High-frequency expression of a conserved kappa light-chain variable-region gene in chronic lymphocytic leukemia.

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination

1977 • 3,548 citations

Ribonucleic acid isolated by cesium chloride centrifugation

1974 • 2,263 citations

Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a variable region

1981 • 677 citations

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin.

1984 • 545 citations

Human T cell antigens defined by monoclonal antibodies: the 65,000-dalton antigen of T cells (T65) is also found on chronic lymphocytic leukemia cells bearing surface immunoglobulin.

1980 • 429 citations

CROSS-IDIOTYPIC SPECIFICITY AMONG MONOCLONAL I<scp>G</scp>M PROTEINS WITH ANTI-γ-GLOBULIN ACTIVITY

1973 • 429 citations

Human Immunoglobulin Heavy Chain Genes Map to a Region of Translocations in Malignant B Lymphocytes

1982 • 351 citations

Enzyme Coupled Immunoassay of Insulin Using a Novel Coupling Reagent

1976 • 332 citations

Identification of a p69,71 complex expressed on human T cells sharing determinants with B-type chronic lymphatic leukemic cells.

1980 • 306 citations

Chromosomal location of human kappa and lambda immunoglobulin light chain constant region genes

1982 • 292 citations

Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma

1986 • 279 citations

A new reagent which may be used to introduce sulfhydryl groups into proteins, and its use in the preparation of conjugates for immunoassay

1983 • 261 citations

Localization of human immunoglobulin kappa light chain variable region genes to the short arm of chromosome 2 by in situ hybridization.

1982 • 242 citations

Clusters of point mutations are found exclusively around rearranged antibody variable genes.

1983 • 233 citations

Linked Groups of Residues in Immunoglobulin κ Chains

1967 • 216 citations

The Genetics of Antibody Diversity

1982 • 214 citations

SIMILARITIES IN THE LIGHT CHAINS OF ANTI-γ-GLOBULINS SHOWING CROSS-IDIOTYPIC SPECIFICITIES

1974 • 171 citations

A conserved human germline V kappa gene directly encodes rheumatoid factor light chains.

1986 • 166 citations

Differences between germ-line and rearranged immunoglobulin Vκ coding sequences suggest a localized mutation mechanism

1981 • 161 citations

The Generation of Diversity in Phosphorylcholine-Binding Antibodies

1984 • 153 citations

The genetic basis of antibody production: A single heavy chain variable region gene encodes all molecules bearing the dominant anti-arsonate idiotype in the strain A mouse

1983 • 151 citations

Anti-Human Immunoglobulin G Activity of Membrane-Bound Monoclonal Immunoglobulin M in Lymphoproliferative Disorders

1972 • 121 citations

Structure of Antibodies with Shared Idiotypy: The Complete Sequence of the Heavy Chain Variable Regions of Two Immunoglobulin M Anti-Gamma Globulins

1974 • 115 citations

A common idiotope on human rheumatoid factors identified by a hybridoma antibody

1983 • 114 citations

Human Vκ immunoglobulin gene number: Implications for the origin of antibody diversity

1981 • 111 citations

Immunoglobulin genes of different subgroups are interdigitated within the V_Klocus

1984 • 110 citations

Organization and evolution of a gene cluster for human immunoglobulin variable regions of the kappa type

1984 • 107 citations

Expression of a cross-reactive idiotype on rheumatoid factor in patients with Sjogren's syndrome.

1986 • 106 citations

Antibodies to shared idiotypes as agents for analysis and therapy for human B cell tumors

1986 • 97 citations

Complete amino acid sequence of variable domains from two monoclonal human anti-gamma globulins of the Wa cross-idiotypic group: suggestion that the J segments are involved in the structural correlate of the idiotype.

1981 • 86 citations

Activation of human B cells and inhibition of their terminal differentiation by monoclonal anti-mu antibodies.

1985 • 82 citations

Expression of three cross-reactive idiotypes on rheumatoid factor autoantibodies from patients with autoimmune diseases and seropositive adults.

1986 • 82 citations

Most κ immunoglobulin mRNA in human lymphocytes is homologous to a small family of germ-line V genes

1984 • 75 citations

Contribution of human VκII germ-line genes to light-chain diversity

1984 • 65 citations

Somatic Mutation in Genes for the Variable Portion of the Immunoglobulin Heavy Chain

1982 • 60 citations

Sequence similarities among kappa IIIb chains of monoclonal human IgM kappa autoantibodies.

1984 • 59 citations

Idiotype variant cell populations in patients with B cell lymphoma.

1986 • 52 citations

Cloning and sequence determination of a human rheumatoid factor light-chain gene.

1986 • 47 citations

Two different rheumatoid factor-producing cell populations distinguished by the mouse erythrocyte receptor and responsiveness to polyclonal B cell activators.

1983 • 46 citations

Structural similarities in the kappa light chains of human rheumatoid factor paraproteins and serum immunoglobulins bearing a cross-reactive idiotype.

1985 • 22 citations

Genetic analysis of human B cell hybridomas expressing a cross-reactive idiotype.

1987 • 15 citations