymocytes. Analysis by three-color flow cytometry.

1987 • 42 citations

Formal proof that different-size Lyt-2 polypeptides arise from differential splicing and post-transcriptional regulation.

1986 • 41 citations

IL-2 receptor inducibility is blocked in cortical-type thymocytes.

1988 • 35 citations

Mouse thymic epithelial cell lines interact with and select a CD3^lowCD4⁺ CD8⁺ thymocyte subset through an LFA-1-dependent adhesion -de-adhesion mechanism

1990 • 34 citations

T cell receptor-mediated selection of functional rat CD8 T cells from defined immature thymocyte precursors in short-term suspension culture.

1991 • 30 citations

Distribution of LCA protein subspecies and the cellular adhesion molecules LFA-1, ICAM-1 and p150,95 within human foetal thymus.

1990 • 22 citations

Expression of CD1 and class I MHC antigens by human thymocytes.

1989 • 21 citations

Only dull CD3[+] thymocytes bind to thymic epithelial cells

1989 • 6 citations