PEA3 Is Up-regulated in Response to Wnt1 and Activates the Expression of Cyclooxygenase-2

β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

1999 • 3,566 citations

Wnt signaling and cancer

2000 • 3,215 citations

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

1994 • 2,553 citations

The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous Polyposis

2000 • 2,505 citations

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

1996 • 2,387 citations

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1995 • 2,308 citations

Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells

1998 • 2,282 citations

The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway

1999 • 2,206 citations

Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential

1997 • 1,411 citations

Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors.

2000 • 1,310 citations

Armadillo Coactivates Transcription Driven by the Product of the Drosophila Segment Polarity Gene dTCF

1997 • 1,201 citations

Expression of cyclooxygenase-1 and -2 in human colorectal cancer.

1995 • 1,135 citations

PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs

1999 • 1,091 citations

A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the sam mRNA

1991 • 1,019 citations

Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer.

1995 • 837 citations

Expression of cyclooxygenase-2 in human gastric carcinoma.

1997 • 829 citations

Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas.

1998 • 825 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Overexpression of Cyclooxygenase-2 Is Sufficient to Induce Tumorigenesis in Transgenic Mice

2001 • 809 citations

Biological Role of the CCAAT/Enhancer-binding Protein Family of Transcription Factors

1998 • 799 citations

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

1988 • 745 citations

Expression of cyclooxygenase-2 in human lung carcinoma.

1998 • 729 citations

Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck.

1999 • 722 citations

Host cyclooxygenase-2 modulates carcinoma growth

2000 • 693 citations

The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors

1999 • 679 citations

Transcriptional Roles of Nuclear Factor κB and Nuclear Factor-Interleukin-6 in the Tumor Necrosis Factor α-Dependent Induction of Cyclooxygenase-2 in MC3T3-E1 Cells

1995 • 657 citations

LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein.

1990 • 599 citations

COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer

1998 • 596 citations

Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis.

1996 • 549 citations

Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor.

2000 • 494 citations

Transcriptional Regulation of Human Prostaglandin-endoperoxide Synthase-2 Gene by Lipopolysaccharide and Phorbol Ester in Vascular Endothelial Cells

1995 • 487 citations

Induction of cyclooxygenase-2 by interleukin-1 alpha. Evidence for post-transcriptional regulation.

1994 • 478 citations

Signal transduction by the Wnt family of ligands

1998 • 474 citations

Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis.

2000 • 462 citations

Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis

1999 • 413 citations

Regulation of Wnt Signaling by Sox Proteins

1999 • 342 citations

Transcriptional Activation of the Cyclooxygenase-2 Gene in Endotoxin-treated RAW 264.7 Macrophages

2000 • 339 citations

Molecular cloning and characterization of PEA3, a new member of the Ets oncogene family that is differentially expressed in mouse embryonic cells.

1992 • 338 citations

Ras Pathway Specificity Is Determined by the Integration of Multiple Signal-Activated and Tissue-Restricted Transcription Factors

2000 • 324 citations

Elevated cyclooxygenase-2 levels in Min mouse adenomas

1996 • 311 citations

WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene.

2000 • 302 citations

v-src Induces Prostaglandin Synthase 2 Gene Expression by Activation of the c-Jun N-terminal Kinase and the c-Jun Transcription Factor

1995 • 295 citations

Cyclooxygenase-2 gene expression in human breast cancer

1997 • 274 citations

WISP-1 is a Wnt-1- and β-catenin-responsive oncogene

2000 • 263 citations

Regulation of Constitutive Cyclooxygenase-2 Expression in Colon Carcinoma Cells

2000 • 262 citations

Association between a transmembrane protein tyrosine phosphatase and the cadherin-catenin complex.

1996 • 251 citations

Transcriptional Regulation of Prostaglandin Synthase 2 Gene Expression by Platelet-derived Growth Factor and Serum

1996 • 244 citations

Down-regulation of cytokine-induced cyclo-oxygenase-2 transcript isoforms by dexamethasone: evidence for post-transcriptional regulation

1996 • 235 citations

Ceramide Regulates the Transcription of Cyclooxygenase-2

1998 • 203 citations

Transcriptional Regulation of Cyclooxygenase-2 in Mouse Skin Carcinoma Cells

1998 • 197 citations

Induction of Cyclooxygenase-2 by Activated Ha-rasOncogene in Rat-1 Fibroblasts and the Role of Mitogen-activated Protein Kinase Pathway

1998 • 193 citations

A retrovirus vector expressing the putative mammary oncogene int-1 causes partial transformation of a mammary epithelial cell line

1986 • 189 citations

Transcriptional activation of cyclooxygenase-2 in Wnt-1-transformed mouse mammary epithelial cells.

1999 • 186 citations

The PEA3 Subfamily of Ets Transcription Factors Synergizes with β-Catenin–LEF-1 To Activate Matrilysin Transcription in Intestinal Tumors

2001 • 169 citations

HER2/Neu and the Ets transcription activator PEA3 are coordinately upregulated in human breast cancer

1997 • 152 citations

Transcriptional Regulation of the Cyclooxygenase-2 Gene in Activated Mast Cells

2000 • 122 citations

Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3).

1995 • 111 citations

Regulation of eosinophil-specific gene expression by a C/EBP-Ets complex and GATA-1

1998 • 110 citations

Regulation of Cyclooxygenase-2 and Periostin by Wnt-3 in Mouse Mammary Epithelial Cells

2000 • 108 citations

Significant Roles of Inducible Cyclooxygenase (COX)-2 in Angiogenesis in Rat Sponge Implants.

1997 • 103 citations

The inhibition of colon-26 adenocarcinoma development and angiogenesis by topical diclofenac in 2.5% hyaluronan.

1997 • 81 citations

The effect of selective cyclooxygenase-2 inhibitor on corneal angiogenesis in the rat

1999 • 81 citations

Trunk-specific modulation of Wingless signalling in Drosophila by Teashirt binding to Armadillo

1998 • 75 citations

Molecular characterization of the zebrafish PEA3 ETS-domain transcription factor

1998 • 60 citations

Wnt Signaling Stabilizes the Dual‐Function Protein β‐Catenin in Diverse Cell Types^a

1998 • 55 citations

Significant Roles of Inducible Cyclooxygenase (COX)-2 in Angiogenesis in Rat Sponge Implants

1997 • 28 citations