Immunohistochemical and genetic evidence of myeloperoxidase involvement in multiple sclerosis

The Future of Genetic Studies of Complex Human Diseases

1996 • 5,355 citations

Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

1995 • 1,528 citations

Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions.

1994 • 1,274 citations

Multiple Sclerosis: A Coordinated Immunological Attack against Myelin in the Central Nervous System

1996 • 903 citations

Oxygen Metabolism and the Toxic Properties of Phagocytes

1980 • 886 citations

THE DEVELOPMENT OF NEUTROPHILIC POLYMORPHONUCLEAR LEUKOCYTES IN HUMAN BONE MARROW

1971 • 870 citations

Altered Reactivity of Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis

1996 • 718 citations

A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex

1996 • 650 citations

A genetic basis for familial aggregation in multiple sclerosis

1995 • 626 citations

Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions.

1995 • 473 citations

Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis.

1995 • 464 citations

An Alu Element in the Myeloperoxidase Promoter Contains a Composite SP1-Thyroid Hormone-Retinoic Acid Response Element

1996 • 415 citations

Inhibition of Amyloid β Protein Aggregation and Neurotoxicity by Rifampicin

1996 • 288 citations

Spin trapping evidence for myeloperoxidase-dependent hydroxyl radical formation by human neutrophils and monocytes.

1992 • 233 citations

Identification of a New Subclass of Alu DNA Repeats Which Can Function as Estrogen Receptor-dependent Transcriptional Enhancers

1995 • 226 citations

Molecular Chlorine Generated by the Myeloperoxidase-Hydrogen Peroxide-Chloride System of Phagocytes Converts Low Density Lipoprotein Cholesterol into a Family of Chlorinated Sterols

1996 • 219 citations

Comparison of phenotypic and functional properties of immediately ex vivo and cultured human adult microglia

1996 • 217 citations

Expression of the neutrophil elastase gene during human bone marrow cell differentiation.

1989 • 190 citations

Oxygen radicals as key mediators in neurological disease: Fact or fiction?

1992 • 186 citations

Myeloperoxidase: its structure and expression during myeloid differentiation

1985 • 184 citations

The consensus sequence of a major Alu subfamily contains a functional retinoic acid response element.

1995 • 176 citations

Characterization of cDNA clones for human myeloperoxidase: Predicted amino acid sequence and evidence for multiple mRNA species

1987 • 169 citations

An Allelic Association Implicates Myeloperoxidase in the Etiology of Acute Promyelocytic Leukemia

1997 • 166 citations

Phenotypic Differences between Human Monocytes/Macrophages and Microglial Cells StudiedIn SituandIn Vitro

1994 • 118 citations

Myelin basic protein and human coronavirus 229E cross‐reactive T cells in multiple sclerosis

1996 • 117 citations

Biochemical and Immunologic Analysis of Hereditary Myeloperoxidase Deficiency

1983 • 115 citations

Regulation of gene expression of myeloperoxidase during myeloid differentiation

1988 • 110 citations

Disturbed myeloperoxidase-dependent activity of neutrophils in cystic fibrosis homozygotes and heterozygotes, and its correction by amiloride.

1996 • 102 citations

Myeloperoxidase-enhanced formation of (±)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a] pyrene adducts in lung tissue in vitro: a role of pulmonary inflammation in the bioactivation of a procarcinogen

1992 • 102 citations

Hypochlorous acid/N-chloramines are naturally produced DNA repair inhibitors

1996 • 87 citations

Regulation of CD14 expression on human adult central nervous system-derived microglia

1996 • 82 citations

Regulation of myeloperoxidase gene expression during differentiation of human myeloid leukemia HL-60 cells.

1984 • 78 citations

The role of peroxidase-catalyzed activation of aromatic amines in breast cancer

1996 • 77 citations

Effect of the R569W Missense Mutation on the Biosynthesis of Myeloperoxidase

1996 • 75 citations

Herpes Simplex Virus in Postmortem Multiple Sclerosis Brain Tissue

1996 • 71 citations

Culture of Glial Cells from Human Brain Biopsies

1997 • 70 citations

Hypochlorous acid potentiates hydrogen peroxide-mediated DNA-strand breaks in human mononuclear leucocytes

1992 • 57 citations

Evolutionary selection against change in many Alu repeat sequences interspersed through primate genomes.

1994 • 54 citations

Major T-cell responses in multiple sclerosis

1995 • 52 citations

Increased generation of superoxide radicals in the blood of MS patients

2009 • 48 citations

On classification of post-mortem multiple sclerosis plaques for neuroscientists

1993 • 47 citations

Results of a phase I clinical trial of a T-cell receptor peptide vaccine in patients with multiple sclerosis. I. Analysis of T-cell receptor utilization in CSF cell populations

1997 • 45 citations

Human myeloperoxidase gene expression in acute leukemia

1989 • 40 citations

Human myeloperoxidase gene expression in acute leukemia

1989 • 37 citations

An Allelic Association Implicates Myeloperoxidase in the Etiology of Acute Promyelocytic Leukemia

1997 • 24 citations