Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Cancer statistics, 2000

2000 • 3,907 citations

15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

1995 • 2,857 citations

Cyclooxygenases: Structural, Cellular, and Molecular Biology

2000 • 2,837 citations

Identification and characterization of the familial adenomatous polyposis coli gene

1991 • 2,806 citations

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

1994 • 2,553 citations

The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous Polyposis

2000 • 2,505 citations

Cyclooxygenase in biology and disease

1998 • 2,483 citations

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

1996 • 2,387 citations

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1995 • 2,308 citations

Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells

1998 • 2,282 citations

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ

1997 • 2,100 citations

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

1995 • 2,036 citations

Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2

1996 • 1,987 citations

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

Inhibition of NF-κB by Sodium Salicylate and Aspirin

1994 • 1,743 citations

Treatment of Colonic and Rectal Adenomas with Sulindac in Familial Adenomatous Polyposis

1993 • 1,739 citations

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

1991 • 1,734 citations

Aspirin Use and Reduced Risk of Fatal Colon Cancer

1991 • 1,695 citations

The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

1998 • 1,561 citations

A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse

1990 • 1,550 citations

Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene

1992 • 1,510 citations

Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential

1997 • 1,411 citations

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.

1994 • 1,322 citations

Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors.

2000 • 1,310 citations

Inducible cyclooxygenase may have anti-inflammatory properties

1999 • 1,246 citations

Prostaglandin synthase 2

1996 • 1,212 citations

Expression of cyclooxygenase-1 and -2 in human colorectal cancer.

1995 • 1,135 citations

Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells.

1998 • 1,130 citations

Aspirin and the Risk of Colorectal Cancer in Women

1995 • 1,116 citations

Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs

1997 • 1,106 citations

PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs

1999 • 1,091 citations

The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes.

1990 • 940 citations

Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis.

1998 • 933 citations

Role ofBAXin the Apoptotic Response to Anticancer Agents

2000 • 854 citations

Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer.

1995 • 837 citations

Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: Insight into mechanisms and implications for cancer growth and ulcer healing

1999 • 830 citations

Overexpression of Cyclooxygenase-2 Is Sufficient to Induce Tumorigenesis in Transgenic Mice

2001 • 809 citations

Aspirin Use and the Risk for Colorectal Cancer and Adenoma in Male Health Professionals

1994 • 804 citations

Identification of a Gene Located at Chromosome 5q21 that Is Mutated in Colorectal Cancers

1991 • 758 citations

Sulindac causes regression of rectal polyps in familial adenomatous polyposis

1991 • 736 citations

Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2.

1997 • 734 citations

Expression of cyclooxygenase-2 in human lung carcinoma.

1998 • 729 citations

Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck.

1999 • 722 citations

Host cyclooxygenase-2 modulates carcinoma growth

2000 • 693 citations

Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer.

1999 • 692 citations

Expression of Cyclooxygenase-1 and Cyclooxygenase-2 in Human Breast Cancer

1998 • 665 citations

Prostaglandin E2 Increases Growth and Motility of Colorectal Carcinoma Cells

2001 • 659 citations

Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway

1996 • 613 citations

COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer

1998 • 596 citations

Acceleration of intestinal polyposis through prostaglandin receptor EP2 in ApcΔ716 knockout mice

2001 • 585 citations

Different Intracellular Locations for Prostaglandin Endoperoxide H Synthase-1 and −2

1995 • 574 citations

Altered eicosanoid levels in human colon cancer.

1993 • 571 citations

Celecoxib versus diclofenac in long-term management of rheumatoid arthritis: randomised double-blind comparison

1999 • 549 citations

Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis.

1996 • 549 citations

Over-expression of cyclooxygenase-2 in human prostate adenocarcinoma

2000 • 535 citations

Sulindac for polyposis of the colon

1983 • 521 citations

Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice.

2000 • 504 citations

Randomized controlled trial of the effect of sulindac on duodenal and rectal polyposis and cell proliferation in patients with familial adenomatous polyposis

1993 • 494 citations

Combinatorial chemoprevention of intestinal neoplasia

2000 • 492 citations

Sulindac Inhibits Activation of the NF-κB Pathway

1999 • 490 citations

A randomized trial comparing the effect of rofecoxib, a cyclooxygenase 2–specific inhibitor, with that of ibuprofen on the gastroduodenal mucosa of patients with osteoarthritis

1999 • 487 citations

The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the min mouse model of adenomatous polyposis.

2000 • 481 citations

Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis.

2000 • 462 citations

Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: evidence for a transcriptional effect.

1996 • 462 citations

Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors

1996 • 438 citations

Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase-2.

1996 • 427 citations

Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis

1999 • 413 citations

Use of aspirin and other nonsteroidal anti-inflammatory drugs and risk of esophageal and gastric cancer.

1998 • 413 citations

Regulation of fibroblast cyclooxygenase synthesis by interleukin-1.

1988 • 401 citations

Prostacyclin-mediated activation of peroxisome proliferator-activated receptor δ in colorectal cancer

2000 • 396 citations

Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis.

1999 • 363 citations

Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in F344 rats

1993 • 353 citations

Chemoprevention of intestinal polyposis in the APCDelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor

2000 • 336 citations

Celecoxib prevents tumor growth in vivo without toxicity to normal gut: lack of correlation between in vitro and in vivo models.

2000 • 320 citations

Elevated cyclooxygenase-2 levels in Min mouse adenomas

1996 • 311 citations

Chemoprevention of spontaneous intestinal adenomas in the Apc Min mouse model by the nonsteroidal anti-inflammatory drug piroxicam.

1996 • 294 citations

Thromboxane A2 is a mediator of cyclooxygenase-2-dependent endothelial migration and angiogenesis.

1999 • 292 citations

Expression of cyclooxygenase-2 (COX-2) in human invasive transitional cell carcinoma (TCC) of the urinary bladder.

1999 • 289 citations

NSAIDs inhibit αVβ3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis

2001 • 280 citations

Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2

2000 • 274 citations

Cyclooxygenase-2-dependent arachidonic acid metabolites are essential modulators of the intestinal immune response to dietary antigen

1999 • 272 citations

Malignant Transformation and Antineoplastic Actions of Nonsteroidal Antiinflammatory Drugs (Nsaids) on Cyclooxygenase-Null Embryo Fibroblasts

1999 • 269 citations

Celecoxib inhibits N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced urinary bladder cancers in male B6D2F1 mice and female Fischer-344 rats.

2000 • 263 citations

Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas

1992 • 257 citations

Genetic disruption of PPAR δ decreases the tumorigenicity of human colon cancer cells

2001 • 251 citations

Nuclear localization of prostaglandin E ₂ receptors

1998 • 240 citations

Over-the-counter analgesics and risk of ovarian cancer

1998 • 228 citations

Localization of Cyclooxygenase-2 in Human Sporadic Colorectal Adenomas

2000 • 222 citations

Non-steroidal anti-inflammatory drugs and bladder cancer prevention

2000 • 214 citations

NONSTEROIDAL ANTI-INFLAMMATORY DRUGS, EICOSANOIDS, AND COLORECTAL CANCER PREVENTION

1996 • 212 citations

The expression of p185(HER-2/neu) correlates with the stage of disease and survival in colorectal cancer

1997 • 212 citations

Cyclooxygenase 2 inhibitors: discovery, selectivity and the future

1999 • 211 citations

Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin

2001 • 201 citations

Cyclo‐oxygenase‐2 enhances basic fibroblast growth factor‐induced angiogenesis through induction of vascular endothelial growth factor in rat sponge implants

2000 • 199 citations

Distribution and function of prostanoid receptors: studies from knockout mice

2000 • 193 citations

Nested case–control study of the effects of non-steroidal anti-inflammatory drugs on breast cancer risk and stage

2000 • 186 citations

Prospective Study of Regular Aspirin Use and the Risk of Breast Cancer

1996 • 186 citations

Targeting cyclooxygenase 2 and HER-2/neu pathways inhibits colorectal carcinoma growth

2001 • 181 citations

Cyclooxygenase 2 expression is increased in the stroma of colon carcinomas from IL–10−/− mice

2000 • 180 citations

SHORT COMMUNICATION: Sulindac suppresses tumorigenesis in the Min mouse

1996 • 176 citations

History of aspirin and its mechanism of action.

1990 • 175 citations

Non-steroidal anti-inflammatory drugs and prostate cancer progression

1998 • 174 citations

Meloxicam inhibits the growth of colorectal cancer cells

1998 • 156 citations

Growth stimulation by coexpression of transforming growth factor-alpha and epidermal growth factor-receptor in normal and adenomatous human colon epithelium.

1990 • 149 citations

Reduced expression of cyclooxygenase 2 proteins in hereditary nonpolyposis colorectal cancers relative to sporadic cancers

1999 • 147 citations

Nonsteroidal anti-inflammatory drugs and risk of digestive cancers at sites other than the large bowel.

2000 • 146 citations

Expression of cyclooxygenase-2 mRNA in active inflammatory bowel disease.

1997 • 142 citations

Cyclooxygenase 2 is up-regulated and localized to macrophages in the intestine of Min mice

1999 • 136 citations

High expression of cyclooxygenase-2 in macrophages of human colonic adenoma

1999 • 131 citations

Reduced COX-2 protein in colorectal cancer with defective mismatch repair.

1998 • 121 citations

Inhibitory effect of a prostaglandin E receptor subtype EP1 selective antagonist, ONO-8713, on development of azoxymethane-induced aberrant crypt foci in mice

2000 • 121 citations

Suppressive effects of nimesulide, a selective inhibitor of cyclooxygenase-2, on azoxymethane-induced colon carcinogenesis in mice

1998 • 121 citations

Prostaglandin levels in human colorectal mucosa: effects of sulindac in patients with familial adenomatous polyposis.

1998 • 104 citations

Significant Roles of Inducible Cyclooxygenase (COX)-2 in Angiogenesis in Rat Sponge Implants.

1997 • 103 citations

Prostaglandin J2 and 15-deoxy-delta12,14-prostaglandin J2 induce proliferation of cyclooxygenase-depleted colorectal cancer cells.

1999 • 102 citations

A case-control study of analgesic use and ovarian cancer.

2000 • 101 citations

Differential expression of matrilysin and cyclooxygenase-2 in intestinal and colorectal neoplasms

1999 • 87 citations

Familial adenomatous polyposis

2000 • 85 citations

Inflammation, reproduction, cancer and all that…. The regulation and role of the inducible prostaglandin synthase

1995 • 85 citations

Coordinate regulation of cyclooxygenase-2 and TGF-1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors

1999 • 82 citations

Mucosal synthesis and release of prostaglandin E2 from activated eosinophils and macrophages in ulcerative colitis.

1995 • 54 citations

Chemopreventive Effect of N‐(2‐Cyclohexyloxy‐4‐nitrophenyl)methane Sulfonamide (NS‐398), a Selective Cyclooxygenase‐2 Inhibitor, in Rat Colon Carcinogenesis Induced by Azoxymethane

1999 • 51 citations

A three-dimensional and temporo-spatial model to study invasiveness of cancer cells by heregulin and prostaglandin E2.

2001 • 38 citations

Intestinal Cancer Induced by N-Nitroso Compounds

1988 • 17 citations

Hereditary mixed polyposis syndrome: A zebra or a horse dressed in pinstripes

1997 • 11 citations