The Association of Atopy with a Gain-of-Function Mutation in the α Subunit of the Interleukin-4 Receptor

Diagnostic Features of Atopic Dermatitis

1980 • 4,910 citations

Exposure to House-Dust Mite Allergen (Der pI) and the Development of Asthma in Childhood

1990 • 1,677 citations

Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC

1993 • 1,273 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

Linkage Analysis of IL4 and Other Chromosome 5q31.1 Markers and Total Serum Immunoglobulin E Concentrations

1994 • 1,025 citations

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

An Interleukin-4-Induced Transcription Factor: IL-4 Stat

1994 • 856 citations

Genetic Susceptibility to Asthma — Bronchial Hyperresponsiveness Coinherited with a Major Gene for Atopy

1995 • 774 citations

Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4

1993 • 734 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-4 Receptor

1993 • 593 citations

Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I

1995 • 571 citations

House dust mite allergens. A major risk factor for childhood asthma in Australia.

1996 • 496 citations

Human recombinant interleukin 4 induces Fc epsilon receptors (CD23) on normal human B lymphocytes.

1987 • 449 citations

Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily.

1990 • 430 citations

IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice

1990 • 410 citations

Association between atopy and variants of the β subunit of the high–affinity immunoglobulin E receptor

1994 • 406 citations

Truncated erythropoietin receptor causes dominantly inherited benign human erythrocytosis.

1993 • 404 citations

Evidence for a Locus Regulating Total Serum IgE Levels Mapping to Chromosome 5

1994 • 395 citations

Direct Regulation of ZAP-70 by SHP-1 in T Cell Antigen Receptor Signaling

1996 • 390 citations

Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences.

1992 • 367 citations

Hematopoietic Cell Phosphatase Associates with the Interleukin-3 (IL-3) Receptor β Chain and Down-Regulates IL-3-Induced Tyrosine Phosphorylation and Mitogenesis

1993 • 340 citations

Antibody Class Switching

1996 • 327 citations

cDNA Cloning and Characterization of the Human Interleukin 13 Receptor α Chain

1996 • 285 citations

HLA-Dw2: a genetic marker for human immune response to short ragweed pollen allergen Ra5. I. Response resulting primarily from natural antigenic exposure.

1982 • 236 citations

Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis.

1993 • 204 citations

Regulation of Colony-Stimulating Factor 1 Receptor Signaling by the SH2 Domain-Containing Tyrosine Phosphatase SHPTP1

1996 • 199 citations

Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1

1996 • 167 citations

Primary familial polycythemia: a frameshift mutation in the erythropoietin receptor gene and increased sensitivity of erythroid progenitors to erythropoietin

1995 • 161 citations

Bronchial hyperresponsiveness in two populations of Australian schoolchildren. III. Effect of exposure to environmental allergens

1987 • 161 citations

Osteoporosis induced in mice by overproduction of interleukin 4.

1993 • 159 citations

HLA‐DR and HLA‐DP genotypes and immunoglobulin E responses to common major allergens

1994 • 158 citations

Growth and Gene Expression Are Predominantly Controlled by Distinct Regions of the Human IL-4 Receptor

1996 • 158 citations

Signaling via IL-2 and IL-4 in JAK3-Deficient Severe Combined Immunodeficiency Lymphocytes: JAK3-Dependent and Independent Pathways

1996 • 129 citations

Association of the Interferon-dependent Tyrosine Kinase Tyk-2 with the Hematopoietic Cell Phosphatase

1995 • 121 citations

Molecular cloning of a cDNA encoding the human interleukin 4 receptor

1990 • 119 citations

Distribution of allergy in a population sample residing in Tucson, Arizona.

1989 • 89 citations

Serum total immunoglobulin E levels in Canadian adults

1984 • 87 citations

Regulation of immunoglobulin (Ig)E synthesis in the hyper-IgE syndrome.

1990 • 78 citations

Interleukin-4 (IL-4) Induces Phosphatidylinositol 3-Kinase (p85) Dephosphorylation

1997 • 56 citations

House dust mite sensitivity: interaction of genetics and allergen dosage

1992 • 43 citations

Hyperimmunoglobulin E syndrome

2011 • 35 citations

Hyperimmunoglobulinemia E syndrome: association with osteoporosis and recurrent fractures.

1985 • 28 citations

Regulation of IgE and IgG4 synthesis in patients with hyper IgE syndrome.

1990 • 27 citations

Genetics of allergy.

1993 • 24 citations

Regulation of Human IgE Synthesis

1996 • 19 citations

Over-expression of protein tyrosine phosphatase 1 (PTP1) alters IL-3-dependent growth and tyrosine phosphorylation.

1996 • 12 citations