Accessory protein regulation of microtubule dynamics throughout the cell cycle

MICROTUBULE POLYMERIZATION DYNAMICS

1997 • 2,442 citations

Dynamic instability of individual microtubules analyzed by video light microscopy: rate constants and transition frequencies.

1988 • 985 citations

Identification of a Protein That Interacts with Tubulin Dimers and Increases the Catastrophe Rate of Microtubules

1996 • 651 citations

XKCM1: A Xenopus Kinesin-Related Protein That Regulates Microtubule Dynamics during Mitotic Spindle Assembly

1996 • 539 citations

Actomyosin-based Retrograde Flow of Microtubules in the Lamella of Migrating Epithelial Cells Influences Microtubule Dynamic Instability and Turnover and Is Associated with Microtubule Breakage and Treadmilling

1997 • 470 citations

Regulation of microtubule dynamics by cdc2 protein kinase in cell-free extracts of Xenopus eggs

1990 • 446 citations

Real-time visualization of cell cycle-dependent changes in microtubule dynamics in cytoplasmic extracts

1990 • 444 citations

Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis.

1995 • 379 citations

Katanin, a Microtubule-Severing Protein, Is a Novel AAA ATPase that Targets to the Centrosome Using a WD40-Containing Subunit

1998 • 332 citations

A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle.

1995 • 305 citations

Mitotic Centromere–associated Kinesin Is Important for Anaphase Chromosome Segregation

1998 • 288 citations

Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics.

1995 • 279 citations

Oncoprotein 18 is a phosphorylation-responsive regulator of microtubule dynamics.

1996 • 275 citations

Stathmin: a relay phosphoprotein for multiple signal transduction?

1991 • 273 citations

Poleward kinetochore fiber movement occurs during both metaphase and anaphase-A in newt lung cell mitosis.

1992 • 271 citations

Yeast Kar3 is a minus-end microtubule motor protein that destabilizes microtubules preferentially at the minus ends.

1994 • 271 citations

Rho Guanosine Triphosphatase Mediates the Selective Stabilization of Microtubules Induced by Lysophosphatidic Acid

1998 • 257 citations

Positive feedback interactions between microtubule and actin dynamics during cell motility

1999 • 256 citations

Microtubule Severing by Elongation Factor 1α

1994 • 252 citations

Stathmin: A Tubulin-Sequestering Protein Which Forms a Ternary T₂S Complex with Two Tubulin Molecules

1997 • 238 citations

The Stathmin/Tubulin Interaction in Vitro

1997 • 218 citations

Mal3, the Fission Yeast Homologue of the Human APC-interacting Protein EB-1 Is Required for Microtubule Integrity and the Maintenance of Cell Form

1997 • 215 citations

XMAP from Xenopus eggs promotes rapid plus end assembly of microtubules and rapid microtubule polymer turnover.

1994 • 209 citations

Protein phosphatase type 1 in mammalian cell mitosis: chromosomal localization and involvement in mitotic exit.

1992 • 198 citations

Observation and quantification of individual microtubule behavior in vivo: microtubule dynamics are cell-type specific.

1993 • 197 citations

Microtubule dynamics at the G2/M transition: abrupt breakdown of cytoplasmic microtubules at nuclear envelope breakdown and implications for spindle morphogenesis.

1996 • 197 citations

Severing of stable microtubules by a mitotically activated protein in xenopus egg extracts

1991 • 196 citations

Distinct roles of PP1 and PP2A-like phosphatases in control of microtubule dynamics during mitosis

1997 • 191 citations

Control of Microtubule Dynamics by Oncoprotein 18: Dissection of the Regulatory Role of Multisite Phosphorylation during Mitosis

1997 • 189 citations

Differential Subcellular Localization of Protein Phosphatase-1 α, γ1, and δ Isoforms during Both Interphase and Mitosis in Mammalian Cells

1998 • 187 citations

BIM1Encodes a Microtubule-binding Protein in Yeast

1997 • 179 citations

The TOGp protein is a new human microtubule-associated protein homologous to the Xenopus XMAP215

1998 • 178 citations

Dissociation of the Tubulin-sequestering and Microtubule Catastrophe-promoting Activities of Oncoprotein 18/Stathmin

1999 • 177 citations

ZYG-9, A Caenorhabditis elegans Protein Required for Microtubule Organization and Function, Is a Component of Meiotic and Mitotic Spindle Poles

1998 • 173 citations

Stu2p: A Microtubule-Binding Protein that Is an Essential Component of the Yeast Spindle Pole Body

1997 • 164 citations

p93dis1, which is required for sister chromatid separation, is a novel microtubule and spindle pole body-associating protein phosphorylated at the Cdc2 target sites.

1995 • 151 citations

Focusing on spindle poles

1998 • 143 citations

The pool of map kinase associated with microtubules is small but constitutively active.

1996 • 142 citations

The Microtubule-destabilizing Activity of Metablastin (p19) Is Controlled by Phosphorylation

1997 • 140 citations

Regulation of Microtubule Dynamics by Ca²⁺/Calmodulin-Dependent Kinase IV/Gr-Dependent Phosphorylation of Oncoprotein 18

1997 • 132 citations

Mitotic chromatin regulates phosphorylation of Stathmin/Op18

1997 • 131 citations

The Saccharomyces cerevisiae Kinesin-related Motor Kar3p Acts at Preanaphase Spindle Poles to Limit the Number and Length of Cytoplasmic Microtubules

1997 • 127 citations

Cytoplasmic assembly of microtubules in cultured cells

1997 • 117 citations

Katanin Is Responsible for the M-Phase Microtubule-severing Activity inXenopusEggs

1998 • 115 citations

G2/M Transition Requires Multisite Phosphorylation of Oncoprotein 18 by Two Distinct Protein Kinase Systems

1995 • 112 citations

Phosphorylation regulates the microtubule‐destabilizing activity of stathmin and its interaction with tubulin

1997 • 97 citations

How the transition frequencies of microtubule dynamic instability (nucleation, catastrophe, and rescue) regulate microtubule dynamics in interphase and mitosis: analysis using a Monte Carlo computer simulation.

1993 • 95 citations

Overexpression of full- or partial-length MAP4 stabilizes microtubules and alters cell growth

1997 • 94 citations

Effect on microtubule dynamics of XMAP230, a microtubule-associated protein present in Xenopus laevis eggs and dividing cells [published erratum appears in J Cell Biol 1995 Mar;128(5):following 988]

1994 • 87 citations

Influence of M-phase chromatin on the anisotropy of microtubule asters.

1996 • 85 citations

Non-centrosomal microtubule formation and measurement of minus end microtubule dynamics in A498 cells

1997 • 83 citations

Quantitative determination of the proportion of microtubule polymer present during the mitosis-interphase transition

1994 • 76 citations

Stable expression of heterologous microtubule-associated proteins (MAPs) in Chinese hamster ovary cells: evidence for differing roles of MAPs in microtubule organization.

1994 • 75 citations

Removal of MAP4 from microtubules in vivo produces no observable phenotype at the cellular level.

1996 • 71 citations

XMAP310: A Xenopus Rescue-promoting Factor Localized to the Mitotic Spindle

1997 • 63 citations

12 Confocal Immunofluorescence Microscopy of Microtubules, Microtubule-Associated Proteins, and Microtubule-Organizing Centers during Amphibian Oogenesis and Early Development

1996 • 56 citations

Mapmodulin: A possible modulator of the interaction of microtubule-associated proteins with microtubules

1997 • 55 citations

Microtubule assembly in clarifiedXenopus egg extracts

1997 • 53 citations

A novel homo-oligomeric protein responsible for an MPF-dependent microtubule-severing activity.

1992 • 51 citations

Microinjection of intact MAP-4 and fragments induces changes of the cytoskeleton in PtK2 cells

1996 • 23 citations

Stepwise Reconstitution of Interphase Microtubule Dynamics in Permeabilized Cells and Comparison to Dynamic Mechanisms in Intact Cells

1998 • 18 citations