ADAM17 mRNA expression and pathological features of hepatocellular carcinoma

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

Global cancer statistics in the year 2000

2001 • 2,471 citations

An Essential Role for Ectodomain Shedding in Mammalian Development

1998 • 1,607 citations

A Novel Proteolytic Cleavage Involved in Notch Signaling

2000 • 1,080 citations

Tumor Necrosis Factor-α-converting Enzyme (ADAM17) Mediates the Cleavage and Shedding of Fractalkine (CX3CL1)

2001 • 623 citations

Functional Analysis of the Domain Structure of Tumor Necrosis Factor-α Converting Enzyme

2000 • 496 citations

Multiple Actions of the Chemokine CXCL12 on Epithelial Tumor Cells in Human Ovarian Cancer

2002 • 471 citations

Tumor Necrosis Factor-α Converting Enzyme (TACE) Regulates Epidermal Growth Factor Receptor Ligand Availability

2002 • 415 citations

Evidence for a Role of a Tumor Necrosis Factor-α (TNF-α)-converting Enzyme-like Protease in Shedding of TRANCE, a TNF Family Member Involved in Osteoclastogenesis and Dendritic Cell Survival

1999 • 414 citations

TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells

2003 • 342 citations

Tumor necrosis factor-α converting enzyme

2002 • 341 citations

Tumor Necrosis Factor-α-converting Enzyme Is Required for Cleavage of erbB4/HER4

2000 • 310 citations

Combined transcriptome and genome analysis of single micrometastatic cells

2002 • 301 citations

Expression and clinical significance of erb-B receptor family in hepatocellular carcinoma

2001 • 288 citations

TACE is required for the activation of the EGFR by TGF-α in tumors

2003 • 270 citations

Cleavage and Shedding of E-cadherin after Induction of Apoptosis

2001 • 269 citations

Tumor Necrosis Factor-α Converting Enzyme/ADAM 17 Mediates MUC1 Shedding

2003 • 197 citations

Overexpression of orphan G-protein–coupled receptor, Gpr49, in human hepatocellular carcinomas with β-catenin mutations

2003 • 196 citations

ADAM12 in human liver cancers: TGF-β-regulated expression in stellate cells is associated with matrix remodeling

2003 • 195 citations

Role of Src Kinases in the ADAM-mediated Release of L1 Adhesion Molecule from Human Tumor Cells

2000 • 186 citations

TACE/ADAM17 Processing of EGFR Ligands Indicates a Role as a Physiological Convertase

2003 • 178 citations

Tobacco Smoke-induced Lung Cell Proliferation Mediated by Tumor Necrosis Factor α-converting Enzyme and Amphiregulin

2003 • 172 citations

Selection Criteria for Hepatic Resection in Patients with Large Hepatocellular Carcinoma Larger Than 10 Cm in Diameter1

2002 • 165 citations

Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-α converting enzyme

2001 • 143 citations

Hepatocyte growth factor, transforming growth factor α, and their receptors as combined markers of prognosis in hepatocellular carcinoma

2003 • 122 citations

ADAM12/Syndecan-4 Signaling Promotes β1Integrin-dependent Cell Spreading through Protein Kinase Cα and RhoA

2003 • 111 citations

Expression of Members of the Novel Membrane Linked Metalloproteinase Family ADAM in Cells Derived from a Range of Haematological Malignancies

1997 • 102 citations

Shedding of membrane proteins by ADAM family proteases

2002 • 96 citations

Management of hepatocellular carcinoma.

2003 • 91 citations

ADAMs(A Disintegrin and Metalloproteinase) Messenger RNA Expression inHelicobacter pylori–Infected, Normal, and Neoplastic Gastric Mucosa

2002 • 90 citations

Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-α converting enzyme

2001 • 88 citations

The expression of the ADAMs proteases in prostate cancer cell lines and their regulation by dihydrotestosterone

2000 • 82 citations

Metalloprotease-mediated GH Receptor Proteolysis and GHBP Shedding

2002 • 80 citations

Is surgery for large hepatocellular carcinoma justified?

1999 • 69 citations

ADAM17 but Not ADAM10 Mediates Tumor Necrosis Factor-α and L-Selectin Shedding from Leukocyte Membranes

2001 • 68 citations

Expressions of epidermal growth factor family and its receptor in hepatocellular carcinoma cell lines: relationship to cell proliferation.

1999 • 67 citations

Functional and biochemical characterization of ADAMs and their predicted role in protein ectodomain shedding

2002 • 67 citations

Soluble and cell surface receptors for tumor necrosis factor

1992 • 66 citations

Metalloproteinase Shedding of Fas Ligand Regulates β-Amyloid Neurotoxicity

2002 • 62 citations

Chemotactic agents induce IL-6Rα shedding from polymorphonuclear cells: involvement of a metalloproteinase of the TNF-α-converting enzyme (TACE) type

2002 • 59 citations

The interaction between ADAM 22 and 14-3-3ζ: regulation of cell adhesion and spreading

2003 • 33 citations

Malignant transformation andEGFR activation of immortalized mouse liver epithelial cells caused by HBV enhancer-X from a human hepatocellular carcinoma

2000 • 25 citations

Molecular cloning and expression analysis of a novel member of the Disintegrin and Metalloprotease-Domain (ADAM) family

2002 • 19 citations