Strain dependency of B and T lymphoma development in immunoglobulin heavy chain enhancer (E mu)-myc transgenic mice.

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1985 • 1,782 citations

Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.

1982 • 1,746 citations

Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis

1981 • 1,611 citations

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH

1980 • 872 citations

Sequences at the somatic recombination sites of immunoglobulin light-chain genes

1979 • 859 citations

Translocations Among Antibody Genes in Human Cancer

1983 • 736 citations

Cell-type specificity of iminunoglobulin gene expression is regulated by at least three DNA sequence elements

1985 • 588 citations

Predisposition to lymphomagenesis in pim-1 transgenic mice: Cooperation with c-myc and N-myc in murine leukemia virus-induced tumors

1989 • 497 citations

The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice

1986 • 441 citations

Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumours.

1983 • 436 citations

Leukemogenic Activity of Filtrates from Radiation-Induced Lymphoid Tumors of Mice

1959 • 369 citations

Introduction of a μ immunoglobulin gene into the mouse germ line: Specific expression in lymphoid cells and synthesis of functional antibody

1984 • 304 citations

The structure, rearrangement and expression of Dβ gene segments of the murine T-cell antigen receptor

1984 • 290 citations

The Genetic Mapping of a Defective Lps Response Gene in C3H/HeJ Mice

1978 • 284 citations

Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus

1984 • 274 citations

Differential expression of the normal and of the translocated human c-myc oncogenes in B cells.

1983 • 262 citations

Effect of somatic mutation within translocated c-myc genes in Burkitt's lymphoma

1984 • 259 citations

Transcriptionally active c- myc oncogene is contained within NIARD, a DNA sequence associated with chromosome translocations in B-cell neoplasia

1983 • 236 citations

Posttranscriptional mechanisms are responsible for accumulation of truncated c-myc RNAs in murine plasma cell tumors

1985 • 227 citations

Delimitation and properties of DNA sequence: required for the regulated expression of human interferon-β gene

1985 • 216 citations

Dissecting Multistep Tumorigenesis in Transgenic Mice

1988 • 215 citations

Activation of the c-myc gene by translocation: a model for translational control.

1983 • 196 citations

Nucleotide sequence analysis of the chicken c-myc gene reveals homologous and unique coding regions by comparison with the transforming gene of avian myelocytomatosis virus MC29, delta gag-myc.

1983 • 187 citations

Nucleotide sequence to the v-myc oncogene of avian retrovirus MC29.

1983 • 184 citations

Hemopoietic lineage switch: v-raf oncogene converts Eμmyc transgenic B cells into macrophages

1988 • 179 citations

Truncation of exon 1 from the c-myc gene results in prolonged c-myc mRNa stability.

1985 • 172 citations

Infection of eucaryotic cells by helper-independent recombinant adenoviruses: early region 1 is not obligatory for integration of viral DNA

1984 • 170 citations

Aberrant c-myc RNAs of Burkitt's lymphoma cells have longer half-lives.

1985 • 152 citations

Driven by the same Ig enhancer and SV40 T promoter ras induced lung adenomatous tumors, myc induced pre-B cell lymphomas and SV40 large T gene a variety of tumors in transgenic mice.

1987 • 129 citations

Cell type-specific transcriptional enhancement in vitro requires the presence of trans-acting factors.

1985 • 127 citations

Transgenic mice bearing the human c-myc gene activated by an immunoglobulin enhancer: a pre-B-cell lymphoma model.

1988 • 118 citations

Transcriptional activation of the translocated c-myc oncogene in mouse plasmacytomas: Similar RNA levels in tumor and proliferating normal cells

1984 • 116 citations

Proviral deletions and oncogene base-substitutions in insertionally mutagenized c-myc alleles may contribute to the progression of avian bursal tumors.

1984 • 111 citations

Differential efficiencies of in vitro translation of mouse c-myc transcripts differing in the 5' untranslated region.

1985 • 104 citations

Genetic control of B cell activation by bacterial lipopolysaccharide is mediated by multiple distinct genes or alleles.

1976 • 89 citations

Indirect induction of lymphomas in irradiated mice. IV. Genetic evidence of the origin of the tumor cells from the thymic grafts.

1956 • 79 citations

A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice

1988 • 75 citations

Expression of the c-myc oncogene under control of an immunoglobulin enhancer in E mu-myc transgenic mice.

1987 • 69 citations

DNA sequences near the site of reciprocal recombination between a c-myc oncogene and an immunoglobulin switch region.

1983 • 63 citations

Indirect induction of lymphomas in irradiated mice. I. Tumor incidence and morphology in mice bearing nonirradiated thymic grafts.

1956 • 61 citations

Development of Lymphoid Tumors in Nonirradiated Thymic Grafts in Thymectomized Irradiated Mice

1954 • 49 citations

Cell lineage specificity of chromatin configuration around the immunoglobulin heavy chain enhancer.

1988 • 35 citations

The c-myc oncogene is translocated to the involved chromosome 12 in mouse plasmacytoma.

1985 • 30 citations

Induction of malignant transformation of cocultivated hematopoietic stem cells by X-irradiation of murine bone marrow stromal cells in vitro.

1986 • 26 citations

Molecular evidence that SJL reticulum cell sarcomas are derived from pre-B cell. Clonal rearrangement of heavy chain but not of light chain immunoglobulin genes.

1987 • 25 citations

Indirect induction of radiation lymphomas in mice. Evidence for a novel, transmissible leukemogen.

1987 • 21 citations

Expression of the c-myc Oncogene under Control of an Immunoglobulin Enhancer in Eµ-myc Transgenic Mice

1987 • 15 citations