Extrathymic Pathways of T-cell Differentiation in the Liver and Other Organs

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

A Syndrome produced by Diverse Nocuous Agents

1936 • 3,733 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

A Class I Antigen, HLA-G, Expressed in Human Trophoblasts

1990 • 1,417 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes.

1986 • 1,106 citations

Correlations and interactions in the production of interleukin-6 (IL- 6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF

1990 • 991 citations

The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice.

1983 • 810 citations

Clonal diseases of large granular lymphocytes [see comments]

1993 • 710 citations

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

1988 • 671 citations

Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells

1985 • 613 citations

The LY‐1B Cell Lineage

1986 • 603 citations

Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation.

1991 • 599 citations

CDlb restricts the response of human CD4−8−T lymphocytes to a microbial antigen

1992 • 577 citations

Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors

1988 • 540 citations

Developmental regulation of T-cell receptor gene expression

1985 • 522 citations

A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment.

1987 • 515 citations

Alternative splicing of HLA-G transcripts yields proteins with primary structures resembling both class I and class II antigens.

1992 • 515 citations

Effect of Hormones on Lymphatic Tissue

1952 • 512 citations

Rheumatoid Factor Secretion from Human Leu-1 ⁺ B Cells

1987 • 442 citations

The mouse gut T lymphocyte, a novel type of T cell. Nature, origin, and traffic in mice in normal and graft-versus-host conditions.

1978 • 422 citations

A novel population of T-cell receptor αβ-bearing thymocytes which predominantly expresses a single Vβ gene family

1987 • 397 citations

The gut‐associated lymphoid system: nature and properties of the large dividing cells

1974 • 391 citations

The hyaluronate receptor is a member of the CD44 (H-CAM) family of cell surface glycoproteins [published erratum appears in J Cell Biol 1991 Feb;112(3):following 513]

1990 • 368 citations

The V beta repertoire of mouse gut homodimeric alpha CD8+ intraepithelial T cell receptor alpha/beta + lymphocytes reveals a major extrathymic pathway of T cell differentiation.

1991 • 345 citations

The Immunobiology of T Cells with Invariant gammadelta Antigen Receptors

1991 • 343 citations

CD44 contributes to T cell activation.

1989 • 324 citations

Characterization of HNK-1+ (Leu-7) human lymphocytes. I. Two distinct phenotypes of human NK cells with different cytotoxic capability.

1982 • 323 citations

Distinct effects of two CD44 isoforms on tumor growth in vivo.

1991 • 315 citations

LFA-3, CD44, and CD45: Physiologic Triggers of Human Monocyte TNF and IL-1 Release

1990 • 300 citations

Functional and biochemical analysis of CD16 antigen on natural killer cells and granulocytes.

1988 • 280 citations

Generation of monoclonal antibodies to a human natural killer clone. Characterization of two natural killer-associated antigens, NKH1A and NKH2, expressed on subsets of large granular lymphocytes.

1985 • 279 citations

An NK1.1+ CD4+8- single-positive thymocyte subpopulation that expresses a highly skewed T-cell antigen receptor V beta family.

1992 • 270 citations

Subsets of CD3⁺ (T cell receptor α/β or γ/δ) and CD3⁻ lymphocytes isolated from normal human gut epithelium display phenotypical features different from their counterparts in peripheral blood

1990 • 269 citations

Thymus-independent development and negative selection of T cells expressing T cell receptor alpha/beta in the intestinal epithelium: evidence for distinct circulation patterns of gut- and thymus-derived T lymphocytes.

1992 • 268 citations

NK1.1⁺ CD4⁺ CD8‐ thymocytes with specific lymphokine secretion

1993 • 265 citations

A population of early fetal thymocytes expressing FcγRIIIII contains precursors of T lymphocytes and natural killer cells

1992 • 264 citations

Development of thymus, parathyroids, and ultimo‐branchial bodies in NMRI and nude mice

1980 • 264 citations

Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor gamma delta.

1991 • 262 citations

A major fraction of human intraepithelial lymphocytes simultaneously expresses the γ/δ T cell receptor, the CD8 accessory molecule and preferentially uses the V_δ1 gene segment

1991 • 261 citations

Cytokine production by CD16^–CD56^bright natural killer cells in the human early pregnancy decidua

1993 • 259 citations

In Vivo Modulation of Cytolytic Activity and Thy-1 Expression In TCR-γδ ⁺ Intraepithelial Lymphocytes

1989 • 258 citations

Monoclonal antibodies specific to native murine T-cell receptor gamma delta: analysis of gamma delta T cells during thymic ontogeny and in peripheral lymphoid organs.

1989 • 257 citations

Induction of a cationic shift in IgG anti-DNA autoantibodies. Role of T helper cells with classical and novel phenotypes in three murine models of lupus nephritis.

1987 • 236 citations

Expression of Murine CD1 on Gastrointestinal Epithelium

1990 • 231 citations

Developmentally regulated expression of T cell receptor beta chain variable domains in immature thymocytes.

1987 • 230 citations

Structure and specificity of T cell receptor gamma/delta on major histocompatibility complex antigen-specific CD3+, CD4-, CD8- T lymphocytes.

1988 • 227 citations

Differential expression of HLA-E, HLA-F, and HLA-G transcripts in human tissue

1990 • 224 citations

Characterization of the interleukin 2 receptor beta chain using three distinct monoclonal antibodies.

1989 • 219 citations

A subset of natural killer cells in peripheral blood displays a mature T cell phenotype.

1986 • 205 citations

The pit cell: Description of a new type of cell occurring in rat liver sinusoids and peripheral blood

1976 • 195 citations

A murine early thymocyte developmental sequence is marked by transient expression of the interleukin 2 receptor.

1989 • 185 citations

Different gamma delta T-cell receptors are expressed on thymocytes at different stages of development.

1989 • 183 citations

Cytotoxic differentiation of mouse gut thymodependent and independent intraepithelial T lymphocytes is induced locally. Correlation between functional assays, presence of perforin and granzyme transcripts, and cytoplasmic granules.

1991 • 183 citations

Interleukin 2: A Class of T Cell Growth Factors

1980 • 178 citations

Novel function for intestinal intraepithelial lymphocytes. Murine CD3+, gamma/delta TCR+ T cells produce IFN-gamma and IL-5.

1991 • 175 citations

The effect of antigen deprivation on thymus-dependent and thymus-independent lymphocytes in the small intestine of the mouse.

1972 • 174 citations

Liver is a possible site for the proliferation of abnormal CD3+4-8- double-negative lymphocytes in autoimmune MRL-lpr/lpr mice.

1990 • 173 citations

Differentiation potential of subsets of CD4−8− thymocytes

1987 • 169 citations

Details of an isolation method for hepatic lymphocytes in mice

1992 • 169 citations

Recognition of a self major histocompatibility complex TL region product by gamma delta T-cell receptors.

1989 • 168 citations

Cytokine production by mature and immature CD4-CD8- T cells. Alpha beta-T cell receptor+ CD4-CD8- T cells produce IL-4.

1992 • 167 citations

Lectin-dependent and anti-CD3 induced cytotoxicity are preferentially mediated by peripheral blood cytotoxic T lymphocytes expressing Leu-7 antigen.

1986 • 164 citations

Expression of the thymus leukemia antigen in mouse intestinal epithelium.

1990 • 161 citations

Estrogen administration activates extrathymic T cell differentiation in the liver.

1992 • 153 citations

An unusual lineage of alpha/beta T cells that contains autoreactive cells.

1991 • 152 citations

Isolation and flow cytometric analysis of the free lymphomyeloid cells present in murine liver

1990 • 148 citations

The appearance of T cells bearing self-reactive T cell receptor in the livers of mice injected with bacteria.

1991 • 145 citations

Analysis of HLA-G mRNA in human placental and extraplacental membrane cells by in situ hybridization.

1991 • 144 citations

Differentiation and functional maturation of bone marrow-derived intestinal epithelial T cells expressing membrane T cell receptor in athymic radiation chimeras.

1990 • 144 citations

CD44 can be activated to function as an hyaluronic acid receptor in normal murine T cells

1992 • 144 citations

The thymus has two functionally distinct populations of immature αβ+ T cells: One population is deleted by ligation of αβTCR

1989 • 140 citations

Proliferative responses of human intraepithelial lymphocytes to various T-cell stimuli

1989 • 138 citations

Influence of collection and separation of blood samples on plasma IL-1, IL-6 and TNF-α concentrations

1992 • 136 citations

Characterization of human granular lymphocyte subpopulations expressing HNK‐1 (Leu‐7) and Leu‐11 antigens in the blood and lymphoid tissues from fetuses, neonates and adults

1984 • 134 citations

Extrathymic development of V alpha 14-positive T cells.

1993 • 132 citations

Age-dependent increase of extrathymic T cells in the liver and their appearance in the periphery of older mice.

1992 • 130 citations

The fate of CD4-8- T cell receptor-alpha beta+ thymocytes.

1991 • 129 citations

Unusual alpha beta-T cells expanded in autoimmune lpr mice are probably a counterpart of normal T cells in the liver.

1991 • 124 citations

Characterization of gamma delta T lymphocytes at the maternal-fetal interface.

1992 • 122 citations

Phenotype of intraepithelial lymphocytes in euthymic and athymic mice: Implications for differentiation of cells bearing a CD3‐associated γδ T cell receptor

1990 • 116 citations

Kinetic analysis of cytokine gene expression in the livers of naive and immune mice infected with Listeria monocytogenes. The immediate early phase in innate resistance and acquired immunity.

1992 • 113 citations

Regulation of cytokine production in the human thymus: epidermal growth factor and transforming growth factor alpha regulate mRNA levels of interleukin 1 alpha (IL-1 alpha), IL-1 beta, and IL-6 in human thymic epithelial cells at a post-transcriptional level.

1991 • 109 citations

Phenotype, ontogeny, and repertoire of CD4-CD8- T cell receptor alpha beta + thymocytes. Variable influence of self-antigens on T cell receptor V beta usage.

1991 • 107 citations

Ontogeny and development of extrathymic T cells in mouse liver.

1992 • 100 citations

Spontaneous development of organ-specific autoimmune lesions in aged C57BL/6 mice.

1989 • 95 citations

Thymic Requirement for Clonal Deletion During T Cell Development

1989 • 95 citations

The glycolipid asialo GM1 as a new differentiation antigen of fetal thymocytes.

1980 • 90 citations

T-cell function and specificity in athymic mice

1983 • 90 citations

CD4⁺ CD8⁺ murine intestinal intraepithelial Iymphocytes

1990 • 90 citations

Expression of class I HLA genes by trophoblast cells. Analysis by in situ hybridization.

1988 • 86 citations

Distribution and morphological characteristics of the pit cells in the liver of the rat

1983 • 85 citations

Age-related variation in the proportion and activity of murine liver natural killer cells and their cytotoxicity against regenerating hepatocytes.

1988 • 85 citations

Studies of CD4- CD8- alpha beta bone marrow T cells with suppressor activity.

1992 • 82 citations

T cell antigen receptor expression in athymic (nu/nu) mice. Evidence for an oligoclonal beta chain repertoire.

1987 • 81 citations

Interleukin 2 abrogates the nonresponsive state of T cells expressing a forbidden T cell receptor repertoire and induces autoimmune disease in neonatally thymectomized mice.

1991 • 81 citations

The HLA-E gene encodes two differentially regulated transcripts and a cell surface protein.

1992 • 81 citations

CD4+ T cell lines with selective patterns of autoreactivity as well as CD4- CD8- T helper cell lines augment the production of idiotypes shared by pathogenic anti-DNA autoantibodies in the NZB x SWR model of lupus nephritis.

1988 • 78 citations

Evidence for the expression of non-HLA-A,-B,-C class I genes in the human fetal liver.

1992 • 77 citations

Failure of T Cell Receptor V _β Negative Selection in an Athymic Environment

1989 • 76 citations

Age‐associated increase in number of CD4⁺CD8⁺ intestinal intraepithelial lymphocytes in rats

1992 • 75 citations

Identification of activated T cell receptor gamma delta lymphocytes in the liver of tumor-bearing hosts.

1990 • 75 citations

Predominant appearance of γ/δ T lymphocytes in the liver of mice after birth

1991 • 72 citations

Similarities and Differences between Extrathymic T Cells Residing in Mouse Liver and Intestine

1994 • 71 citations

Developmental potential of CD4-8- thymocytes. Peripheral progeny include mature CD4-8- T cells bearing alpha beta T cell receptor.

1989 • 71 citations

Intra-epithelial lymphocytes: interferon-gamma production and suppressor/cytotoxic activities

1990 • 68 citations

Phenotypic heterogeneity of intraepithelial T lymphocytes from mouse small intestine.

1991 • 67 citations

Expansion of the population of double negative CD4-8- T alpha beta-cells in the liver is a common feature of autoimmune mice.

1991 • 67 citations

Evidence for extrathymic development of TNK cells. NK1+ CD3+ cells responsible for acute marrow graft rejection are present in thymus-deficient mice.

1992 • 64 citations

Molecular cloning of orangutan and gibbon MHC class I cDNA. The HLA-A and -B loci diverged over 30 million years ago.

1992 • 63 citations

Unusual phenotype of intestinal intraepithelial lymphocytes in the rat: predominance of T cell receptor α/β⁺/CD2⁻ cells and high expression of the RT6 alloantigen

1991 • 58 citations

In vivo T-cell activation by staphylococcal enterotoxin B prevents outgrowth of a malignant tumor.

1991 • 55 citations

Failure of T cell receptor Vβ negative selection in murine intestinal intra-epithelial lymphocytes

1991 • 55 citations

Augmentation of mouse liver-associated natural killer activity by biologic response modifiers occurs largely via rapid recruitment of large granular lymphocytes from the bone marrow.

1989 • 55 citations

Extrathymic Pathways of T‐Cell Differentiation: A Primitive and Fundamental Immune System

1993 • 54 citations

Evidence for CD8-independent T cell maturation in transgenic mice.

1990 • 53 citations

Ageing compromises gastrointestinal mucosal immune response in the rhesus monkey.

1992 • 53 citations

Reciprocal T cell responses in the liver and thymus of mice injected with syngeneic tumor cells

1991 • 53 citations

Antigen-specific and polyclonal CD4+ lamina propria T-cell lines: phenotypic and functional characterization.

1992 • 51 citations

T cell antigen receptor expression by subsets of Ly-2-L3T4- (CD8-CD4-) thymocytes.

1988 • 51 citations

The role of Kupffer cells in glucan-induced granuloma formation in the liver of mice depleted of blood monocytes by administration of strontium-89.

1991 • 51 citations

Thymic involution and thymocyte phenotypic alterations induced by murine mammary adenocarcinomas.

1989 • 50 citations

Intrathymic selection of murine TCRαβ⁺CD4⁻CD8⁻ thymocytes

1990 • 50 citations

Congenitally athymic nude (nu/nu) mice have Thy-1-bearing immunocompetent helper T cells in their peritoneal cavity.

1980 • 49 citations

Functional α and β T cell chain receptor messages can be detected in old but not in young athymic mice

1987 • 49 citations

Origin, differentiation, and repertoire selection of CD3+CD4-CD8- thymocytes bearing either alpha beta or gamma delta T cell receptors.

1993 • 48 citations

Selective activation of extrathymic T cells in the liver by glycyrrhizin

1992 • 47 citations

Production of interleukin 6 from human liver cell lines: production of interleukin 6 is not concurrent with the production of alpha-fetoprotein.

1990 • 45 citations

Lymphokine-activated killer cell activity of CD4-CD8- TCR alpha beta + thymocytes.

1993 • 43 citations

Glucocorticoid Independence of Acute Thymic Involution Induced by Lymphotoxin and Estrogen

1994 • 43 citations

Distinctive selection mechanisms govern the T cell receptor repertoire of peripheral CD4-CD8- alpha/beta T cells.

1992 • 43 citations

Characterization of V_β‐bearing cells in athymic (nu/nu) mice suggests an extrathymic pathway for T cell differentiation

1990 • 41 citations

CD4⁻CD8⁻ thymocytes that express the T cell receptor may have previously expressed CD8

1990 • 41 citations

<b>EXTRATHYMIC DIFFERENTIATION OF T LYMPHOCYTES AND ITS BIOLOGICAL </b><b>FUNCTION </b>

1992 • 40 citations

Fetal skin: a site of dendritic epidermal T cell development.

1992 • 39 citations

The thymus leukemia antigen binds human and mouse CD8.

1991 • 39 citations

Characterization of T cells infiltrating the heart in rats with experimental autoimmune myocarditis. Their similarity to extrathymic T cells in mice and the site of proliferation.

1993 • 39 citations

Characterization of Intermediate TCR Cells in the Liver of Mice with Respect to Their Unique IL-2R Expression

1993 • 38 citations

Presence of intestinal intraepithelial lymphocytes in mice with severe combined immunodeficiency disease

1990 • 37 citations

Development of autoreactive L3T4⁺ T cells from double‐negative (L3T4⁻/Ly‐2⁻) Thy‐1⁺ spleen cells of normal mice

1988 • 37 citations

Molecular characterization of T-cell antigen receptor expression by subsets of CD4- CD8- murine thymocytes.

1988 • 37 citations

CD4-CD8- T cell receptor alpha beta T cells: generation of an in vitro major histocompatibility complex class I specific cytotoxic T lymphocyte response and allogeneic tumor rejection.

1991 • 33 citations

Detailed characterization of gamma delta T cells within the organs in mice: classification into three groups.

1993 • 33 citations

Autoimmunity and aging.

1985 • 32 citations

Liver-associated large granular lymphocytes: Morphological and functional aspects.

1989 • 31 citations

Activation of extrathymic T cells in the liver during liver regeneration following partial hepatectomy.

1993 • 31 citations

Fc gamma RIII expressed on cultured monocytes is a N-glycosylated transmembrane protein distinct from Fc gamma RIII expressed on natural killer cells.

1990 • 31 citations

Regulation of Interleukin‐6 Production in Human Fetal Kupffer Cells

1991 • 31 citations

Rat thymic epithelial cells in culture constitutively secrete IL-1 and IL-6

1991 • 28 citations

Phenotypic and Functional Characteristics of ‘T-Like’ Cells in Nude Mice

1984 • 28 citations

Human T cell responses to IL-1 and IL-6 are dependent on signals mediated through CD2.

1991 • 27 citations

Radioresistance of Intermediate TCR Cells and Their Localization in the Body of Mice Revealed by Irradiation

1993 • 26 citations

Activation of extrathymic T cells in the liver and reciprocal inactivation of intrathymic T cells by bacterial stimulation

1992 • 25 citations

The Liver and the Hematolymphoid System: I. The Regulation of Nylon-Passed Spleen Cell Proliferation by Active Factors Released From Syngeneic Nonparenchymal Liver Cells

1991 • 21 citations

Clonal deletion and autoreactivity in extrathymic CD4-CD8-(double negative) T cell receptor-alpha/beta T cells.

1991 • 20 citations

Lymphotoxin activates hepatic T cells and simultaneously induces profound thymic atrophy.

1992 • 18 citations

Predominant Activation of Extrathymic T Cells during Melanoma Development of Metallothionein/ret Transgenic Mice

1994 • 18 citations

T Cell receptor expression by T cells that mature extrathymically in nude mice

1991 • 18 citations

A gamma/delta cell receptor heterodimer induces the expression of CD4 and CD8 in thymocytes.

1991 • 17 citations

In vivo and in vitro repertoire of CD3⁺CD4−CD8–thymocytes

1990 • 17 citations

Developmental and tissue-specific expression of the Q5 k gene

1991 • 16 citations

Abnormal thymic development, impaired immune function and gamma delta T cell lymphomas in a TL transgenic mouse strain.

1991 • 16 citations

<b>ACTIVATION OF EXTRATHYMIC T CELLS IN THE LIVER OF MICE BEARING SYNGENEIC </b><b>TUMORS </b>

1993 • 16 citations

Induction of Specific Tolerance by Hepatic Double-Negative CD4-8-αβ T Cells of Mice Immunized with Allogeneic Cells via the Portal Vein in Vitro

1993 • 14 citations

Age-Associated Increase of CD5⁺B Cells in the Liver of Autoimmune (NZB × NZW) F₁Mice

1993 • 14 citations

Relative resistance of intermediate TCR cells to anti-CD3 mAb in mice in vivo and their partial functional characterization

1992 • 13 citations

Characterization of constitutive and strain-dependent subsets of CD45RA⁺ cells in the thymus

1992 • 9 citations

<b>GENERALIZED EXPANSION OF EXTRATHYMIC T CELLS IN VARIOUS IMMUNE ORGANS OF TL-TRANSGENIC </b><b>MICE </b>

1993 • 7 citations

Characterization of αβ+ CD4− CD8− CTL lines isolated from mixed lymphocyte cultures of adult mouse spleen cells

1992 • 5 citations

<b>CD<sup>5+</sup> B CELLS IN THE THYMUS OF PATIENTS WITH MYASTHENIA GRAVIS </b>

1993 • 5 citations

Multiplicity of Sites for Extrathymic T-cell Differentiation

1993 • 1 citations