Back to search

Genetic basis of anxiety-like behaviour: a critical review

Data up to Jan 2025

Published2002
Citations166
References270

Total Citations Per Year

Abstract

References (270)

Manual for the State-Trait Anxiety Inventory

1970 • 25,384 citations

A Handbook of Child Psychology

1932 • 10,905 citations

Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

1985 • 5,596 citations

Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region

1996 • 5,154 citations

Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale

1997 • 4,531 citations

Genetic Dissection of Complex Traits

1994 • 3,497 citations

Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress

1997 • 3,131 citations

Central Dogma of Molecular Biology

1970 • 3,113 citations

The use of a plus-maze to measure anxiety in the mouse

1987 • 2,571 citations

A polymorphic DNA marker genetically linked to Huntington's disease

1983 • 2,329 citations

Molecular Biology of the Gene

1970 • 2,116 citations

Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety

1999 • 1,756 citations

Genetics of Mouse Behavior: Interactions with Laboratory Environment

1999 • 1,626 citations

Tests for emotionality in rats and mice: A review

1973 • 1,561 citations

Genetic variants and strains of the laboratory mouse

1990 • 1,519 citations

The validity of animal models of depression

1984 • 1,365 citations

Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies

1997 • 1,362 citations

Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines

1980 • 1,340 citations

Emotional behavior in the rat. I. Defecation and urination as measures of individual differences in emotionality.

1934 • 1,281 citations

Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA

1995 • 1,211 citations

On protein synthesis.

1958 • 1,174 citations

Benzodiazepine actions mediated by specific γ-aminobutyric acidA receptor subtypes

1999 • 1,154 citations

Molecular and Neuronal Substrate for the Selective Attenuation of Anxiety

2000 • 927 citations

Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor

1997 • 906 citations

Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype?

1996 • 895 citations

Measuring normal and pathological anxiety-like behaviour in mice: a review

2001 • 884 citations

Corticotropin Releasing Factor Receptor 1–Deficient Mice Display Decreased Anxiety, Impaired Stress Response, and Aberrant Neuroendocrine Development

1998 • 883 citations

Catechol- O -methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior

1998 • 859 citations

Ethologically-based animal models of anxiety disorders

1990 • 841 citations

Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress

2000 • 836 citations

A simple and reliable conflict procedure for testing anti-anxiety agents

1971 • 832 citations

The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs

1980 • 813 citations

Serotonin receptor 1A knockout: An animal model of anxiety-related disorder

1998 • 802 citations

The effects of meprobamate, barbiturates, d-amphetamine and promazine on experimentally induced conflict in the rat

1960 • 785 citations

Prenatal Stress Induces High Anxiety and Postnatal Handling Induces Low Anxiety in Adult Offspring: Correlation with Stress-Induced Corticosterone Secretion

1997 • 768 citations

Elevated anxiety and antidepressant-like responses in serotonin 5-HT 1A receptor mutant mice

1998 • 690 citations

Increased anxiety of mice lacking the serotonin 1A receptor

1998 • 684 citations

The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety

1999 • 656 citations

Do early‐life events permanently alter behavioral and hormonal responses to stressors?

1998 • 651 citations

RECOMBINANT-INBRED STRAINS AN AID TO FINDING IDENTITY, LINKAGE, AND FUNCTION OF HISTOCOMPATIBILITY AND OTHER GENES

1971 • 595 citations

The Effects of Early Rearing Environment on the Development of GABAA and Central Benzodiazepine Receptor Levels and Novelty-Induced Fearfulness in the Rat

2000 • 594 citations

Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2

2000 • 591 citations

Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues

1999 • 552 citations

Attenuated sensitivity to neuroactive steroids in γ-aminobutyrate type A receptor delta subunit knockout mice

1999 • 522 citations

Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines

1981 • 509 citations

Behavioral effects of estrogen receptor gene disruption in male mice

1997 • 502 citations

A multiple-test study of anxiety-related behaviours in six inbred rat strains

1997 • 497 citations

Detecting marker-QTL linkage and estimating QTL gene effect and map location using a saturated genetic map.

1993 • 493 citations

Deletion of Crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2

2000 • 490 citations

Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin

1996 • 485 citations

Normally occurring environmental and behavioral influences on gene activity: From central dogma to probabilistic epigenesis.

1998 • 475 citations

Insensitivity of the analysis of variance to heredity-environment interaction

1990 • 470 citations

Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior

1994 • 462 citations

Differences in fear motivated behaviors among inbred mouse strains

1993 • 450 citations

Locomotor Activity in D2 Dopamine Receptor-Deficient Mice Is Determined by Gene Dosage, Genetic Background, and Developmental Adaptations

1998 • 448 citations

A Simple Genetic Basis for a Complex Psychological Trait in Laboratory Mice

1995 • 447 citations

Dopamine D4 Receptor-Knock-Out Mice Exhibit Reduced Exploration of Novel Stimuli

1999 • 435 citations

A gene for the mouse pink-eyed dilution locus and for human type II oculocutaneous albinism

1993 • 411 citations

Differences in anxiety-related behaviours and in sensitivity to diazepam in inbred and outbred strains of mice

2000 • 407 citations

The Maudsley Reactive and Nonreactive strains of rats: A survey

1975 • 344 citations

Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

2000 • 336 citations

Psychiatric genetics: search for phenotypes

1998 • 334 citations

Behavioural profiles of two Wistar rat lines selectively bred for high or low anxiety-related behaviour

1998 • 323 citations

α7 Nicotinic Receptor Subunits Are Not Necessary for Hippocampal-Dependent Learning or Sensorimotor Gating: A Behavioral Characterization of Acra7-Deficient Mice

1998 • 295 citations

Cultural versus biological inheritance: phenotypic transmission from parents to children. (A theory of the effect of parental phenotypes on children's phenotypes).

1973 • 293 citations

Function and pharmacology of multiple GABAA receptor subunits

1991 • 292 citations

Behavioral characterization of neuropeptide Y knockout mice

2000 • 287 citations

Comparison of different behavioral test situations used in psychopharmacology for measurement of anxiety

1994 • 286 citations

The coming Kuhnian revolution in biology

1997 • 282 citations

Response to 30 generations of selection for open-field activity in laboratory mice

1978 • 264 citations

Population studies of polymorphisms of the serotonin transporter protein gene.

1999 • 251 citations

Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice

1999 • 247 citations

Life without neuropeptide Y.

1998 • 244 citations

Maternal imprinting of the mouse Snrpn gene and conserved linkage homology with the human Prader–Willi syndrome region

1992 • 243 citations

Stress-induced behaviors require the corticotropin-releasing hormone (CRH) receptor, but not CRH

1999 • 242 citations

Polygenic disease: methods for mapping complex disease traits

1995 • 239 citations

Phenotypic characterization of an alpha 4 neuronal nicotinic acetylcholine receptor subunit knock-out mouse.

2000 • 236 citations

The free-exploratory paradigm

1993 • 234 citations

The Mouse Pink-Eyed Dilution Gene: Association with Human Prader-Willi and Angelman Syndromes

1992 • 231 citations

High-resolution mapping of quantitative trait loci in outbred mice

1999 • 230 citations

5-HT1B Receptor Knock-Out Mice Exhibit Increased Exploratory Activity and Enhanced Spatial Memory Performance in the Morris Water Maze

1999 • 227 citations

Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 11Published on the World Wide Web on 27 November 1998.1

1999 • 224 citations

Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase

1999 • 216 citations

Handbook on genetically standardized jax mice

1991 • 212 citations

Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive compulsive disorder

1998 • 205 citations

Population studies of polymorphisms of the serotonin transporter protein gene

1999 • 203 citations

Phenotypic Characterization of an α4 Neuronal Nicotinic Acetylcholine Receptor Subunit Knock-Out Mouse

2000 • 202 citations

5-HT1 receptor knock out — behavioral consequences

1995 • 201 citations

Rearing environmental enrichment in two inbred strains of mice: 1. Effects on emotional reactivity.

1999 • 201 citations

Increased Exploratory Activity and Altered Response to LSD in Mice Lacking the 5-HT5A Receptor

1999 • 197 citations

Psychiatric Disorders Associated With Fragile X in the Young Female

1993 • 195 citations

Panic and Phobic Anxiety: Defining Phenotypes for Genetic Studies

1998 • 194 citations

Sustained Long Term Potentiation and Anxiety in Mice Lacking theMas Protooncogene

1998 • 192 citations

Mapping quantitative trait loci for open-field behavior in mice.

1997 • 187 citations

Genes for Epilepsy Mapped in the Mouse

1991 • 187 citations

Environmental enrichment in BALB/c mice

2001 • 184 citations

Unusual behavioral phenotypes of inbred mouse strains

1996 • 184 citations

Selection, evolution of behavior and animal models in behavioral neuroscience

1999 • 184 citations

The effects of early postnatal stimulation on Morris water-maze acquisition in adult mice: genetic and maternal factors

1996 • 183 citations

Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains

1994 • 181 citations

Localization of the gene encoding the GABAA receptor beta 3 subunit to the Angelman/Prader-Willi region of human chromosome 15.

1991 • 177 citations

Use of recombinant inbred strains to detect quantitative trait loci associated with behavior

1991 • 172 citations

Pharmacological blockade or genetic deletion of substance P (NK1) receptors attenuates neonatal vocalisation in guinea-pigs and mice

2000 • 171 citations

Use of recombinant inbred strains to identify quantitative trait loci in psychopharmacology

1991 • 171 citations

Strain Differences in Open-Field and Elevated Plus-Maze Behavior of Rats Without and With Pretest Handling

1998 • 169 citations

Anxiogenic effects of methyl-β-carboline-3-carboxylate in a light/dark choice situation

1987 • 169 citations

Quantitative trait locus analysis of contextual fear conditioning in mice

1997 • 169 citations

Anxiety, motor activation, and maternal-infant interactions in 5HT-sub(1B ) knockout mice.

1999 • 166 citations

Anxiety, motor activation, and maternal–infant interactions in 5HT1B knockout mice.

1999 • 164 citations

5-HT2C (HTR2C)serotonin receptor gene polymorphism associated with the human personality trait of reward dependence: Interaction with dopamine D4 receptor (D4DR) and dopamine D3 receptor (D3DR) polymorphisms

1997 • 162 citations

Systematic mutation screening and association study of the A1 and A2a adenosine receptor genes in panic disorder suggest a contribution of the A2a gene to the development of disease

1998 • 160 citations

Biological bases of anxiety

1998 • 157 citations

Effects of early experience on c-fos gene expression in the chick forebrain

1991 • 157 citations

Altered anxiety and weight gain in corticotropin-releasing hormone-binding protein-deficient mice

1999 • 151 citations

Quantitative trait loci analysis affecting contextual conditioning in mice

1997 • 150 citations

Expression of Drosophila mushroom body mutations in alternative genetic backgrounds: a case study of the mushroom body miniature gene (mbm).

1996 • 149 citations

The inactivation of adrenaline

1937 • 149 citations

Link between emotional memory and anxiety states: A study by principal component analysis

1995 • 149 citations

Reduced spontaneous activity of mice defective in the ε4 subunit of the NMDA receptor channel

1995 • 145 citations

Behavioral and neurochemical changes following predatory stress in mice

2001 • 145 citations

Muscular dystrophy in an X; 1 translocation female suggests that Duchenne locus is on X chromosome short arm.

1979 • 143 citations

D3 Dopamine Receptor-Deficient Mouse: Evidence for Reduced Anxiety

1997 • 142 citations

Disruption of the midkine gene (Mdk) resulted in altered expression of a calcium binding protein in the hippocampus of infant mice and their abnormal behaviour

1998 • 140 citations

Reduced Aggressive Behaviour in Mice with Targeted Disruption of the Oxytocin Gene

1997 • 138 citations

Stocks for detecting linkage in the mouse, and the theory of their design

1951 • 138 citations

Some Conceptual Deficiencies in ‘Developmental’ Behavior Genetics

1995 • 137 citations

The inheritance of behavior: behavioural differences in fifteen mouse strains.

1953 • 137 citations

Pharmacologic and Behavioral Responses of Inbred C57BL/6J and Strain 129/SvJ Mouse Lines

1999 • 136 citations

Animal Models in Psychiatry

1974 • 135 citations

Early and Later Adoptions Have Different Long-Term Effects on Male Rat Offspring

1996 • 134 citations

Comparative map for mice and humans

1992 • 133 citations

Open field and elevated plus-maze: A behavioural comparison between spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats and the effects of chlordiazepoxide

1987 • 133 citations

On Some Fundamental Concepts of Darwinian Biology

1968 • 132 citations

Anxiety and increased 5-HT1A receptor response in NCAM null mutant mice

1999 • 131 citations

Role of experimental conditions in determining differences in exploratory behavior of prenatally stressed rats

1996 • 127 citations

Recovery of emotional behaviour in neural cell adhesion molecule (NCAM) null mutant mice through transgenic expression of NCAM180

2000 • 127 citations

Age at onset of panic disorder: influence of familial liability to the disease and of childhood separation anxiety disorder

1995 • 123 citations

GABA and behavior: The role of receptor subtypes

1992 • 122 citations

Does neophobia necessarily imply fear or anxiety?

1986 • 122 citations

Localisation of the Becker muscular dystrophy gene on the short arm of the X chromosome by linkage to cloned DNA sequences

1984 • 121 citations

Anxiety-like behavior in mice lacking the angiotensin II type-2 receptor

1999 • 118 citations

Handbook of Molecular-Genetic Techniques for Brain and Behavior Research

1999 • 118 citations

5-HT1 receptors and behavior

1992 • 114 citations

Further pharmacological validation of the BALB/c neophobia in the free exploratory paradigm as an animal model of trait anxiety

1997 • 109 citations

Possible association of a cholecystokinin promotor polymorphism (CCK-36CT) with panic disorder

1998 • 107 citations

Anti-sexual and anxiogenic behavioral consequences of corticotropin-releasing factor overexpression are centrally mediated

1997 • 105 citations

Normal inhibitory avoidance learning and anxiety, but increased locomotor activity in mice devoid of PrPC

1999 • 104 citations

Gene‐teratogen interaction in insulin‐induced mouse exencephaly

1980 • 103 citations

Behavioral responses to stress are intact in CRF-deficient mice

1999 • 102 citations

Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (Sim2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome

2000 • 102 citations

Modulation of mice anxiety in response to cat odor as a consequence of predators diet

1998 • 99 citations

Superior Water Maze Performance and Increase in Fear-Related Behavior in the Endothelial Nitric Oxide Synthase-Deficient Mouse Together with Monoamine Changes in Cerebellum and Ventral Striatum

2000 • 97 citations

Quantitative trait loci (QTL) applications to substances of abuse: Physical dependence studies with nitrous oxide and ethanol in BXD mice

1993 • 97 citations

Intact spatial learning and memory in transgenic mice with reduced BDNF

1997 • 96 citations

Family genetic studies of panic disorder

1993 • 96 citations

Epilepsy in Angelman Syndrome Associated with Chromosome 15q Deletion

1992 • 96 citations

Behavioural Validation of a Light/Dark Choice Procedure for Testing Anti-Anxiety Agents

1989 • 95 citations

Excess corticotropin releasing hormone-binding protein in the hypothalamic-pituitary-adrenal axis in transgenic mice.

1998 • 94 citations

Genetic analysis of anxiety-related behaviors and responses to benzodiazepine-related drugs in AXB and BXA recombinant inbred mouse strains

1995 • 91 citations

COMT andDRD3 polymorphisms, environmental exposures, and personality traits related to common mental disorders

2000 • 91 citations

Genetic selection for ethanol withdrawal severity: Differences in replicate mouse lines

1983 • 89 citations

The recombinant congenic strains for analysis of multigenic traits: genetic composition

1992 • 88 citations

Genetics of Psychiatric Disease

2000 • 86 citations

A major quantitative trait locus influences hyperactivity in the WKHA rat

1996 • 86 citations

Gene–environment interaction for body size and larval density in Drosophila melanogaster: an investigation of effects on development time, thorax length and adult sex ratio

1994 • 85 citations

Mapping quantitative trait loci for behavioral traits in the mouse

1992 • 85 citations

Quantitative trait loci (QTL) analyses and alcohol-related behaviors

1993 • 81 citations

Increased fearfulness of Fyn tyrosine kinase deficient mice

1994 • 81 citations

SINGLE-GENE INFLUENCES ON BRAIN AND BEHAVIOR

1999 • 78 citations

THE INHERITANCE OF BEHAVIOR

1956 • 76 citations

Increased Anxiety and Impaired Pain Response in Puromycin-Sensitive Aminopeptidase Gene-Deficient Mice Obtained by a Mouse Gene-Trap Method

1999 • 75 citations

IL-6 deficiency leads to increased emotionality in mice: evidence in transgenic mice carrying a null mutation for IL-6

1998 • 74 citations

The genetic basis of cognition

1999 • 74 citations

Radial maze performance, open-field and elevated plus-maze behaviors in Fyn-kinase deficient mice: Further evidence for increased fearfulness

1996 • 74 citations

A twin-family study of self-report symptoms of panic-phobia and somatization

1995 • 74 citations

A variable-number-tandem-repeat of the serotonin transporter gene and anxiety disorders

1999 • 72 citations

Striking changes in anxiety in Huntington's disease transgenic mice

1998 • 71 citations

CRH Overproduction in Transgenic Mice

1996 • 69 citations

Selectively Bred Lines of Rats Differ in Social Interaction and Hippocampal 5-HT1A Receptor Function: A Link Between Anxiety and Depression?

1998 • 67 citations

Five generations of selective breeding for ultrasonic vocalization (USV) responses in N:NIH strain rats

1997 • 66 citations

Behavioral and neuroendocrine reactivity to stress in the WKHA/WKY inbred rat strains: a multifactorial and genetic analysis

1996 • 65 citations

Elevated plus-maze behavior in adult offspring of selectively bred rats

1996 • 65 citations

Tactile sensory input regulates basal and apomorphine‐induced immediate‐early gene expression in rat barrel cortex

1994 • 61 citations

Flumazenil induces benzodiazepine partial agonist-like effects in BALB/c but not C57BL/6 mice

2000 • 61 citations

Genetic differences in the mouse defense test battery

1997 • 60 citations

Behavioral reactivity to aversive stimuli in a transgenic mouse model of impaired glucocorticoid (type II) receptor function: effects of diazepam and FG-7142

1997 • 60 citations

Factor-derived subsyndromes of schizophrenia and familial morbid risks

1997 • 58 citations

Fear decrease in transgenic mice over-expressing bcl-2 in neurons

1997 • 55 citations

Exploratory and Displacement Behavior in Transgenic Mice Expressing High Levels of Brain TNF-α

1998 • 54 citations

Comparative study of emotional behaviour in three inbred strains of mice

1999 • 54 citations

Mouse Chromosome 7

1992 • 53 citations

Mice lacking the cell adhesion molecule Thy-1 fail to use socially transmitted cues to direct their choice of food

2000 • 53 citations

Expression of immediate early genes in the hippocampal formation of the black-capped chickadee (Poecile atricapillus) during a food-hoarding task

2000 • 52 citations

Central serotonergic systems in the spontaneously hypertensive and Lewis rat strains that differ in the elevated plus-maze test of anxiety.

1997 • 51 citations

Anxiety in a transgenic mouse model of cortical-limbic neuropotentiated compulsive behavior

1999 • 50 citations

The Influence of a Targeted Deletion of the IFNγ Gene on Emotional Behaviors

1998 • 50 citations

Genetic factors and the measurement of exploratory activity

1987 • 48 citations

Anxiety-like behavior in transgenic mice with brain expression of neuropeptide Y.

1998 • 47 citations

Reduction of depressive-like behavior in mice lacking angiotensinogen

1999 • 47 citations

Comparison of anxiety measured in the elevated plus-maze, open-field and social interaction tests between spontaneously hypertensive rats and Wistar EPM-1 rats.

1993 • 47 citations

Amygdala kindling-resistant (SLOW) or -prone (FAST) rat strains show differential fear responses.

1998 • 46 citations

Sex chromosomes and speciation

1991 • 45 citations

Amygdala kindling-resistant (SLOW) or -prone (FAST) rat strains show differential fear responses.

1998 • 44 citations

PD135158, a CCK-B antagonist, reduces “state,” but not “trait” anxiety in mice

1994 • 41 citations

Origins of individual differences in anxiety proneness: a twin/adoption study of the anxiety‐related scales from the Karolinska Scales of Personality (KSP)

1996 • 41 citations

Behavioral and neurochemical differences between Fischer 344 and Harlan-Wistar rats raised identically.

1999 • 41 citations

Towards a genetics of anxious temperament: from mice to men

1998 • 40 citations

Candidate gene study of eight GABAA receptor subunits in panic disorder

1997 • 40 citations

Behavioural changes produced by transgenic overexpression of γ2L and γ2S subunits of the GABAA receptor

2000 • 40 citations

Update on chromosomal locations for psychiatric disorders: Report of the interim meeting of chromosome workshop chairpersons from the VIIth World Congress of Psychiatric Genetics, Monterey, California, October 14-18, 1999

2000 • 40 citations

Familial vulnerability factors to post‐traumatic stress disorder in male military veterans

1996 • 40 citations

Genetic and environmental influences on behavioral and neurochemical aspects of emotionality in rats

1988 • 39 citations

Alterations in behavior, steroid hormones and natural killer cell activity in male transgenic TGFα mice

1992 • 38 citations

Heredity of Wildness and Savageness in Mice.

1923 • 38 citations

Analysis of the pseudoautosomal X-linked geneSYBL1in bipolar affective disorder: Description of a new candidate allele for psychiatric disorders

2000 • 37 citations

Involvement of regions of the 4th and 7th chromosomes in the open-field activity of mice

1995 • 37 citations

Genetic factors regulate processes related to anxiety in mice

1997 • 37 citations

Roman strains as a psychogenetic model for the study of working memory: Behavioral and biochemical data

1991 • 37 citations

Learning and anxiety in angiotensin-deficient mice

1999 • 36 citations

Emotionality and audiogenic seizure susceptibility in five inbred strains of mice.

1951 • 35 citations

Rearing responses and locomotor activity in mice: Single-locus control

1977 • 35 citations

Quantitative Trait Locus Analyses of Sleep‐Times Induced by Sedative‐Hypnotics in LSXSS Recombinant Inbred Strains of Mice

1996 • 35 citations

Adrenergic receptor genes as candidate genes for panic disorder: a linkage study

1992 • 35 citations

Arm width and brightness modulation of spontaneous behaviour of two strains of mice tested in the elevated plus-maze

1996 • 34 citations

Gene-environment interaction: a significant diet-dependent obesity locus demonstrated in a congenic segment on mouse Chromosome 7 Mus castaneus. -->

1999 • 34 citations

Lines of mice selected for reproductive longevity.

1995 • 33 citations

Animal Models in Psychiatry, 11

1992 • 32 citations

Larval Behavior of Drosophila Central Complex Mutants: Interactions Between No Bridge, Foraging, and Chaser

1996 • 32 citations

The many faces of social anxiety disorder

2000 • 29 citations

Divergent levels of anxiety in mice selected for differences in sensitivity to a convulsant agent

2000 • 29 citations

INHERITANCE OF WILDNESS AND TAMENESS IN MICE

1932 • 27 citations

Age- and stimulus-dependent changes in anxiety-related behaviour of transgenic mice with GR dysfunction

1998 • 27 citations

Mouse Chromosomes 4 and 13 Are Involved in β-Carboline-Induced Seizures

1995 • 27 citations

Expression of c-Fos in the main olfactory bulb of neonatal rabbits in response to garlic as a novel and conditioned odour

1999 • 26 citations

Linkage Analysis between Manic-Depressive Illness and the Region on Chromosome 15q Involved in Prader-Syndrome, including Two GABA<sub>A</sub> Receptor Subtype Genes

1994 • 26 citations

The effects of umespirone as a potential anxiolytic and antipsychotic agent

1991 • 26 citations

Evolution Proposes and Ontogeny Disposes

2000 • 25 citations

The role of cognitive and affective processing in a transgenic mouse model of cortical-limbic neuropotentiated compulsive behavior.

1999 • 24 citations

Genetic selection of mouse lines differing in sensitivity to a benzodiazepine receptor inverse agonist

1998 • 24 citations

Multiple Seizure Susceptibility Genes on Chromosome 7 in SWXL-4 Congenic Mouse Strains

2000 • 23 citations

Mapping quantitative trait loci that regulate sensitivity and tolerance to quinpirole, a dopamine mimetic selective for D2/D3 receptors

2000 • 22 citations

Quick Method for Confirmation of Quantitative Trait Loci

1997 • 21 citations

The role of cognitive and affective processing in a transgenic mouse model of cortical-limbic neuropotentiated compulsive behavior.

1999 • 20 citations

Animal Models of Anxiety and the Screening and Development of Novel Anxiolytic Drugs

2003 • 20 citations

The effects of intrauterine position on the degree of corpus callosum deficiency in two substrains of BALB/c mice

1991 • 18 citations

Serotonin in anxiety: evidence from animal models

1991 • 18 citations

Blockade of anxiolytic-like actions of chlordiazepoxide by naloxone in the elevated plus-maze: Comparisons between Swiss, C57BL/6, and BALB/c mice

1999 • 18 citations

The panic-agoraphobic syndrome: a paradigm of the anxiety group of disorders and its implications for psychiatric practice and theory

1996 • 18 citations

Association of autosomal loci with the grooming activity in mice observed in open-field

1994 • 17 citations

Excluding linkage between panic disorder and the gamma‐aminobutyric acid beta 1 receptor locus in five Icelandic pedigrees

1993 • 17 citations

Differential open field reactivity in HAS and LAS rats

1995 • 16 citations

The Genetics of Panic Disorder and Generalized Anxiety Disorder

1993 • 16 citations

D1 and D2 dopamine receptor turnover and D2 messenger RNA levels in the neuroleptic-responsive and the neuroleptic nonresponsive lines of mice.

1993 • 15 citations

5-Hydroxytryptamine in Psychiatry

1992 • 13 citations

Study of the modulatory activity of bz (ω) receptor ligands on defensive behaviors in mice: Evaluation of the importance of intrinsic efficacy and receptor subtype selectivity

1999 • 12 citations

Serotonin and genetic differences in sensitivity and tolerance to ethanol hypothermia

1993 • 11 citations

Evaluation of neurological mouse mutants caused by ENU mutagenesis

2000 • 9 citations

A mouse mutant strain highly resistant to methyl ?-carboline-3-carboxylate-induced seizures

1996 • 8 citations

Éléments d'éthologie cognitive

2000 • 8 citations

Estimating heritabilities in quantitative behavior genetics: A station passed

1990 • 8 citations

The serotonin 5-HT1B receptor subtype (Htr1b) gene maps to mouse Chromosome 9

1993 • 7 citations

Genetically defined animal models of neurobehavioral dysfunctions

1993 • 6 citations

Immunocytochemical analysis of glutamate and GABA in selectively bred mice

1997 • 5 citations

[Molecular genetics: a new approach of clinical neurosciences].

1991 • 4 citations

Genetic dissection of a complex trait

1999 • 4 citations

5-HT RECEPTOR TYPES AND ANXIETY

1992 • 4 citations

A strategy to home‐in on polygenes influencing susceptibility to anxiety

1999 • 3 citations

A strategy to home‐in on polygenes influencing susceptibility to anxiety

1999 • 3 citations

The anatomy of a clinical trial

1999 • 2 citations

Deleted Work

1955 • 0 citations

Cited By (0)

Loading...