The effects of umespirone as a potential anxiolytic and antipsychotic agent

The rat forebrain in stereotaxic coordinates

1959 • 1,391 citations

The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs

1980 • 813 citations

Clinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia

1989 • 600 citations

Exploration of mice in a black and white test box: Validation as a model of anxiety

1989 • 535 citations

Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines

1981 • 509 citations

The comparative efficacy of buspirone and diazepam in the treatment of anxiety

1979 • 426 citations

Characterization of the 5-hydroxytryptamine1a receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig and rat hippocampal membranes.

1986 • 420 citations

5-HT1A receptor-related anxiolytics

1987 • 402 citations

Selective interaction of novel anxiolytics with 5-hydroxytryptamine1A receptors

1985 • 367 citations

Effects of the 5‐HT₃ receptor antagonist, GR38032F, on raised dopaminergic activity in the mesolimbic system of the rat and marmoset brain

1987 • 354 citations

The potential anxiolytic activity of GR38032F, a 5‐HT₃‐receptor antagonist

1988 • 332 citations

Animal models of anxiety: the effect of compounds that modify 5-HT neurotransmission

1987 • 280 citations

Inhibition of serotonergic dorsal raphe neurons by systemic and iontophoretic administration of buspirone, a non-benzodiazepine anxiolytic drug

1986 • 231 citations

Serotonergic mechanisms in the behavioral effects of buspirone and gepirone

1986 • 194 citations

5-HT: The Enigma Variations

1987 • 167 citations

Novel anxiolytics discriminate between postsynaptic serotonin receptors mediating different physiological responses on single neurons of the rat hippocampus

1987 • 144 citations

Piperazine derivatives including the putative anxiolytic drugs, buspirone and ipsapirone, are agonists at 5-HT1A receptors negatively coupled with adenylate cyclase in hippocampal neurons

1987 • 136 citations

Are there selective ligands for 5-HT1A and 5-HT1B receptor binding sites in brain?

1986 • 136 citations

Recent developments in 5HT-related pharmacology of animal models of anxiety

1986 • 127 citations

The mechanism(s) of action of the benzodiazepines

1981 • 117 citations

Characterization of MDL 73005EF as a 5‐HT_1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8‐OH‐DPAT and diazepam

1990 • 113 citations

Buspirone, a new approach to the treatment of anxiety

1988 • 104 citations

Clozapine and the Dopamine Hypothesis of Schizophrenia, a Critical Appraisal

1975 • 99 citations

Benzodiazepine interactions with GABA receptors

1984 • 85 citations

Autoradiographic identification and topographical analyses of high affinity serotonin receptor subtypes as a target for the novel putative anxiolytic TVX Q 7821

1985 • 77 citations

Actions of Buspirone in a Putative Model of Anxiety in the Mouse

1988 • 68 citations

Isapirone is a partial agonist at 5-hydroxytryptamine1A (5-HT1A) receptors in the rat hippocampus: electrophysiological evidence

1987 • 63 citations

The psychopharmacology and treatment of schizophrenia

1987 • 60 citations

Basic biology of clozapine: electrophysiological and neuroendocrinological studies

1989 • 39 citations

Withdrawal syndrome following subchronic treatment with anxiolytic agents

1987 • 39 citations

Buspirone decreases the activity of 5-hydroxytryptamine-containing dorsal raphe neurons in-vitro

1986 • 38 citations

Is it possible to model psychotic states in animals?

1987 • 22 citations

Binding of umespirone to the σ receptor: Evidence for multiple affinity states

1990 • 22 citations

Long-term consequences of antagonism by neuroleptics of behavioural events occurring during mesolimbic dopamine infusion

1984 • 19 citations

KC 9172* (Free Base of KC 7218) - An Antipsychotic/Anxiolytic Compound I. Antipsychotic and Anxiolytic Activity in Comparison with Chlorpromazine, Clozapine, Diazepam and Buspirone

1988 • 9 citations

KC 9172* (Free Base of KC 7218) - An Antipsychotic/Anxiolytic Compound II. Discrimiantion from Typical Neuroleptics and Benzodiazepine-like Minor Tranquilizers

1988 • 9 citations

Biochemical and Molecular Mechanisms of Action of Neuroleptics, Alternatives to the Classical Dopamine Hypothesis: Minutes of the Discussion Group

1986 • 4 citations