Major T-cell responses in multiple sclerosis

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

1988 • 940 citations

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1990 • 906 citations

Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.

1994 • 539 citations

Selection for T-cell receptor Vβ–Dβ–Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis

1993 • 400 citations

Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy

1989 • 394 citations

Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals.

1990 • 342 citations

Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones.

1994 • 323 citations

MHC-Restricted Depletion of Human Myelin Basic Protein-Reactive T Cells by T Cell Vaccination

1993 • 286 citations

Amelioration of Autoimmune Encephalomyelitis by Myelin Basic Protein Synthetic Peptide-Induced Anergy

1992 • 251 citations

Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon gamma and tumor necrosis factor alpha production.

1994 • 216 citations

Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients.

1993 • 196 citations

Ligand motifs of HLA-DRB5*0101 and DRB1*1501 molecules delineated from self-peptides.

1994 • 179 citations

Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones.

1993 • 145 citations

Oligodendrocyte-specific expression and autoantigenicity of transaldolase in multiple sclerosis.

1994 • 132 citations

Exploration of requirements for peptide binding to HLA DRB1*0101 and DRB1*0401.

1994 • 127 citations

Increased numbers of T cells recognizing multiple myelin basic protein epitopes in multiple sclerosis

1992 • 117 citations

Anti‐myelin basic protein and anti‐proteolipid protein specific forms of multiple sclerosis

1994 • 107 citations

Escape from “horror autotoxicus”: Pathogenesis and treatment of autoimmune disease

1995 • 100 citations

Predominant and stable T cell responses to regions of myelin basic protein can be detected in individual patients with multiple sclerosis

1993 • 66 citations

Genetic Factors in Multiple Sclerosis

1993 • 64 citations

Immunology of multiple sclerosis.

1992 • 64 citations

The T‐cell response to myelin basic protein in familial multiple sclerosis: Diversity of fine specificity, restricting elements, and T‐cell receptor usage

1993 • 59 citations

Myelin basic protein‐specific T‐cell responses in identical twins discordant or concordant for multiple sclerosis

1993 • 51 citations

Cells producing antibodies specific for myelin basic protein region 70–89 are predominant in cerebrospinal fluid from patients with multiple sclerosis

1991 • 35 citations

Inhibition of experimental autoimmune encephalomyelitis by MHC class II binding competitor peptides depends on the relative MHC binding affinity of the disease-inducing peptide.

1994 • 25 citations