IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Atlas of protein sequence and structure

1965 • 4,462 citations

A better cell line for making hybridomas secreting specific antibodies

1978 • 1,649 citations

Atlas of Protein Sequence and Structure, 1966.

1967 • 1,463 citations

AN ANALYSIS OF THE SEQUENCES OF THE VARIABLE REGIONS OF BENCE JONES PROTEINS AND MYELOMA LIGHT CHAINS AND THEIR IMPLICATIONS FOR ANTIBODY COMPLEMENTARITY

1970 • 1,308 citations

Biology of the Mouse Histocompatibility-2 Complex

1975 • 1,145 citations

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH

1980 • 872 citations

Sequences at the somatic recombination sites of immunoglobulin light-chain genes

1979 • 859 citations

Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes

1980 • 803 citations

A complete immunoglobulin gene is created by somatic recombination.

1978 • 610 citations

Sequences of mouse immunoglobulin light chain genes before and after somatic changes

1978 • 495 citations

Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene.

1979 • 472 citations

Early production of intracellular IgM by B-lymphocyte precursors in mouse

1976 • 435 citations

Direct microsequence analysis of polypeptides using an improved sequenator, a nonprotein carrier (Polybrene), and high pressure liquid chromatography

1978 • 382 citations

Affinity labeling of a phosphorylcholine binding mouse myeloma protein

1972 • 349 citations

Analysis of the repertoire of anti‐NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response

1978 • 316 citations

Origin of Antibody Variation

1966 • 314 citations

An immunoglobulin heavy-chain gene is formed by at least two recombinational events

1980 • 306 citations

Immunologic Specificity and Molecular Structure

1963 • 301 citations

Amino acid sequence of homogeneous antibodies to dextran and DNA rearrangments in heavy chain V-region gene segments

1980 • 272 citations

Antigen-Binding Myeloma Proteins of Mice

1978 • 272 citations

Light Chain Evolution

1967 • 263 citations

THE GENETIC CONTROL OF IMMUNOGLOBULIN SYNTHESIS

1972 • 249 citations

GENETICS OF A NEW IgVH (T15 IDIOTYPE) MARKER IN THE MOUSE REGULATING NATURAL ANTIBODY TO PHOSPHORYLCHOLINE

1974 • 247 citations

Antibody Diversity

1978 • 240 citations

The Three Dimensional Structure of a Combining Region-Ligand Complex of Immunoglobulin NEW at 3.5-Å Resolution

1974 • 227 citations

Linked Groups of Residues in Immunoglobulin κ Chains

1967 • 216 citations

Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch.

1980 • 213 citations

Rearrangement of genetic information may produce immunoglobulin diversity

1978 • 209 citations

Is terminal deoxynucleotidyl transferase a somatic mutagen in lymphocytes?

1974 • 205 citations

Specific Inhibition of Plaque Formation to Phosphorylcholine by Antibody against Antibody

1972 • 200 citations

Inheritance of an idiotype associated with the immune response of inbred mice to phosphorylcholine

1972 • 157 citations

Analysis of phenylthiohydantoin amino acids by high-performance liquid chromatography on DuPont Zorbax cyanopropylsilane columns

1979 • 145 citations

Somatic Changes in the Content and Context of Immunoglobulin Genes

1977 • 132 citations

Immunoglobulin heavy chain gene organization in mice: analysis of a myeloma genomic clone containing variable and alpha constant regions.

1979 • 131 citations

Comprehensive immunology

1982 • 129 citations

Hybridoma proteins expressing the predominant idiotype of the antiazophenylarsonate response of A/J mice.

1980 • 129 citations

Heterogeneity of the BALB/c antiphosphorylcholine antibody response at the precursor cell level.

1975 • 121 citations

Structure at 4.5 Å; Resolution of a Phosphorylcholine-binding Fab

1973 • 113 citations

Genetic Control of Antibody Variable Regions

1977 • 112 citations

Differentiated B lymphocytes. Potential to express particular antibody variable and constant regions depends on site of lymphoid tissue and antigen load.

1979 • 107 citations

Mice whose B cells cannot produce the T15 idiotype also lack an antigen-specific helper T cell required for T15 expression.

1979 • 102 citations

Neonatal Tolerance Induced by Antibody against Antigen-Specific Receptor

1974 • 97 citations

Variable Region Sequences of Five Human Immunoglobulin Heavy Chains of the V _H III Subgroup: Definitive Identification of Four Heavy Chain Hypervariable Regions

1974 • 92 citations

Immunoglobulin Structure: Amino Terminal Sequences of Mouse Myeloma Proteins That Bind Phosphorylcholine

1974 • 89 citations

Late acquisition of a germ line antibody specificity

1976 • 81 citations

Structural studies on induced antibodies with defined idiotypic specificities. IX. Framework differences in the heavy- and light-chain-variable regions of monoclonal anti-p-azophenylarsonate antibodies from A/J mice differing with respect to a cross-reactive idiotype.

1980 • 73 citations

Uniformity in the clonal repertoire for the immune response to phosphorylcholine in mice

1976 • 69 citations

Inbred strains in biomedical research

1980 • 65 citations

CH gene rearrangements in IgM-bearing B cells and in the normal splenic DNA component of hybridomas making different isotypes of antibody

1980 • 61 citations

Size differences among immunoglobulin heavy chains from phosphorylcholine-binding proteins.

1976 • 61 citations

Variable region sequence of the heavy chain from a phosphorylcholine binding myeloma protein

1974 • 60 citations

The Structure and Genetics of Mouse Immunoglobulins: An Analysis of NZB Myeloma Proteins and Sets of BALB/c Myeloma Proteins Binding Particular Haptens

1977 • 58 citations

Organization of kappa light chain genes in germ-line and somatic tissue.

1980 • 54 citations

Immunoglobulins with hapten‐binding activity: structure‐function correlations and genetic implications

1978 • 51 citations

FIRST ORDER CONSIDERATIONS IN ANALYZING THE GENERATOR OF DIVERSITY

1974 • 45 citations

Restriction in IgM expression—1

1980 • 37 citations

Specificity of Antibodies: Primary Structural Basis of Hapten Binding

1974 • 36 citations

Expression of equivalent clonotypes in BALB/c and A/J mice after immunization with phosphorylcholine.

1976 • 28 citations

κ Chain variable region from M167, a phosphorylcholine binding myeloma protein

1978 • 22 citations

Phosphorylcholine‐binding hybridoma proteins of normal and idiotypically suppressed BALB/c mice. II. Variable region N‐terminal amino acid sequences

1980 • 22 citations

Immune response to phosphorylcholine. I. Characterization of the epitope‐specific antibody

1975 • 16 citations

Idiotype sharing by murine strains differing in immunoglobulin allotype

1978 • 12 citations

THE ORGANIZATION AND REARRANGEMENT OF HEAVY CHAIN IMMUNOGLOBULIN GENES IN MICE

1979 • 10 citations