Dihydroxy Bile Acids Activate the Transcription of Cyclooxygenase-2

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Rapid colorimetric assay for cell growth and survival

1986 • 4,672 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

1996 • 2,387 citations

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

1991 • 2,362 citations

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1995 • 2,308 citations

Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2

1996 • 1,987 citations

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

Treatment of Colonic and Rectal Adenomas with Sulindac in Familial Adenomatous Polyposis

1993 • 1,739 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential

1997 • 1,411 citations

Transcription factor AP-2 mediates induction by two different signal-transduction pathways: Protein kinase C and cAMP

1987 • 1,391 citations

Protein kinase Cα activates RAF-1 by direct phosphorylation

1993 • 1,282 citations

Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer.

1995 • 837 citations

Expression of cyclooxygenase-2 in human gastric carcinoma.

1997 • 829 citations

Promoting Effect of Bile Acids on Colon Carcinogenesis After Intrarectal Instillation of N -Methyl- N ′ nitro- N -nitrosoguanidine in Rats 2

1974 • 717 citations

Regulation of the immune response by prostaglandins

1983 • 717 citations

Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines.

1993 • 710 citations

A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein.

1991 • 571 citations

Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis.

1996 • 549 citations

Transcriptional Regulation of Human Prostaglandin-endoperoxide Synthase-2 Gene by Lipopolysaccharide and Phorbol Ester in Vascular Endothelial Cells

1995 • 487 citations

Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: evidence for a transcriptional effect.

1996 • 462 citations

Promoting effect of bile acids in colon carcinogenesis in germ-free and conventional F344 rats.

1977 • 436 citations

Transcription of cyclooxygenase-2 is enhanced in transformed mammary epithelial cells.

1996 • 426 citations

Large-Bowel Carcinogenesis: Fecal Constituents of Populations With Diverse Incidence Rates of Colon Cancer2

1973 • 413 citations

Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent.

1995 • 400 citations

Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-alpha and phorbol ester.

1994 • 377 citations

v-src Induces Prostaglandin Synthase 2 Gene Expression by Activation of the c-Jun N-terminal Kinase and the c-Jun Transcription Factor

1995 • 295 citations

Aspirin and reduced risk of esophageal carcinoma

1995 • 290 citations

Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid

1997 • 213 citations

v-src induction of the TIS10/PGS2 prostaglandin synthase gene is mediated by an ATF/CRE transcription response element.

1994 • 207 citations

Self-Promotion? Intimate Connections Between APC and Prostaglandin H Synthase-2

1996 • 203 citations

Implication of duodenogastric reflux in the pathogenesis of Barrett's oesophagus

1988 • 190 citations

Benzo[a]pyrene up-regulates cyclooxygenase-2 gene expression in oral epithelial cells

1997 • 154 citations

Retinoids suppress epidermal growth factor-induced transcription of cyclooxygenase-2 in human oral squamous carcinoma cells.

1997 • 146 citations

Factors in the mechanism of diarrhea in bile acid malabsorption: Fecal pH—A key determinant

1981 • 132 citations

Influence of pancreatic and biliary reflux on the development of esophageal carcinoma

1993 • 120 citations

The regulation of protein kinase C by chenodeoxycholate, deoxycholate and several structurally related bile acids

1987 • 110 citations

Measurement of arachidonate and its metabolites extracted from human normal and malignant gastrointestinal tissues.

1987 • 109 citations

Bile acids, non‐phorbol‐ester‐type tumor promoters, stimulate the phosphorylation of protein kinase C substrates in human platelets and colon cell line HT29

1992 • 99 citations

Retinoids suppress phorbol ester-mediated induction of cyclooxygenase-2.

1997 • 97 citations

The production of prostanoids in human cancers, and their implications for tumor progression

1986 • 89 citations

Antitumoral Activity of Indomethacin on Experimental Esophageal Tumors

1984 • 88 citations

Bile acids and colorectal cancer

1991 • 73 citations

Further studies on the therapeutic effect of indomethacin on esophageal tumors

1986 • 71 citations

Induction of the transcription factor AP-1 in cultured human colon adenocarcinoma cells following exposure to bile acids

1996 • 68 citations

Identification of unconjugated bile acids in human bile.

1990 • 64 citations

Overexpression of protein kinase C-zeta isoform increases cyclooxygenase-2 and inducible nitric oxide synthase

1997 • 55 citations

AP-1 binds to a putative cAMP response element of the MyoD1 promoter and negatively modulates MyoD1 expression in dividing myoblasts.

1994 • 54 citations

Characterization of cell lines established from human gastric-esophageal adenocarcinomas: Biologic phenotype and invasion potential

1993 • 49 citations

Role of Prostaglandins in Bile Salt-Induced Changes in Rat Colonic Structure and Function

1981 • 48 citations

Studies on Protein Kinase C and Colon Carcinogenesis

1987 • 43 citations

Promoting effect of bile acids on the chemical transformation of C3H/10T1/2 fibroblasts in vitro.

1984 • 40 citations