CD4 T cells can reject major histocompatibility complex class I-incompatible skin grafts

Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists.

1993 • 837 citations

IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses.

1988 • 731 citations

REMISSION INDUCTION IN NON-HODGKIN LYMPHOMA WITH RESHAPED HUMAN MONOCLONAL ANTIBODY CAMPATH-1H

1988 • 703 citations

Migration and maturation of Langerhans cells in skin transplants and explants.

1990 • 663 citations

The behaviour and fate of skin autografts and skin homografts in rabbits: A report to the War Wounds Committee of the Medical Research Council.

1944 • 661 citations

Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages.

1990 • 511 citations

Monoclonal antibody to the murine type 3 complement receptor inhibits adhesion of myelomonocytic cells in vitro and inflammatory cell recruitment in vivo.

1987 • 370 citations

CELLS MEDIATING ALLOGRAFT REJECTION

1991 • 330 citations

CD4+ but not CD8+ cells are essential for allorejection.

1996 • 303 citations

Cellular Basis of Skin Allograft Rejection: An In Vivo Model of Immune-Mediated Tissue Destruction

1992 • 295 citations

Clearance of adenovirus-infected hepatocytes by MHC class I-restricted CD4+ CTLs in vivo.

1995 • 269 citations

Monoclonal antibodies that define canine homologues of human CD antigens: Summary of the First International Canine Leukocyte Antigen Workshop (CLAW)

1994 • 247 citations

T cell suppression in transplantation tolerance through linked recognition.

1996 • 246 citations

Rejection of skin allografts by indirect allorecognition of donor class I major histocompatibility complex peptides.

1992 • 218 citations

Mouse epidermal Ia molecules have a bone marrow origin

1979 • 203 citations

Phenotype, specificity, and function of T cell subsets and T cell interactions involved in skin allograft rejection.

1987 • 198 citations

IN VIVO DEPLETION OF CD8+ T CELLS RESULTS IN Th2 CYTOKINE PRODUCTION AND ALTERNATE MECHANISMS OF ALLOGRAFT REJECTION

1995 • 190 citations

BIOCHEMISTRY OF THE GENE PRODUCTS FROM MURINE MHC MUTANTS

1980 • 182 citations

CD4 monoclonal antibody pairs for immunosuppression and tolerance induction

1987 • 173 citations

Skin graft rejection by beta 2-microglobulin-deficient mice.

1992 • 142 citations

Properties of purified T cell subsets. I. In vitro responses to class I vs. class II H-2 alloantigens.

1985 • 137 citations

Analysis of T-cell subsets in rejection of Kb mutant skin allografts differing at class I MHC

1986 • 114 citations

"Intrinsic" Immunological Tolerance in Allophenic Mice

1967 • 109 citations

Role of T cell subsets in lethal graft-versus-host disease (GVHD) directed to class I versus class II H-2 differences. I. L3T4+ cells can either augment or retard GVHD elicited by Lyt-2+ cells in class I different hosts.

1988 • 104 citations

Adoptive T cell transfer of autoimmune nonobese diabetic mouse diabetes does not require recruitment of host B lymphocytes.

1988 • 92 citations

Role of accessory cell processing and presentation of shed H-2 alloantigens in allospecific cytotoxic T lymphocyte responses.

1984 • 87 citations

FAS-MEDIATED CYTOTOXICITY AN IMMUNOEFFECTOR OR IMMUNOREGULATORY PATHWAY IN T CELL-MEDIATED IMMUNE RESPONSES?

1995 • 84 citations

T cell requirements for the rejection of renal allografts bearing an isolated class I MHC disparity.

1990 • 80 citations

Cellular basis of skin allograft rejection across a class I major histocompatibility barrier in mice depleted of CD8+ T cells in vivo.

1991 • 76 citations

CD4-POSITIVE HELPER T LYMPHOCYTES MEDIATE MOUSE CARDIAC ALLOGRAFT REJECTION INDEPENDENT OF DONOR ALLOANTIGEN SPECIFIC CYTOTOXIC T LYMPHOCYTES

1993 • 75 citations

Adoptively transferred CD4+ lymphocytes from CD8 -/- mice are sufficient to mediate the rejection of MHC class II or class I disparate skin grafts.

1996 • 72 citations

HISTOCOMPATIBILITY ANTIGENS ON MELANOBLASTS AND HAIR FOLLICLE CELLS

1970 • 69 citations

CD4⁺ T cell‐mediated rejection of major histocompatibility complex class I‐disparate grafts: A role for alloantibody

1993 • 61 citations

Profound atrophy of the bone marrow reflecting major histocompatibility complex class II-restricted destruction of stem cells by CD4+ cells.

1994 • 60 citations

INDUCTION OF Ia ANTIGENS ON MURINE EPIDERMAL CELLS DURING THE REJECTION OF SKIN ALLOGRAFTS

1983 • 59 citations

Classical transplantation tolerance in the adult: the interaction between myeloablation and immunosuppression

1992 • 59 citations

THE ROLE OF HOST T CELL SUBSETS IN BONE MARROW REJECTION DIRECTED TO ISOLATED MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I VERSUS CLASS II DIFFERENCES OF bm1 and bm12 MUTANT MICE1,2

1994 • 51 citations

Specific prolongation of MHC class II disparate skin allografts by in vivo administration of anti-IFN-gamma monoclonal antibody.

1990 • 51 citations

ACUTE REJECTION OF CARDIAC ALLOGRAFTS BY NONCYTOLYTIC CD4+ T CELL POPULATIONS1

1996 • 50 citations

OKT4+ cytotoxic T cells can lyse targets via class I molecules and can be blocked by monoclonal antibody against T4 molecules.

1984 • 49 citations

Effector cells in allelic H-2 class I-incompatible skin graft rejection.

1987 • 42 citations

Mononuclear phagocytes: a major population of effector cells responsible for rejection of allografted tumor cells in mice.

1991 • 40 citations

Ca2+-dependent, Fas- and perforin-independent apoptotic death of allografted tumor cells by a type of activated macrophage.

1997 • 39 citations

The functional significance of two amino acid polymorphisms in the antigen-presenting domain of class I MHC molecules. Molecular dissection of Kbm3.

1989 • 36 citations

Failure to Reject an Allografted Tumor after Elimination of Macrophages in Mice

1996 • 36 citations

Tolerance and MHC restriction in transgenic mice expressing a MHC class I gene in erythroid cells

1992 • 35 citations

Analysis of effector mechanisms in murine cardiac allograft rejection

1996 • 31 citations

THE ROLE OF T4+ AND LY-2+ CELLS IN SKIN GRAFT REJECTION IN THE MOUSE

1987 • 28 citations

THE ROLE OF CD8+ AND CD4+ CELLS IN ISLET ALLOGRAFT REJECTION

1990 • 28 citations

CD4+ T CELLS ARE ABLE TO REJECT CLASS I DISPARATE ALLOGRAFTS1

1997 • 27 citations

Heterogenous graft rejection pathways in class I major histocompatibility complex-disparate combinations and their differential susceptibility to immunomodulation induced by intravenous presensitization with relevant alloantigens.

1991 • 25 citations

Rejection of skin allografts by CD4+ T cells is antigen-specific and requires expression of target alloantigen on Ia- epidermal cells.

1989 • 22 citations

CD4‐negative cytotoxic T cells with a T cell receptor α/β^intermediate expression in CD8‐deficient mice

1996 • 22 citations

Differential involvement of CD4+ cells in mediating skin graft rejection against different amounts of transgenic H-2K(b) antigen.

1991 • 20 citations

Immunologically nonspecific mechanisms of tissue destruction in the rejection of skin grafts.

1994 • 20 citations

Transplantation tolerance with monoclonal antibodies.

1990 • 20 citations

Amino acid changes in the peptide binding site have structural consequences at the surface of class I glycoproteins.

1993 • 18 citations

Induction of anti-CD8 resistant cytotoxic T lymphocytes by anti-CD8 antibodies. Functional evidence for T cell signaling induced by multi-valent cross-linking of CD8 on precursor cells.

1988 • 13 citations

ALLOGRAFT REJECTION IN ATHYMIC NUDE RATS BY TRANSFERRED T CELL SUBSETS

1990 • 12 citations

Deleted Work

1955 • 0 citations

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