Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Beyond Cholesterol

1989 • 6,533 citations

The Pathogenesis of Atherosclerosis — An Update

1986 • 4,951 citations

Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT

1973 • 2,955 citations

Oxygen-Dependent Microbial Killing by Phagocytes

1978 • 2,519 citations

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition

1979 • 2,458 citations

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

1989 • 1,914 citations

Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.

1984 • 1,631 citations

Low density lipoprotein undergoes oxidative modification in vivo.

1989 • 1,537 citations

Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells.

1990 • 1,147 citations

Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.

1987 • 1,051 citations

Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins.

1981 • 1,037 citations

Minimally modified low density lipoprotein stimulates monocyte endothelial interactions.

1990 • 930 citations

Studies on the chlorinating activity of myeloperoxidase.

1976 • 918 citations

Oxygen Metabolism and the Toxic Properties of Phagocytes

1980 • 886 citations

Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia.

1987 • 885 citations

Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation.

1984 • 826 citations

Malondialdehyde-Altered Protein Occurs in Atheroma of Watanabe Heritable Hyperlipidemic Rabbits

1988 • 757 citations

The neutrophil: Function and clinical disorders

1978 • 670 citations

The neutrophil: Function and clinical disorders

1979 • 628 citations

Oxidation of human low density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxide decomposition products.

1987 • 625 citations

Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture.

1984 • 547 citations

Monocytes and Neutrophils Oxidize Low Density Lipoprotein Making It Cytotoxic

1985 • 536 citations

Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells.

1986 • 516 citations

Dityrosine, a specific marker of oxidation, is synthesized by the myeloperoxidase-hydrogen peroxide system of human neutrophils and macrophages.

1993 • 486 citations

Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits.

1990 • 478 citations

The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells.

1987 • 465 citations

Oxygen-Dependent Microbial Killing by Phagocytes

1978 • 448 citations

Biological reactivity of hypochlorous acid: implications for microbicidal mechanisms of leukocyte myeloperoxidase.

1981 • 443 citations

Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions.

1990 • 429 citations

HHF35, a muscle-actin-specific monoclonal antibody. I. Immunocytochemical and biochemical characterization.

1987 • 427 citations

A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein.

1989 • 417 citations

Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptor.

1986 • 417 citations

Cell biology of arterial proteoglycans.

1989 • 409 citations

Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase.

1992 • 382 citations

Hydrogen peroxide metabolism in human monocytes during differentiation in vitro.

1981 • 361 citations

Tyrosyl radical generated by myeloperoxidase catalyzes the oxidative cross-linking of proteins.

1993 • 345 citations

Oxidation of low-density lipoprotein with hypochlorite causes transformation of the lipoprotein into a high-uptake form for macrophages

1993 • 311 citations

Specificity of receptor-mediated recognition of malondialdehyde-modified low density lipoproteins.

1982 • 279 citations

Superoxide initiates oxidation of low density lipoprotein by human monocytes.

1987 • 273 citations

Intracellular singlet oxygen generation by phagocytosing neutrophils in response to particles coated with a chemical trap.

1992 • 259 citations

Chlorohydrin formation from unsaturated fatty acids reacted with hypochlorous acid

1992 • 255 citations

Direct evidence for a protein recognized by a monoclonal antibody against oxidatively modified LDL in atherosclerotic lesions from a Watanabe heritable hyperlipidemic rabbit.

1989 • 250 citations

Induction of T-cell activation by oxidized low density lipoprotein.

1992 • 246 citations

Characterization and quantification of the peroxidase in human monocytes

1978 • 238 citations

Spin trapping evidence for myeloperoxidase-dependent hydroxyl radical formation by human neutrophils and monocytes.

1992 • 233 citations

Role of superoxide in endothelial-cell modification of low-density lipoproteins

1988 • 228 citations

Minimally oxidized low-density lipoprotein induces tissue factor expression in cultured human endothelial cells.

1991 • 228 citations

Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages

1991 • 223 citations

[52] Antimicrobial activity of myeloperoxidase

1984 • 208 citations

Low density lipoprotein is protected from oxidation and the progression of atherosclerosis is slowed in cholesterol-fed rabbits by the antioxidant N,N'-diphenyl-phenylenediamine.

1992 • 207 citations

Phagocytosis of aggregated lipoprotein by macrophages: low density lipoprotein receptor-dependent foam-cell formation.

1989 • 200 citations

The reductive cleavage of myeloperoxidase in half, producing enzymically active hemi-myeloperoxidase.

1981 • 196 citations

Isolation procedure and some properties of myeloperoxidase from human leucocytes

1978 • 190 citations

Lipid Peroxidation by Human Blood Phagocytes

1974 • 177 citations

Myeloperoxidase of Human Leukaemic Leucocytes

1968 • 165 citations

A human macrophage‐associated antigen (CD68) detected by six different monoclonal antibodies

1989 • 162 citations

Cellular oxidation of low density lipoprotein is caused by thiol production in media containing transition metal ions

1993 • 159 citations

Probucol attenuates the development of aortic atherosclerosis in cholesterol‐fed rabbits

1989 • 142 citations

Isolation of low density lipoprotein from atherosclerotic vascular tissue of Watanabe heritable hyperlipidemic rabbits.

1988 • 135 citations

Clearance of Neutrophil-derived Myeloperoxidase by the Macrophage Mannose Receptor

1990 • 134 citations

Myeloperoxidase-catalyzed incorporation of amines into proteins: role of hypochlorous acid and dichloramines

1982 • 132 citations

Oxidative tyrosylation of high density lipoprotein by peroxidase enhances cholesterol removal from cultured fibroblasts and macrophage foam cells.

1993 • 128 citations

CD antigens 1989

1989 • 102 citations

Cellular oxidative modification of low density lipoprotein does not require lipoxygenases.

1992 • 101 citations

Myeloperoxidase Deficiency

1988 • 99 citations

The effects of probucol on the progression of atherosclerosis in mature Watanabe heritable hyperlipidaemic rabbits

1991 • 93 citations

The subunit structure of crystalline canine myeloperoxidase

1977 • 92 citations

Possible involvement of myeloperoxidase in lipid peroxidation

1992 • 88 citations

Human eosinophil peroxidase: a novel isolation procedure, spectral properties and chlorinating activity

1981 • 82 citations

5-Lipoxygenase is not essential in macrophage-mediated oxidation of low-density lipoprotein

1991 • 69 citations

Crystallization and Properties of Myeloperoxidase from Normal Human Leukocytes

1986 • 61 citations

Oxidant membrane injury by the neutrophil myeloperoxidase system. II. Injury by stimulated neutrophils and protection by lipid-soluble antioxidants.

1985 • 48 citations

Evidence for and partial characterization of three major and three minor chromatographic forms of human neutrophil myeloperoxidase

1986 • 41 citations

Unique autolytic cleavage of human myeloperoxidase. Implications for the involvement of active site MET409.

1992 • 40 citations

Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptor.

1986 • 36 citations

Peroxidatic activity in monocytes and tissue macrophages of mice

1978 • 34 citations

Myeloperoxidase: Localization, Structure, and Function

1991 • 34 citations

Modification of low density lipoproteins by sodium hypochlorite.

1991 • 33 citations

Loss of Granule Myeloperoxidase during in Vitro Culture of Human Monocytes Correlates with Decay in Antiprotozoa Activity

1987 • 30 citations

Myeloperoxidase deficiency

2011 • 26 citations

Myeloperoxidase-mediated inhibition of microbial respiration: damage to Escherichia coli ubiquinol oxidase

1989 • 13 citations

Deleted Work

1955 • 0 citations