Histone–GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells

Green Fluorescent Protein as a Marker for Gene Expression

1994 • 6,572 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

pEF-BOS, a powerful mammalian expression vector

1990 • 1,641 citations

Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells.

1993 • 1,395 citations

Understanding, improving and using green fluorescent proteins

1995 • 1,350 citations

Chromatin Structure and Function

1979 • 1,050 citations

Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma.

1983 • 764 citations

The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses

1996 • 728 citations

In vivo localization of DNA sequences and visualization of large-scale chromatin organization using lac operator/repressor recognition.

1996 • 709 citations

GFP tagging of budding yeast chromosomes reveals that protein–protein interactions can mediate sister chromatid cohesion

1996 • 589 citations

GENE AMPLIFICATION

1984 • 580 citations

Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector

1997 • 499 citations

Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere.

1994 • 444 citations

Optimized Codon Usage and Chromophore Mutations Provide Enhanced Sensitivity with the Green Fluorescent Protein

1996 • 435 citations

Expression of Fragile Sites Triggers Intrachromosomal Mammalian Gene Amplification and Sets Boundaries to Early Amplicons

1997 • 399 citations

Role of Nucleosomal Cores and Histone H1 in Regulation of Transcription by RNA Polymerase II

1991 • 379 citations

DOUBLE MINUTES AND HOMOGENEOUSLY STAINING REGIONS: Gene Amplification in Mammalian Cells

1982 • 357 citations

Applications of the green fluorescent protein in cell biology and biotechnology

1997 • 354 citations

Visualization of G1 chromosomes: a folded, twisted, supercoiled chromonema model of interphase chromatid structure.

1994 • 331 citations

Green fluorescent protein: applications in cell biology

1996 • 252 citations

Dynamic elastic behavior of alpha-satellite DNA domains visualized in situ in living human cells.

1996 • 204 citations

Role of nucleosomal cores and histone H1 in regulation of transcription by RNA polymerase II

1991 • 204 citations

Large-scale chromatin structural domains within mitotic and interphase chromosomes in vivo and in vitro

1989 • 194 citations

Chapter 16 Fluorescence Labeling and Microscopy of DNA

1989 • 186 citations

Chromatin structure and function

1994 • 180 citations

Elimination of extrachromosomally amplified MYC genes from human tumor cells reduces their tumorigenicity.

1992 • 175 citations

A yeast RNA-binding protein shuttles between the nucleus and the cytoplasm.

1994 • 164 citations

Distribution of kinetochore (centromere) antigen in mammalian cell nuclei.

1981 • 147 citations

Compilation analysis of histones and histone genes

1986 • 141 citations

Double minute chromosomes and homogeneously staining regions in tumors taken directly from patients versus in human tumor cell lines

1991 • 130 citations

Blasticidin S-resistance gene (bsr): A novel selectable marker for mammalian cells

1991 • 122 citations

The primary structure and expression of four cloned human histone genes

1983 • 120 citations

Have double minutes functioning centromeres?

2009 • 117 citations

Focal points for chromosome condensation and decondensation revealed by three-dimensional in vivo time-lapse microscopy

1989 • 112 citations

Direct cell lineage analysis in Drosophila melanogaster by time-lapse, three-dimensional optical microscopy of living embryos.

1989 • 102 citations

Selective capture of acentric fragments by micronuclei provides a rapid method for purifying extrachromosomally amplified DNA

1996 • 75 citations

Cell cycle synchronization: reversible induction of G2 synchrony in cultured rodent and human diploid fibroblasts.

1990 • 69 citations

A Yeast RNA-Binding Protein Shuttles between the Nucleus and the Cytoplasm

1994 • 69 citations

Nuclear distribution of centromeres during the cell cycle of human diploid fibroblasts

1991 • 60 citations

Are double minutes chromosomes?

1978 • 49 citations

Mitotic and post mitotic consequences of genomic instability induced by oncogenic Ha-Ras

1995 • 45 citations

Riding the polar winds: Chromosomes motor down East

1995 • 41 citations

Hamster chromosomes containing amplified human α-satellite DNA show delayed sister chromatid separation in the absence of de novo kinetochore formation

1997 • 37 citations

Fluorescence imaging of mammalian living cells

1996 • 15 citations