Growth stimulation of primary rat hepatocytes by 2,3,7,8-tetrachlorodibenzo-p-dioxin

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

1982 • 2,512 citations

Ethoxyresorufin: direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene.

1974 • 1,562 citations

Increased cell division as a cause of human cancer.

1990 • 894 citations

Biologically active phorbol esters specifically alter affinity of epidermal growth factor membrane receptors

1979 • 517 citations

The stages of initiation and promotion in hepatocarcinogenesis

1980 • 515 citations

[The role of protein kinase C in cell surface signal transduction and tumor promotion].

1986 • 508 citations

Genetic and Molecular Aspects of 2,3,7,8-Tetra-Chlorodibenzo-P-Dioxin Action

1990 • 446 citations

Quantitative evaluation of the promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin of hepatocarcinogenesis from diethylnitrosamine.

1980 • 374 citations

Cellular biochemistry of the stepwise development of cancer with chemicals: G. H. A. Clowes memorial lecture.

1984 • 363 citations

Hormonal stimulation of DNA synthesis in primary cultures of adult rat hepatocytes.

1976 • 359 citations

Chlorinated biphenyl induction of aryl hydrocarbon hydroxylase activity: a study of the structure-activity relationship.

1977 • 347 citations

Inhibitory effect of transforming growth factor-β on DNA synthesis of adult rat hepatocytes in primary culture

1985 • 325 citations

Tumour promotion by TCDD in skin of HRS/J hairless mice

1982 • 293 citations

Control of Cytochrome P ₁ -450 Gene Expression by Dioxin

1985 • 272 citations

Receptor-mediated endocytosis of epidermal growth factor by hepatocytes in the perfused rat liver: ligand and receptor dynamics.

1984 • 265 citations

Tumor promotion in the liver

1985 • 258 citations

A Transplantable Bile-Secreting Hepatocellular Carcinoma in the Rat<xref ref-type="fn" rid="FN1">2</xref><xref ref-type="fn" rid="FN2">3</xref>

1961 • 248 citations

A method to quantitate the relative initiating and promoting potencies of hepatocarcinogenic agents in their dose-response relationships to altered hepatic foci

1987 • 197 citations

Enhanced proliferation of putative preneoplastic cells in rat liver following treatment with the tumor promoters phenobarbital, hexachlorocyclohexane, steroid compounds, and nafenopin.

1981 • 193 citations

Oxidative stress induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

1990 • 192 citations

Neutral red (NR) assay for cell viability and xenobiotic-induced cytotoxicity in primary cultures of human and rat hepatocytes

1990 • 166 citations

Effects of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on receptor binding of epidermal growth factor in the hepatic plasma membrane of rat, guinea pig, mouse, and hamster.

1984 • 164 citations

Ovarian hormones enhance 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated increases in cell proliferation and preneoplastic foci in a two-stage model for rat hepatocarcinogenesis.

1991 • 148 citations

Use of primary cultures of adult rat hepatocytes to investigate mechanisms of action of nafenopin, a hepatocarcinogenic peroxisome proliferator

1984 • 90 citations

Unscheduled DNA synthesis induced by procarcinogens in suspensions and primary cultures of hepatocytes on collagen membranes.

1978 • 90 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin: Failure to demonstrate toxicity in twenty-three cultured cell types

1980 • 88 citations

TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) causes increases in protein kinases particularly protein kinase C in the hepatic plasma membrane of the rat and the guinea pig

1985 • 87 citations

Tumor promoters : biological approaches for mechanistic studies and assay systems

1988 • 85 citations

Stimulation of DNA synthesis in rat and mouse liver by various tumor promoters

1987 • 83 citations

Hydroxyanthraquinones as tumor promoters: enhancement of malignant transformation of C3H mouse fibroblasts and growth stimulation of primary rat hepatocytes.

1990 • 72 citations

Polyhalogenated dibenzo-p-dioxins and dibenzofurans and the immune system

1991 • 71 citations

Effects of the liver tumor promoter ethinyl estradiol on epidermal growth factor-induced DNA synthesis and epidermal growth factor receptor levels in cultured rat hepatocytes.

1989 • 52 citations

Aryl hydrocarbon (Ah) receptor DNA-binding activity. Sequence specificity and Zn2+ requirement.

1990 • 49 citations

GROWTH CONTROL OF DIFFERENTIATED FETAL RAT HEPATOCYTES IN PRIMARY MONOLAYER CULTURE

1974 • 46 citations

Insulin Receptor Regulation and Desensitization in Rat Hepatoma Cells: Concomitant Changes in Receptor Number and in Binding Affinity

1984 • 43 citations

Relative toxicity and tumor-promoting ability of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,4,7,8-pentachlorodibenzofuran (PCDF), and 1,2,3,4,7,8-hexachlorodibenzofuran (HCDF) in hairless mice

1990 • 43 citations

Suppression of Liver Cell Proliferation by Glucocorticoid Hormone: A Comparison of Normally Growing and Regenerating Tissue in the Immature Rat*

1978 • 38 citations

The Glucagon-Insulin Antagonism and Glucagon-Dexamethasone Synergism in the Induction of Phosphoenolpyruvate Carboxykinase in Cultured Rat Hepatocytes

1983 • 37 citations

Abnormal insulin-receptor down regulation and dissociation of down regulation from insulin biological action in cultured human tumor cells.

1987 • 33 citations

Stimulation of DNA synthesis in primary rat hepatocyte cultures by liver tumor promoters: interactions with other growth factors

1990 • 32 citations

Phenobarbital and some other liver tumor promoters stimulate DNA synthesis in cultured rat hepatocytes

1985 • 32 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) enhances antibody production and protein kinase activity in murine B cells

1987 • 31 citations

Different response to epidermal growth factor of hepatocytes in cultures isolated from male or female rat liver

1987 • 28 citations

Altered growth control of rat hepatocytes after treatment with 3,4,3′,4′-tetrachlorobiphenylin vivo and in vitro

1988 • 27 citations

Dexamethasone-mediated potentiation of P450IA1 induction in H4IIEC3/T hepatoma cells is dependent on a time-consuming process and associated with induction of the Ah receptor

1990 • 22 citations

Culture duration alters the glutathione content and sensitivity to ethacrynic acid of rat hepatocyte monolayer cultures

1986 • 16 citations

Zinc increases egf-stimulated dna synthesis in primary mouse hepatocytes

1990 • 14 citations

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on [3H] thymidine incorporation into rat liver deoxyribonucleic acid

1983 • 12 citations

Resistance to the cytocidal effects of adriamycin is an early phenotypic change induced during hepatocarcinogenesis

1981 • 10 citations

The effects of TCDD on receptors for epidermal growth factor, glucocorticoid, and estrogen in Ah-responsive and -nonresponsive congenic mice and the effects of TCDD on estradiol metabolism in a liver tumor promotion model in female rats.

1990 • 8 citations

Characterization of 3-methylcholanthrene effects on the rat glucocorticoid receptor in vivo.

1989 • 7 citations

Selection of medium for serum-free primary culture of adult rat hepatocytes.

1990 • 3 citations

[Characterization of cytosol and nuclear glucocorticoid receptors from rat liver tissue in hepatocarcinogenesis].

1983 • 2 citations