CD34+ cells from mobilized peripheral blood retain fetal bone marrow repopulating capacity within the Thy-1+ subset following cell division ex vivo

Determination of lymphocyte division by flow cytometry

1994 • 1,712 citations

Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection.

1990 • 1,465 citations

Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo

1994 • 1,138 citations

Isolation of a candidate human hematopoietic stem-cell population.

1992 • 1,098 citations

c-kit Ligand and Flt3 Ligand: Stem/Progenitor Cell Factors With Overlapping Yet Distinct Activities

1998 • 722 citations

Thrombopoietin: the primary regulator of platelet production [see comments]

1995 • 691 citations

Expression of Thy-1 on human hematopoietic progenitor cells.

1993 • 477 citations

Extensive Amplification and Self-Renewal of Human Primitive Hematopoietic Stem Cells From Cord Blood

1997 • 464 citations

Quantitative Analysis Reveals Expansion of Human Hematopoietic Repopulating Cells After Short-term Ex Vivo Culture

1997 • 424 citations

Self-renewal of primitive human hematopoietic cells (long-term-culture-initiating cells) in vitro and their expansion in defined medium.

1996 • 393 citations

Differential cytokine effects on primitive (CD34+CD38-) human hematopoietic cells: novel responses to Flt3-ligand and thrombopoietin.

1996 • 360 citations

Multi-level effects of flt3 ligand on human hematopoiesis: expansion of putative stem cells and proliferation of granulomonocytic progenitors/monocytic precursors

1995 • 240 citations

Flt3 ligand induces proliferation of quiescent human bone marrow CD34+CD38- cells and maintains progenitor cells in vitro

1996 • 240 citations

Thrombopoietin supports proliferation of human primitive hematopoietic cells in synergy with steel factor and/or interleukin-3

1996 • 220 citations

Enrichment of human hematopoietic stem cell activity in the CD34+Thy- 1+Lin- subpopulation from mobilized peripheral blood

1995 • 205 citations

Ability of Early Acting Cytokines to Directly Promote Survival and Suppress Apoptosis of Human Primitive CD34+CD38− Bone Marrow Cells With Multilineage Potential at the Single-Cell Level: Key Role of Thrombopoietin

1997 • 201 citations

The Unexpected G0/G1 Cell Cycle Status of Mobilized Hematopoietic Stem Cells From Peripheral Blood

1997 • 191 citations

Thrombopoietin, kit Ligand, and flk2/flt3 Ligand Together Induce Increased Numbers of Primitive Hematopoietic Progenitors From Human CD34+Thy-1+Lin− Cells With Preserved Ability to Engraft SCID-hu Bone

1998 • 170 citations

Ability of Early Acting Cytokines to Directly Promote Survival and Suppress Apoptosis of Human Primitive CD34+CD38− Bone Marrow Cells With Multilineage Potential at the Single-Cell Level: Key Role of Thrombopoietin

1997 • 169 citations

Effect of flt3 ligand on the ex vivo expansion of human CD34+ hematopoietic progenitor cells

1995 • 159 citations

Thrombopoietin directly and potently stimulates multilineage growth and progenitor cell expansion from primitive (CD34+ CD38-) human bone marrow progenitor cells: distinct and key interactions with the ligands for c-kit and flt3, and inhibitory effects of TGF-beta and TNF-alpha.

1997 • 149 citations

Long-term generation and expansion of human primitive hematopoietic progenitor cells in vitro

1993 • 135 citations

Differential growth factor requirement of primitive cord blood hematopoietic stem cell for self-renewal and amplification vs proliferation and differentiation

1998 • 130 citations

Thrombopoietin stimulates megakaryocytopoiesis, myelopoiesis, and expansion of CD34+ progenitor cells from single CD34+Thy-1+Lin- primitive progenitor cells

1996 • 129 citations

Human fetal bone marrow early progenitors for T, B, and myeloid cells are found exclusively in the population expressing high levels of CD34

1994 • 122 citations

Stem Cell Factor as a Survival and Growth Factor in Human Normal and Malignant Hematopoiesis

1996 • 118 citations

Cycling Status of CD34+ Cells Mobilized Into Peripheral Blood of Healthy Donors by Recombinant Human Granulocyte Colony-Stimulating Factor

1997 • 115 citations

Increased Recruitment of Hematopoietic Progenitor Cells Underlies the Ex Vivo Expansion Potential of FLT3 Ligand

1997 • 104 citations

Hematopoietic potential of cryopreserved and ex vivo manipulated umbilical cord blood progenitor cells evaluated in vitro and in vivo

1996 • 104 citations

High‐resolution cell division tracking demonstrates the Flt3‐ligand‐dependence of human marrow CD34⁺CD38⁻ cell production in vitro

1997 • 100 citations

Proliferation-induced decline of primitive hematopoietic progenitor cell activity is coupled with an increase in apoptosis of ex vivo expanded CD34+ cells.

1998 • 81 citations

Rescue from apoptosis in early (CD34-selected) versus late (non-CD34-selected) human hematopoietic cells by very late antigen 4- and vascular cell adhesion molecule (VCAM) 1-dependent adhesion to bone marrow stromal cells.

1998 • 54 citations

Characterization of Cell Cycle Status and E2F Complexes in Mobilized CD34+ Cells Before and After Cytokine Stimulation

1997 • 50 citations

Accelerated cell-cycling of hematopoietic progenitors by the flt3 ligand that is modulated by transforming growth factor-beta

1996 • 49 citations

Flt3 Ligand Enhances the Yield of Primitive Cells After Ex Vivo Cultivation of CD34+ CD38dim Cells and CD34+ CD38dim CD33dim HLA-DR+ Cells

1997 • 34 citations

Analysis of human hematopoietic stem cell populations.

1994 • 32 citations

FUNCTION OF PORCINE ADHESION MOLECULES IN A HUMAN MARROW MICROENVIRONMENT1

1998 • 20 citations

Thrombopoietin, a Direct Stimulator of Viability and Multilineage Growth of Primitive Bone Marrow Progenitor Cells

1996 • 16 citations

Hematopoietic stem cell expansion

1997 • 11 citations

Quantitation of the proliferative potential of highly enriched human primitive hematopoietic progenitor cells using a stroma-free limiting dilution assay with automated scoring

1999 • 1 citations

Deleted Work

1955 • 0 citations