The cellular response to unfolded proteins: intercompartmental signaling

Protein folding in the cell

1992 • 4,138 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

1988 • 1,292 citations

The biology of heat shock proteins and molecular chaperones

1994 • 1,203 citations

Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

1993 • 1,197 citations

Immunoglobulin heavy chain binding protein

1983 • 849 citations

A transmembrane protein with a cdc2+CDC28-related kinase activity is required for signaling from the ER to the nucleus

1993 • 814 citations

KAR2, a karyogamy gene, is the yeast homolog of the mammalian BiP/GRP78 gene

1989 • 684 citations

Is hsp70 the cellular thermometer?

1991 • 586 citations

Production of abnormal proteins in E. coli stimulates transcription of ion and other heat shock genes

1985 • 521 citations

REGULATION OF THE HEAT-SHOCK RESPONSE IN BACTERIA

1993 • 473 citations

Protein disulfide isomerase: Multiple roles in the modification of nascent secretory proteins

1989 • 466 citations

Mammalian stress response: induction of the glucose-regulated protein family

1992 • 452 citations

S. cerevisiae encodes an essential protein homologous in sequence and function to mammalian BiP

1989 • 421 citations

Isolation of the gene encoding the S. cerevisiae heat shock transcription factor

1988 • 417 citations

The activity of sigma E, an Escherichia coli heat-inducible sigma-factor, is modulated by expression of outer membrane proteins.

1993 • 400 citations

A 22 bp cis-acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteins.

1992 • 375 citations

Glucose depletion accounts for the induction of two transformation-sensitive membrane proteinsin Rous sarcoma virus-transformed chick embryo fibroblasts.

1977 • 371 citations

Folding, interaction with GRP78-BiP, assembly, and transport of the human immunodeficiency virus type 1 envelope protein

1991 • 333 citations

The Promoter Region of the Yeast KAR2 (BiP) Gene Contains a Regulatory Domain that Responds to the Presence of Unfolded Proteins in the Endoplasmic Reticulum

1993 • 328 citations

ERp99, an abundant, conserved glycoprotein of the endoplasmic reticulum, is homologous to the 90-kDa heat shock protein (hsp90) and the 94-kDa glucose regulated protein (GRP94).

1987 • 294 citations

Stress proteins in biology and medicine

1990 • 273 citations

Yeast heat shock factor contains separable transient and sustained response transcriptional activators

1990 • 269 citations

ERp72, an abundant luminal endoplasmic reticulum protein, contains three copies of the active site sequences of protein disulfide isomerase.

1990 • 254 citations

The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum.

1993 • 246 citations

Endoplasmic reticulum contains a common, abundant calcium-binding glycoprotein, endoplasmin

1986 • 236 citations

Transactivation of the grp78 promoter by Ca2+ depletion. A comparative analysis with A23187 and the endoplasmic reticulum Ca(2+)-ATPase inhibitor thapsigargin

1993 • 228 citations

Regulating the retention of T-cell receptor alpha chain variants within the endoplasmic reticulum: Ca(2+)-dependent association with BiP.

1991 • 210 citations

The essential function of yeast protein disulfide isomerase does not reside in its isomerase activity

1993 • 201 citations

IRE1 encodes a putative protein kinase containing a membrane‐spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiae

1992 • 192 citations

The stress response in Chinese hamster ovary cells. Regulation of ERp72 and protein disulfide isomerase expression and secretion.

1990 • 186 citations

Induction of a heat shock-like response by unfolded protein in Escherichia coli: dependence on protein level not protein degradation.

1989 • 180 citations

The ubiquitous glucose transporter GLUT-1 belongs to the glucose-regulated protein family of stress-inducible proteins.

1991 • 172 citations

ERD1, a yeast gene required for the retention of luminal endoplasmic reticulum proteins, affects glycoprotein processing in the Golgi apparatus.

1990 • 160 citations

The unfolded-protein-response pathway in yeast

1994 • 154 citations

Transactivation of the grp78 promoter by malfolded proteins, glycosylation block, and calcium ionophore is mediated through a proximal region containing a CCAAT motif which interacts with CTF/NF-I.

1991 • 151 citations

The yeast EUG1 gene encodes an endoplasmic reticulum protein that is functionally related to protein disulfide isomerase.

1992 • 150 citations

Rat gene encoding the 78-kDa glucose-regulated protein GRP78: its regulatory sequences and the effect of protein glycosylation on its expression.

1987 • 144 citations

9 Properties of the Heat Shock Proteins of Escherichia coli and the Autoregulation of the Heat Shock Response

1994 • 137 citations

Glycosylation site binding protein and protein disulfide isomerase are identical and essential for cell viability in yeast.

1991 • 137 citations

Transcriptional regulation of an hsp70 heat shock gene in the yeast Saccharomyces cerevisiae.

1987 • 128 citations

The accumulation of three specific proteins related to glucose‐regulated proteins in a temperature‐sensitive hamster mutant cell line K12

1981 • 125 citations

Protein disulfide isomerase is essential for viability in Saccharomyces cerevisiae

1991 • 123 citations

BIP associates with newly synthesized subunits of the mouse muscle nicotinic receptor.

1991 • 108 citations

8 The Function and Regulation of Heat Shock Proteins in Escherichia coli

1990 • 103 citations

Establishment of a chinese hamster ovary cell line that expresses grp78 antisense transcripts and suppresses A23187 induction of both GRP78 and GRP94

1992 • 95 citations

Enhanced synthesis of stress proteins caused by hypoxia and relation to altered cell growth and metabolism

1990 • 91 citations

The FKB2 gene of Saccharomyces cerevisiae, encoding the immunosuppressant-binding protein FKBP-13, is regulated in response to accumulation of unfolded proteins in the endoplasmic reticulum.

1993 • 90 citations

Accumulation of secretory protein precursors in Escherichia coli induces the heat shock response

1993 • 83 citations

Increased cytotoxicity of chronic hypoxic cells by molecular inhibition of GRP78 induction

1994 • 80 citations

Competitive Inhibition of a Set of Endoplasmic Reticulum Protein Genes (GRP78, GRP94, and ERp72) Retards Cell Growth and Lowers Viability after Ionophore Treatment

1991 • 75 citations

Purification and characterization of BiP/Kar2 protein from Saccharomyces cerevisiae.

1992 • 56 citations

<scp>III</scp>. Yeast sequencing reports. Determination of the sequence of the yeast YCL313 gene localized on chromosome III. Homology with the protein disulfide isomerase (PDI gene product) of other organisms

1991 • 54 citations

Competitive inhibition of a set of endoplasmic reticulum protein genes (GRP78, GRP94, and ERp72) retards cell growth and lowers viability after ionophore treatment.

1991 • 53 citations

A mutation in the ectodomain of herpes simplex virus 1 glycoprotein B causes defective processing and retention in the endoplasmic reticulum

1991 • 52 citations

Structure and assembly of the endoplasmic reticulum: Biosynthesis and intracellular sorting of ERp61, ERp59, and ERp49, three protein components of murine endoplasmic reticulum

1986 • 48 citations

The Saccharomyces cerevisiae TRG1 gene is essential for growth and encodes a lumenal endoplasmic reticulum glycoprotein involved in the maturation of vacuolar carboxypeptidase.

1991 • 43 citations

A Binding Site for the Cyclic Adenosine 3′,5′-Monophosphate-Response Element-Binding Protein as a Regulatory Element in the grp78 Promoter

1991 • 42 citations

Coordinated induction of two unrelated glucose-regulated protein genes by a calcium ionophore: Human BiPGRP78 and GAPDH

1990 • 35 citations

5 Structure, Function, and Regulation of the Endoplasmic Reticulum Chaperone, BiP

1994 • 21 citations