Distinct forms of human CDC2 identified by novel monoclonal antibodies

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

Cyclin A is required at two points in the human cell cycle.

1992 • 1,380 citations

Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

1989 • 1,237 citations

Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

1987 • 1,153 citations

cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2

1991 • 870 citations

Activation of cdc2 protein kinase during mitosis in human cells: Cell cycle-dependent phosphorylation and subunit rearrangement

1988 • 786 citations

Dominoes and Clocks: the Union of Two Views of the Cell Cycle

1989 • 750 citations

The cdc25 protein contains an intrinsic phosphatase activity

1991 • 595 citations

Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein

1991 • 579 citations

Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies.

1991 • 512 citations

The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system

1991 • 504 citations

Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase

1991 • 475 citations

Purification of MPF from starfish: Identification as the H1 histone kinase p34cdc2 and a possible mechanism for its periodic activation

1989 • 366 citations

Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation

1990 • 364 citations

Identification of p34 and p13, human homologs of the cell cycle regulators of fission yeast encoded by cdc2+ and suc1+

1987 • 341 citations

cdc2 phosphorylation is required for its interaction with cyclin.

1991 • 338 citations

A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1.

1991 • 265 citations

A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells

1989 • 262 citations

Cloning by differential screening of a Xenopus cDNA coding for a protein highly homologous to cdc2.

1991 • 225 citations

Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe.

1990 • 181 citations

G1-specific cyclins: in search of an S-phase-promoting factor

1991 • 181 citations

Activation of M-phase-specific histone H1 kinase by modification of the phosphorylation of its p34cdc2 and cyclin components.

1990 • 150 citations

Cyclin-dependent kinases: a new cell cycle motif?

1991 • 148 citations

Activation of human CDC2 protein as a histone H1 kinase is associated with complex formation with the p62 subunit.

1989 • 148 citations

Recognition of the adenovirus type 2 origin of DNA replication by the virally encoded DNA polymerase and preterminal proteins.

1992 • 93 citations

Mutations at sites involved in Suc1 binding inactivate Cdc2.

1991 • 63 citations

Cell cycle control in eukaryotes

1989 • 17 citations