Translocations into human chromosome 14 JH region: factors influencing downstream abortive immunoglobulin class switching

The t(14;18) Chromosome Translocations Involved in B-Cell Neoplasms Result from Mistakes in VDJ Joining

1985 • 1,021 citations

Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli

1989 • 989 citations

Cellular Origin of Human B-Cell Lymphomas

1999 • 718 citations

Mechanisms of chromosomal translocations in B cell lymphomas

2001 • 623 citations

Molecular Mechanism of Class Switch Recombination: Linkage with Somatic Hypermutation

2002 • 583 citations

Mutation ofBCL-6Gene in Normal B Cells by the Process of Somatic Hypermutation of Ig Genes

1998 • 536 citations

Somatic Hypermutation of Immunoglobulin Genes Is Linked to Transcription Initiation

1996 • 424 citations

Mechanism and control of class-switch recombination

2002 • 379 citations

Somatic hypermutation in normal and transformed human B cells

1998 • 351 citations

Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease

1998 • 347 citations

Evidence for a Large Compartment of IgM-Expressing Memory B Cells in Humans

1997 • 329 citations

The AID enzyme induces class switch recombination in fibroblasts

2002 • 267 citations

Somatic Hypermutation in the Heavy Chain Locus Correlates with Transcription

1998 • 265 citations

Switch Transcripts in Immunoglobulin Class Switching

1995 • 248 citations

Different regions of the immunoglobulin heavy-chain locus are involved in chromosomal translocations in distinct pathogenetic forms of Burkitt lymphoma.

1988 • 245 citations

Mechanism of the t(14;18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners.

1987 • 236 citations

CD40 Ligand and Appropriate Cytokines Induce Switching to IgG, IgA, and IgE and Coordinated Germinal Center and Plasmacytoid Phenotypic Differentiation in a Human Monoclonal IgM+IgD+ B Cell Line

1998 • 212 citations

Molecular Processes that Regulate Class Switching

2000 • 202 citations

The t(8; 14) chromosomal translocation occurring in B-cell malignancies results from mistakes in V–D–J joining

1986 • 184 citations

Processing of Switch Transcripts Is Required for Targeting of Antibody Class Switch Recombination

1998 • 146 citations

Translocation of the myc cellular oncogene to the immunoglobulin heavy chain locus in murine plasmacytomas is an imprecise reciprocal exchange

1984 • 128 citations

Memory, but not naive, peripheral blood B lymphocytes differentiate into Ig-secreting cells after CD40 ligation and costimulation with IL-4 and the differentiation factors IL-2, IL-10, and IL-3.

1997 • 118 citations

The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially

2001 • 106 citations

Direct sequence analysis of the 14q+ and 18q- chromosome junctions in follicular lymphoma

1990 • 85 citations

Transcriptional activation of immunoglobulin α heavy-chain genes by translocation of the c-myc oncogene

1983 • 84 citations

DNA Fiber Fluorescence In Situ Hybridization Analysis of Immunoglobulin Class Switching in B-Cell Neoplasia: Aberrant CH Gene Rearrangements in Follicle Center-Cell Lymphoma

1998 • 82 citations

Quantitation of immunoglobulin mu-gamma 1 heavy chain switch region recombination by a digestion-circularization polymerase chain reaction method.

1992 • 80 citations

DNA Fiber Fluorescence In Situ Hybridization Analysis of Immunoglobulin Class Switching in B-Cell Neoplasia: Aberrant CH Gene Rearrangements in Follicle Center-Cell Lymphoma

1998 • 76 citations

V gene rearrangement is required to fully activate the hypermutation mechanism in B cells.

1989 • 64 citations

Improved Long-Distance Polymerase Chain Reaction for the Detection of t(8;14)(q24;q32) in Burkitt's Lymphomas

1999 • 58 citations

Localization of breakpoints by polymerase chain reactions in Burkitt's lymphoma with 8;14 translocations

1990 • 53 citations

BCL8 , a novel gene involved in translocations affecting band 15q11–13 in diffuse large-cell lymphoma

1997 • 48 citations

Measles Virus Infection Synergizes with IL-4 in IgE Class Switching

1999 • 45 citations

The Ig heavy chain intronic enhancer core region is necessary and sufficient to promote efficient class switch recombination

1999 • 44 citations

An antisense promoter of the murine c-myc gene is localized within intron 2.

1992 • 43 citations

Direct sequence analysis of the t(14;18) chromosomal translocation in Hodgkin's disease

1992 • 31 citations

Normal Isotype Switching in B Cells Lacking the Iμ Exon Splice Donor Site: Evidence for Multiple Iμ-Like Germline Transcripts

2000 • 28 citations

IL-4-dependent IgE switch in membrane IgA-positive human B cells.

1991 • 26 citations

Anti-IgM induces transforming growth factor-beta sensitivity in a human B-lymphoma cell line: inhibition of growth is associated with a downregulation of mutant p53

1995 • 26 citations

CD40 ligand exerts differential effects on the expression of I gamma transcripts in subclones of an IgM+ human B cell lymphoma line.

1998 • 24 citations

CD40 Ligand Exerts Differential Effects on the Expression of Iγ Transcripts in Subclones of an IgM+ Human B Cell Lymphoma Line

1998 • 22 citations

Tracking membrane and secretory immunoglobulin α heavy chain mRNA variation during B‐cell differentiation by real‐time quantitative polymerase chain reaction

2001 • 22 citations

Myc oncogene activation in B and T lymphoid tumours

1985 • 21 citations

A submicroscopic interstitial deletion of chromosome 14 frequently occurs adjacent to the t(14;18) translocation breakpoint in human follicular lymphoma

1993 • 20 citations

Class switch recombination of the immunoglobulin heavy chain gene frequently occurs in B-cell lymphomas associated with rearrangement of the BCL2 gene.

1995 • 19 citations

Human low molecular weight B cell growth factor induces surface IgM+/A- B cells to express and secrete IgA.

1992 • 14 citations

The Ig Heavy Chain 3′ End Confers a Posttranscriptional Processing Advantage to Bcl-2–IgH Fusion RNA in t(14;18) Lymphoma

1998 • 12 citations

V‐Region and Class Specific RT‐PCR Amplification of Human Immunoglobulin Heavy and Light Chain Genes from B‐Cell Lines

1995 • 12 citations

Quantifiable analysis of human immunoglobulin heavy chain class-switch recombination to all isotypes

2000 • 11 citations

Inherent properties of somatic hypermutation as revealed by human non‐productive V_H6 immunoglobulin rearrangements

1998 • 11 citations

Lineage and stage specificity of isotype switching in humans.

1988 • 9 citations

Low-molecular-weight (61K) mu chain in P3HR-1 cells and various derived somatic hybrids

1983 • 1 citations