Mouse Skin as a Model for Cancer Chemoprevention by Nonsteroidal Anti-Inflammatory Drugs

Hepatogastroenterology

2011 • 2,829 citations

CYCLOOXYGENASES 1 AND 2

1998 • 2,700 citations

The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous Polyposis

2000 • 2,505 citations

Prostanoid Receptors: Structures, Properties, and Functions

1999 • 2,395 citations

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

1996 • 2,387 citations

Treatment of Colonic and Rectal Adenomas with Sulindac in Familial Adenomatous Polyposis

1993 • 1,739 citations

The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

1998 • 1,561 citations

Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors.

2000 • 1,310 citations

The Epidemiology of Skin Cancer

1996 • 1,245 citations

Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs

1997 • 1,106 citations

Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2

2001 • 1,063 citations

Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis.

1998 • 933 citations

Expression of cyclooxygenase-2 in human gastric carcinoma.

1997 • 829 citations

Overexpression of Cyclooxygenase-2 Is Sufficient to Induce Tumorigenesis in Transgenic Mice

2001 • 809 citations

Cyclooxygenase‐independent actions of cyclooxygenase inhibitors

2001 • 742 citations

Expression of cyclooxygenase-2 in human lung carcinoma.

1998 • 729 citations

Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck.

1999 • 722 citations

Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer.

1999 • 692 citations

Cyclooxygenase-2 expression in human esophageal carcinoma.

1999 • 670 citations

Expression of Cyclooxygenase-1 and Cyclooxygenase-2 in Human Breast Cancer

1998 • 665 citations

Multistage carcinogenesis in mouse skin

1992 • 647 citations

Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway

1996 • 613 citations

COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer

1998 • 596 citations

Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas.

1998 • 595 citations

Acceleration of intestinal polyposis through prostaglandin receptor EP2 in ApcΔ716 knockout mice

2001 • 585 citations

Chemoprevention of Colorectal Cancer

2000 • 502 citations

Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor.

2000 • 494 citations

The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the min mouse model of adenomatous polyposis.

2000 • 481 citations

Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis.

2000 • 462 citations

Cyclooxygenase 2 is induced in colonic epithelial cells in inflammatory bowel disease

1998 • 454 citations

Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis

1999 • 413 citations

Expression of cyclooxygenase-2 in human hepatocellular carcinoma: Relevance to tumor dedifferentiation

1999 • 399 citations

Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis.

2002 • 372 citations

Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis.

1999 • 363 citations

Colorectal Cancer and Nonsteroidal Anti-inflammatory Drugs

1997 • 355 citations

Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis.

2002 • 345 citations

Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition

1999 • 334 citations

Cyclooxygenase-2 is overexpressed in human cervical cancer.

2001 • 330 citations

Celecoxib prevents tumor growth in vivo without toxicity to normal gut: lack of correlation between in vitro and in vivo models.

2000 • 320 citations

Expression of cyclooxygenase-2 in prostate carcinoma

2000 • 319 citations

Cyclooxygenase-2 expression in human gliomas: prognostic significance and molecular correlations.

2001 • 303 citations

Sodium salicylate induces apoptosis via p38 mitogen-activated protein kinase but inhibits tumor necrosis factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activation

1997 • 282 citations

Lipoxygenase modulation to reverse carcinogenesis.

2001 • 271 citations

Malignant Transformation and Antineoplastic Actions of Nonsteroidal Antiinflammatory Drugs (Nsaids) on Cyclooxygenase-Null Embryo Fibroblasts

1999 • 269 citations

Celecoxib inhibits N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced urinary bladder cancers in male B6D2F1 mice and female Fischer-344 rats.

2000 • 263 citations

Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis

2002 • 246 citations

Cyclooxygenase knockout mice

1999 • 224 citations

Topical treatment of actinic keratoses with 3·0% diclofenac in 2·5% hyaluronan gel

2002 • 212 citations

Cyclooxygenase 2 inhibitors: discovery, selectivity and the future

1999 • 211 citations

Dihydroxy Bile Acids Activate the Transcription of Cyclooxygenase-2

1998 • 210 citations

Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin

2001 • 201 citations

Activation of p38 Mitogen-Activated Protein Kinase by Sodium Salicylate Leads to Inhibition of Tumor Necrosis Factor-Induced IκBα Phosphorylation and Degradation

1998 • 196 citations

Nested case–control study of the effects of non-steroidal anti-inflammatory drugs on breast cancer risk and stage

2000 • 186 citations

Cyclooxygenase-2 expression in hepatocellular carcinoma.

1999 • 175 citations

Loss of ceramide production confers resistance to radiation-induced apoptosis.

1997 • 162 citations

Expression of Cyclooxygenase-2 in Human Transitional Cell Carcinoma of the Urinary Bladder

2001 • 149 citations

Differential expression of prostaglandin h synthase isozymes during multistage carcinogenesis in mouse epidermis

1995 • 149 citations

Inhibition of Ultraviolet B-induced Activator Protein-1 (AP-1) Activity by Aspirin in AP-1-Luciferase Transgenic Mice

1997 • 146 citations

Expression of cyclooxygenase-2 mRNA in active inflammatory bowel disease.

1997 • 142 citations

Early expression of cyclo-oxygenase-2 during sporadic colorectal carcinogenesis

1999 • 134 citations

PEA3 Is Up-regulated in Response to Wnt1 and Activates the Expression of Cyclooxygenase-2

2001 • 133 citations

Eicosanoids and multistage carcinogenesis in NMRI mouse skin: role of prostaglandins E and F in conversion (first stage of tumor promotion) and promotion (second stage of tumor promotion)

1989 • 121 citations

Inhibitory effect of a prostaglandin E receptor subtype EP1 selective antagonist, ONO-8713, on development of azoxymethane-induced aberrant crypt foci in mice

2000 • 121 citations

Prostaglandin-H-synthase isozyme expression in normal and neoplastic human skin

1999 • 119 citations

Increased expression of cyclooxygenase-2 protein in 4-nitroquinoline-1-oxide-induced rat tongue carcinomas and chemopreventive efficacy of a specific inhibitor, nimesulide.

2001 • 116 citations

Localization of prostaglandin H synthase isoenzymes in murine epidermal tumors: Suppression of skin tumor promotion by inhibition of prostaglandin H synthase-2

1998 • 112 citations

Cancer chemoprevention through interruption of multistage carcinogenesis

2000 • 111 citations

Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor)

2001 • 107 citations

A Selective Cyclooxygenase‐2 Inhibitor Suppresses Tumor Growth in Nude Mouse Xenografted with Human Head and Neck Squamous Carcinoma Cells

1999 • 104 citations

Expression of cyclooxygenase-2 in human squamous cell carcinoma of the esophagus; an immunohistochemical survey.

1999 • 95 citations

Helicobacter pylori infection induces cyclooxygenase-2 expression in human gastric mucosa

1998 • 95 citations

Is inhibition of cyclooxygenase required for the chemopreventive effect of NSAIDs in colon cancer? A model reconciling the current contradiction

2000 • 86 citations

Aberrant cyclooxygenase isozyme expression in human intrahepatic cholangiocarcinoma

2001 • 82 citations

Cyclooxygenase-2 upregulation as a perigenetic change in carcinogenesis.

2001 • 79 citations

Clinical and genomic influence of sulindac on rectal mucosa in familial adenomatous polyposis

1997 • 76 citations

The Effects of Cyclooxygenase Isozyme Inhibition onIncisional Wound Healing in Mouse Skin

2002 • 70 citations

Differential expression of prostaglandin-H synthase isoenzymes in normal and activated keratinocytes in vivo and in vitro

1995 • 63 citations

Expression and localization of cyclo-oxygenase isoforms in non-small cell lung cancer

1999 • 45 citations

Metabolic Targets of Cancer Chemoprevention: Interruption of Tumor Development by Inhibitors of Arachidonic Acid Metabolism

1999 • 43 citations

Cellular localization of cyclo-oxygenase isozymes in Crohn's disease and colorectal cancer

1999 • 31 citations

Lack of Cyclooxygenase-2 Inhibits Growth of Teratocarcinomas in Mice

2000 • 26 citations

Tumor Promotion in Skin

1995 • 20 citations

Chemoprevention of intestinal polyposis in the APCΔ716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor

2000 • 12 citations

Krebs- und Alzheimer-Prävention mit nicht-steroidalen Entzündungshemmern

2001 • 2 citations