Association between calnexin and a secretion-incompetent variant of human alpha 1-antitrypsin.

Protein folding in the cell

1992 • 4,138 citations

The mechanism of Z α1-antitrypsin accumulation in the liver

1992 • 1,030 citations

Protein translocation across the endoplasmic reticulum

1984 • 825 citations

Human α1-proteinase inhibitor

1984 • 773 citations

Protein degradation in the endoplasmic reticulum

1990 • 659 citations

Association of folding intermediates of glycoproteins with calnexin during protein maturation

1993 • 558 citations

SSR alpha and associated calnexin are major calcium binding proteins of the endoplasmic reticulum membrane.

1991 • 544 citations

The rate of bulk flow from the endoplasmic reticulum to the cell surface

1987 • 542 citations

Molecular basis of alpha-1-antitrypsin deficiency

1988 • 505 citations

Antielastases of the human alveolar structures. Implications for the protease-antiprotease theory of emphysema.

1981 • 441 citations

Complete sequence of the cDNA for human .alpha.1-antitrypsin and the gene for the S variant

1984 • 396 citations

The Induction of Pulmonary Emphysema with Human Leukocyte Elastase^1–3

1977 • 335 citations

Participation of a novel 88-kD protein in the biogenesis of murine class I histocompatibility molecules.

1991 • 312 citations

ERp99, an abundant, conserved glycoprotein of the endoplasmic reticulum, is homologous to the 90-kDa heat shock protein (hsp90) and the 94-kDa glucose regulated protein (GRP94).

1987 • 294 citations

Endoplasmic reticulum resident protein of 90 kilodaltons associates with the T- and B-cell antigen receptors and major histocompatibility complex antigens during their assembly.

1992 • 259 citations

A frameshift mutation results in a truncated alpha 1-antitrypsin that is retained within the rough endoplasmic reticulum.

1988 • 209 citations

Alpha 1-antitrypsin Siiyama (Ser53–>Phe). Further evidence for intracellular loop-sheet polymerization

1993 • 204 citations

Molecular basis of alpha-1-antitrypsin deficiency

1988 • 200 citations

Efficient dissociation of the p88 chaperone from major histocompatibility complex class I molecules requires both beta 2-microglobulin and peptide.

1992 • 184 citations

Protein sorting by selective retention in the endoplasmic reticulum and Golgi stack

1987 • 179 citations

Multiple tissues express alpha 1-antitrypsin in transgenic mice and man.

1988 • 153 citations

Soluble aggregates of the human PiZ alpha 1-antitrypsin variant are degraded within the endoplasmic reticulum by a mechanism sensitive to inhibitors of protein synthesis.

1992 • 123 citations

Accumulation of the insoluble PiZ variant of human alpha 1-antitrypsin within the hepatic endoplasmic reticulum does not elevate the steady-state level of grp78/BiP

1990 • 121 citations

Tissue specific expression of the human alpha-1-antitrypsin gene in transgenic mice

1987 • 117 citations

Intracellular degradation of the transport-impaired human PiZ alpha 1-antitrypsin variant. Biochemical mapping of the degradative event among compartments of the secretory pathway.

1990 • 111 citations

The p88 molecular chaperone is identical to the endoplasmic reticulum membrane protein, calnexin.

1992 • 110 citations

A vesicular intermediate in the transport of hepatoma secretory proteins from the rough endoplasmic reticulum to the Golgi complex.

1987 • 108 citations

Casein kinase II phosphorylation of signal sequence receptor alpha and the associated membrane chaperone calnexin.

1992 • 57 citations

Proteinase Inhibitors

1991 • 55 citations

Purification of a 90-kDa protein (Band VII) from cardiac sarcoplasmic reticulum. Identification as calnexin and localization of casein kinase II phosphorylation sites.

1993 • 50 citations

Secretion of alpha-1-proteinase inhibitor requires an almost full length molecule.

1992 • 50 citations

Alpha-1-antitrypsin Deficiency: Accumulation or Degradation of Mutant Variants within the Hepatic Endoplasmic Reticulum

1989 • 37 citations

Genetic variants of alpha‐1‐antitrypsin (AAT)

1992 • 31 citations