Vβ Gene Repertoire in the Aging Mouse: A Developmental Perspective

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

Murine Models of Systemic Lupus Erythematosus

1985 • 1,572 citations

MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation

1994 • 1,448 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

1991 • 876 citations

The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen.

1992 • 839 citations

Negative selection of lymphocytes

1994 • 810 citations

Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy".

1994 • 788 citations

Superantigens: Mechanism of T-Cell Stimulation and Role in Immune Responses

1991 • 783 citations

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

1984 • 644 citations

Positive selection of lymphocytes

1994 • 563 citations

Expression of Two T Cell Receptor α Chains: Dual Receptor T Cells

1993 • 527 citations

Molecular and Cellular Events of T Cell Development

1989 • 466 citations

The thymic microenvironment

1993 • 459 citations

Structure, Organization and Polymorphism of Murine and Human T‐Cell Receptor a and β Chain Gene Families

1988 • 448 citations

Helper T‐Cell Subsets: Phenotype, Function and the Role of Lymphokines in Regulating their Development

1991 • 423 citations

Programmed cell death, apoptosis and killer genes

1993 • 396 citations

Lymphoid Development in Mice Congenitally Lacking T Cell Receptor αβ-Expressing Cells

1992 • 371 citations

Aging and Immune Function

1991 • 361 citations

Patterns of cytokine gene expression by CD4+ T cells from young and old mice.

1993 • 357 citations

The toxicity of staphylococcal enterotoxin B in mice is mediated by T cells.

1990 • 347 citations

The Immunobiology of T Cells with Invariant gammadelta Antigen Receptors

1991 • 343 citations

Switch of CD8 T Cells to Noncytolytic CD8 ^- CD4 ^- Cells that Make T _H 2 Cytokines and Help B Cells

1993 • 343 citations

A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein

1993 • 333 citations

The Cellular and Subcellular Bases of Immunosenescence

1989 • 326 citations

Clonal predominance of T cell receptors within the CD8+ CD45RO+ subset in normal human subjects.

1993 • 298 citations

Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene.

1993 • 287 citations

T and B memory cells

1994 • 285 citations

Regulation of TCR α and β gene allelic exclusion during T-cell development

1992 • 284 citations

Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice.

1990 • 264 citations

Dihydrotestosterone exerts a depressive influence on the production of interleukin-4 (IL-4), IL-5, and gamma-interferon, but not IL-2 by activated murine T cells

1991 • 246 citations

The defect in Fas mRNA expression in MRL/lpr mice is associated with insertion of the retrotransposon, ETn.

1993 • 241 citations

Precursors of T cell growth factor producing cells in the thymus: ontogeny, frequency, and quantitative recovery in a subpopulation of phenotypically mature thymocytes defined by monoclonal antibody GK-1.5.

1983 • 237 citations

Mls — a retrovirus exploits the immune system

1991 • 233 citations

Unexpected expansions of CD8-bearing cells in old mice.

1993 • 228 citations

Memory B and T Cells

1991 • 183 citations

The age-associated increase in IFN-gamma synthesis by mouse CD8+ T cells correlates with shifts in the frequencies of cell subsets defined by membrane CD44, CD45RB, 3G11, and MEL-14 expression.

1993 • 168 citations

Immunological Memory

1993 • 166 citations

Cell-mediated immunity in aged mice: an underlying lesion in IL 2 synthesis.

1982 • 159 citations

Positive and negative selection of T cells in T-cellreceptor transgenic mice expressing a bcl-2 transgene.

1994 • 147 citations

Deletion of potentially self-reactive T cell receptor specificities in L3T4-, Lyt-2- T cells of lpr mice.

1988 • 142 citations

Expression of two alpha chains on the surface of T cells in T cell receptor transgenic mice.

1993 • 136 citations

Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice

1992 • 130 citations

Age-dependent increase of extrathymic T cells in the liver and their appearance in the periphery of older mice.

1992 • 130 citations

Tolerance-related V beta clonal deletions in normal CD4-8-, TCR-alpha/beta + and abnormal lpr and gld cell populations.

1989 • 127 citations

Developmental switches in the immune system

1994 • 126 citations

Junctional sequences of fetal T cell receptor beta chains have few N regions.

1991 • 117 citations

A special repertoire of alpha:beta T cells in neonatal mice.

1991 • 108 citations

Postnatal disappearance of self-reactive (V beta 6+) cells from the thymus of Mlsa mice. Implications for T cell development and autoimmunity.

1989 • 108 citations

Phenotype, ontogeny, and repertoire of CD4-CD8- T cell receptor alpha beta + thymocytes. Variable influence of self-antigens on T cell receptor V beta usage.

1991 • 107 citations

Cell proliferation and differentiation in the fetal and early postnatal mouse thymus.

1989 • 104 citations

Accelerated programmed cell death of MRL-lpr/lpr T lymphocytes.

1992 • 71 citations

The Molecular Pathology of Autoimmune Diseases

1993 • 66 citations

Relative V beta transcript levels in thymus and peripheral lymphoid tissues from various mouse strains. Inverse correlation of I-E and Mls expression with relative abundance of several V beta transcripts in peripheral lymphoid tissues.

1989 • 65 citations

Selective decreases in T cell receptor V beta expression. Decreased expression of specific V beta families is associated with expression of multiple MHC and non-MHC gene products.

1989 • 63 citations

Activation of Polyphosphoinositide Hydrolysis in T Cells by H-2 Alloantigen But Not MLS Determinants

1990 • 59 citations

Thymocyte subpopulations during early fetal development in the BALB/c mouse.

1988 • 53 citations

Effects of aging on cell cooperation and lymphocyte responsiveness to cytokines.

1983 • 51 citations

T-cell receptor alpha-chain variable-region haplotypes of normal and autoimmune laboratory mouse strains.

1988 • 50 citations

T‐Cell Receptor Vβ Repertoire Expression in Murine Models of SLE

1990 • 48 citations

Diversity, Development, Ligands, and Probable Functions of T Cells

1989 • 47 citations

Conventional antigen and superantigen may be coupled to distinct and cooperative T-cell activation pathways.

1991 • 46 citations

V beta gene repertoires in aging mice.

1992 • 46 citations

Thymic selection defines multiple T cell receptor V beta ‘repertoire phenotypes’ at the CD4/CD8 subset level.

1990 • 43 citations

T cell tolerance to self antigens in New Zealand hybrid mice with lupus-like disease.

1989 • 39 citations

Aging and lymphokine production by t cell subsets

1993 • 29 citations

Why is clonal deletion of neonatal thymocytes defective?

1992 • 19 citations

Age-related changes in immune reactivity: the influence of intrinsic defects and of a changed composition of the CD4+ T cell compartment.

1992 • 13 citations